Synthesis and molecular modeling of novel non-sulfonylureas as hypoglycemic agents and selective ALR2 inhibitors

Compound (3e) exhibited 96 fold selective inhibitory activity against ALR2 versus ALR1, with an IC50 ± SEM value 0.37 ± 0.05 µM. [Display omitted] Novel non-sulfonylureas derivatives bearing an acetamide linker between a spirohydantoin scaffold and a phenyl ring were prepared and their hypoglycemic...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2019-08, Vol.27 (15), p.3383-3389
Hauptverfasser:	Salem, Manar G., Aziz, Yasmine M. Abdel, Elewa, Marwa, Elshihawy, Hosam A., Said, Mohamed M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldose reductase Hypoglycemic agents Meglitinides Non-sulfonylureas
Online-Zugang:	Volltext
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