A role for maternal IgG in protecting infants from allergen-specific IgE sensitization
After birth, transfer is through the gut, which is less efficient. [...]the vast majority of maternally transmitted IgG is acquired before birth. A second finding was that children with IgE sensitization against a particular allergen also had significantly greater allergen-specific IgG levels to tha...
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Veröffentlicht in: | Journal of allergy and clinical immunology 2019-08, Vol.144 (2), p.410-412 |
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description | After birth, transfer is through the gut, which is less efficient. [...]the vast majority of maternally transmitted IgG is acquired before birth. A second finding was that children with IgE sensitization against a particular allergen also had significantly greater allergen-specific IgG levels to that same allergen. [...]endogenous production by the child of IgG against the allergen did not provide the protection given by maternal allergen-specific IgG. [...]the role of maternal IgG in manipulating the IgE or IgG response in patients with nonallergic conditions remains an open question. |
doi_str_mv | 10.1016/j.jaci.2019.05.039 |
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[...]the role of maternal IgG in manipulating the IgE or IgG response in patients with nonallergic conditions remains an open question.</description><subject>Age</subject><subject>Allergens</subject><subject>allergic sensitization</subject><subject>Allergies</subject><subject>Antigens</subject><subject>Atopy</subject><subject>Birth</subject><subject>Breastfeeding & lactation</subject><subject>Child</subject><subject>Children & youth</subject><subject>Disease</subject><subject>Disease prevention</subject><subject>fetal immune development</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immune System Diseases</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulins</subject><subject>Infant</subject><subject>Infants</subject><subject>maternal IgG</subject><subject>Microbiota</subject><subject>Mothers</subject><subject>ontogeny of the immune system</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpSTZp_kAPRdBLLnYlWbIsyCWEfEEgl7ZXIcujRcaWtpK3kPz6yGySQw85DQPP-zLzIPSNkpoS2v4c69FYXzNCVU1ETRr1CW0oUbJqOyY-ow0hilat5OoYneQ8krI3nTpCxw1lrONSbNCfS5ziBNjFhGezQApmwvfbW-wD3qW4gF182JbNmbBk7FKcsZkmSFsIVd6B9c7bErjGGUL2i382i4_hK_rizJTh7HWeot8317-u7qqHx9v7q8uHynLWLRV3Td-STgAl0krDjBoG2oEbqGRMtIartu8b1ksyEMNbXq42QJV1VkheqOYUnR96y61_95AXPftsYZpMgLjPmjEuWk6paAr64z90jPv13ZUqwqQ4UOxA2RRzTuD0LvnZpCdNiV6t61Gv1vVqXROhi_US-v5ave9nGN4jb5oLcHEAoLj45yHpbD0EC4NPxbAeov-o_wVqDZIz</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Schroeder, Harry W.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201908</creationdate><title>A role for maternal IgG in protecting infants from allergen-specific IgE sensitization</title><author>Schroeder, Harry W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-4f3b6085e107c7a2a9dd18efd172256a496bb32b70d0a464228ae19cfc574fd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age</topic><topic>Allergens</topic><topic>allergic sensitization</topic><topic>Allergies</topic><topic>Antigens</topic><topic>Atopy</topic><topic>Birth</topic><topic>Breastfeeding & lactation</topic><topic>Child</topic><topic>Children & youth</topic><topic>Disease</topic><topic>Disease prevention</topic><topic>fetal immune development</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immune System Diseases</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulins</topic><topic>Infant</topic><topic>Infants</topic><topic>maternal IgG</topic><topic>Microbiota</topic><topic>Mothers</topic><topic>ontogeny of the immune system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schroeder, Harry W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schroeder, Harry W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A role for maternal IgG in protecting infants from allergen-specific IgE sensitization</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2019-08</date><risdate>2019</risdate><volume>144</volume><issue>2</issue><spage>410</spage><epage>412</epage><pages>410-412</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><abstract>After birth, transfer is through the gut, which is less efficient. 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subjects | Age Allergens allergic sensitization Allergies Antigens Atopy Birth Breastfeeding & lactation Child Children & youth Disease Disease prevention fetal immune development Humans Immune system Immune System Diseases Immunoglobulin E Immunoglobulin G Immunoglobulins Infant Infants maternal IgG Microbiota Mothers ontogeny of the immune system |
title | A role for maternal IgG in protecting infants from allergen-specific IgE sensitization |
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