Hexokinase-2 Glycolytic Overload in Diabetes and Ischemia–Reperfusion Injury

Hexokinase-2 (HK2) was recently found to produce increased metabolic flux through glycolysis in hyperglycemia without concurrent transcriptional or other functional regulation. Rather, stabilization to proteolysis by increased glucose substrate binding produced unscheduled increased glucose metaboli...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2019-07, Vol.30 (7), p.419-431
Hauptverfasser:	Rabbani, Naila, Thornalley, Paul J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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