Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction

RATIONALE:Myofibroblasts have roles in tissue repair following damage associated with ischemia, aging, and inflammation and also promote fibrosis and tissue stiffening, causing organ dysfunction. One source of myofibroblasts is mesenchymal stromal/stem cells that exist as resident fibroblasts in mul...

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Veröffentlicht in:	Circulation research 2019-08, Vol.125 (4), p.414-430
Hauptverfasser:	Hara, Akitoshi, Kobayashi, Hiroki, Asai, Naoya, Saito, Shigeyoshi, Higuchi, Takahiro, Kato, Katsuhiro, Okumura, Takahiro, Bando, Yasuko K, Takefuji, Mikito, Mizutani, Yasuyuki, Miyai, Yuki, Saito, Shoji, Maruyama, Shoichi, Maeda, Keiko, Ouchi, Noriyuki, Nagasaka, Arata, Miyata, Takaki, Mii, Shinji, Kioka, Noriyuki, Worthley, Daniel L, Murohara, Toyoaki, Takahashi, Masahide, Enomoto, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured CHO Cells Collagen - genetics Collagen - metabolism Cricetinae Cricetulus Diastole HEK293 Cells Humans Immunoglobulins - genetics Immunoglobulins - metabolism Matrix Metalloproteinase 7 - metabolism Mesenchymal Stem Cells - metabolism Mice Mice, Inbred C57BL Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Myofibroblasts - metabolism Myofibroblasts - physiology Protein Binding Regeneration
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