miR-21-5p Suppressed the Sensitivity of Hepatocellular Carcinoma Cells to Cisplatin by Targeting FASLG

Accumulating evidence has suggested that microRNAs play important roles in the development of hepatocellular carcinoma (HCC) and are involved in drug resistance. miR-21-5p was overexpressed in a variety of cancers and promoted the tumorigenesis; however, the function of miR-21-5p in HCC still remain...

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Veröffentlicht in:	DNA and cell biology 2019-08, Vol.38 (8), p.865-873
Hauptverfasser:	Chen, Shifeng, Yang, Chunyun, Sun, Chengming, Sun, Yong, Yang, Zongjun, Cheng, Shaoyun, Zhuge, Baozhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antineoplastic Agents - pharmacology Apoptosis Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Cell proliferation Cisplatin Cisplatin - pharmacology Disease-Free Survival Drug resistance Drug Resistance, Neoplasm - genetics Fas Ligand Protein - genetics Fas Ligand Protein - metabolism FasL protein Female Gene Expression Regulation, Neoplastic - drug effects Hepatocellular carcinoma Humans Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - mortality Male Mice, Inbred BALB C MicroRNAs - genetics Middle Aged miRNA mRNA Sensitivity Tumorigenesis Xenograft Model Antitumor Assays
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