A role for maternal IgG in protecting infants from allergen-specific IgE sensitization

After birth, transfer is through the gut, which is less efficient. [...]the vast majority of maternally transmitted IgG is acquired before birth. A second finding was that children with IgE sensitization against a particular allergen also had significantly greater allergen-specific IgG levels to tha...

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Veröffentlicht in:Journal of allergy and clinical immunology 2019-08, Vol.144 (2), p.410-412
1. Verfasser: Schroeder, Harry W.
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description After birth, transfer is through the gut, which is less efficient. [...]the vast majority of maternally transmitted IgG is acquired before birth. A second finding was that children with IgE sensitization against a particular allergen also had significantly greater allergen-specific IgG levels to that same allergen. [...]endogenous production by the child of IgG against the allergen did not provide the protection given by maternal allergen-specific IgG. [...]the role of maternal IgG in manipulating the IgE or IgG response in patients with nonallergic conditions remains an open question.
doi_str_mv 10.1016/j.jaci.2019.05.039
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subjects Age
Allergens
allergic sensitization
Allergies
Antigens
Atopy
Birth
Breastfeeding & lactation
Child
Children & youth
Disease
Disease prevention
fetal immune development
Humans
Immune system
Immune System Diseases
Immunoglobulin E
Immunoglobulin G
Immunoglobulins
Infant
Infants
maternal IgG
Microbiota
Mothers
ontogeny of the immune system
title A role for maternal IgG in protecting infants from allergen-specific IgE sensitization
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