Fatigue in children with perinatal stroke: clinical and neurophysiological associations
Aim To characterize fatigue in children with hemiparesis with perinatal stroke and explore associations with measures of motor performance and corticospinal excitability. Method Forty‐five children (16 females, 29 males), aged 6 to 18 years (mean [SD] 12y [4]), with magnetic resonance imaging‐confir...
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| Veröffentlicht in: | Developmental medicine and child neurology 2020-02, Vol.62 (2), p.234-240 |
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| creator | Wrightson, James G Zewdie, Ephrem Kuo, Hsing‐Ching Millet, Guillaume Y Kirton, Adam |
| description | Aim
To characterize fatigue in children with hemiparesis with perinatal stroke and explore associations with measures of motor performance and corticospinal excitability.
Method
Forty‐five children (16 females, 29 males), aged 6 to 18 years (mean [SD] 12y [4]), with magnetic resonance imaging‐confirmed perinatal stroke participated. Associations between fatigue (Pediatric Quality of Life Inventory Version 3.0 cerebral palsy module fatigue subscale), motor performance (Assisting Hand Assessment [AHA], Box and Blocks Test, grip strength), and excitability of corticospinal projections to both hands were examined using ranked tests of correlation, robust regression, and the Mann–Whitney U test.
Results
Nearly half of the participants (n=21) reported experiencing fatigue in the previous month. Function in the less affected hand (Box and Blocks Test, grip strength) was correlated with fatigue scores. Participants with preserved ipsilateral projections to the more affected hand had less fatigue, and scores correlated with the excitability of these projections. Fatigue scores were not associated with age, sex, or AHA score.
Interpretation
Fatigue is common in children with hemiparesis with perinatal stroke and is associated with motor performance and the presence and excitability of ipsilateral corticospinal projections from the contralesional hemisphere to the more affected hand.
What this paper adds
Fatigue is common in children with hemiparesis with perinatal stroke.
Fatigue was associated with motor performance and strength in the less affected, but not the more affected, hand.
Fatigue was associated with the presence and excitability of ipsilateral corticospinal projections from the contralesional hemisphere.
What this paper adds
Fatigue is common in children with hemiparesis with perinatal stroke.
Fatigue was associated with motor performance and strength in the less affected, but not the more affected, hand.
Fatigue was associated with the presence and excitability of ipsilateral corticospinal projections from the contralesional hemisphere.
This article is commented on by Stubberud on page 158 of this issue. |
| doi_str_mv | 10.1111/dmcn.14273 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2245619656</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2245619656</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3653-d3ab320bfd08ed186bc1a186bf58b91e1fc948a2e55796313b881c70f466628e3</originalsourceid><addsrcrecordid>eNp9kEFLwzAYhoMobk4v_gDpUYTOfEmbpt5kOhWmXhSPIU3TLdomM2kZ-_d2Vj36XV54eXj4eBE6BTyF_i7LRtkpJCSje2gMCctjniX5PhpjDCQGRsgIHYXwjjGmLE0O0YgCISSDbIze5rI1y05HxkZqZerSaxttTLuK1tobK1tZR6H17kNfRao21qi-kLaMrO68W6-2wbjaLYc6BKdM73M2HKODStZBn_zkBL3Ob19m9_Hi-e5hdr2IVf8KjUsqC0pwUZWY6xI4KxTIXVQpL3LQUKk84ZLoNM1yRoEWnIPKcJUwxgjXdILOB-_au89Oh1Y0Jihd19Jq1wVBSJIyyFnKevRiQJV3IXhdibU3jfRbAVjshhS7IcX3kD189uPtikaXf-jvcj0AA7Axtd7-oxI3j7OnQfoFcJZ-kQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2245619656</pqid></control><display><type>article</type><title>Fatigue in children with perinatal stroke: clinical and neurophysiological associations</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Wrightson, James G ; Zewdie, Ephrem ; Kuo, Hsing‐Ching ; Millet, Guillaume Y ; Kirton, Adam</creator><creatorcontrib>Wrightson, James G ; Zewdie, Ephrem ; Kuo, Hsing‐Ching ; Millet, Guillaume Y ; Kirton, Adam</creatorcontrib><description>Aim
To characterize fatigue in children with hemiparesis with perinatal stroke and explore associations with measures of motor performance and corticospinal excitability.
Method
Forty‐five children (16 females, 29 males), aged 6 to 18 years (mean [SD] 12y [4]), with magnetic resonance imaging‐confirmed perinatal stroke participated. Associations between fatigue (Pediatric Quality of Life Inventory Version 3.0 cerebral palsy module fatigue subscale), motor performance (Assisting Hand Assessment [AHA], Box and Blocks Test, grip strength), and excitability of corticospinal projections to both hands were examined using ranked tests of correlation, robust regression, and the Mann–Whitney U test.
Results
Nearly half of the participants (n=21) reported experiencing fatigue in the previous month. Function in the less affected hand (Box and Blocks Test, grip strength) was correlated with fatigue scores. Participants with preserved ipsilateral projections to the more affected hand had less fatigue, and scores correlated with the excitability of these projections. Fatigue scores were not associated with age, sex, or AHA score.
Interpretation
Fatigue is common in children with hemiparesis with perinatal stroke and is associated with motor performance and the presence and excitability of ipsilateral corticospinal projections from the contralesional hemisphere to the more affected hand.
What this paper adds
Fatigue is common in children with hemiparesis with perinatal stroke.
Fatigue was associated with motor performance and strength in the less affected, but not the more affected, hand.
Fatigue was associated with the presence and excitability of ipsilateral corticospinal projections from the contralesional hemisphere.
What this paper adds
Fatigue is common in children with hemiparesis with perinatal stroke.
Fatigue was associated with motor performance and strength in the less affected, but not the more affected, hand.
Fatigue was associated with the presence and excitability of ipsilateral corticospinal projections from the contralesional hemisphere.
This article is commented on by Stubberud on page 158 of this issue.</description><identifier>ISSN: 0012-1622</identifier><identifier>EISSN: 1469-8749</identifier><identifier>DOI: 10.1111/dmcn.14273</identifier><identifier>PMID: 31222717</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Child ; Cohort Studies ; Fatigue - etiology ; Fatigue - physiopathology ; Female ; Hand ; Humans ; Male ; Movement ; Paresis - etiology ; Paresis - physiopathology ; Pyramidal Tracts - physiopathology ; Stroke - complications ; Stroke - physiopathology</subject><ispartof>Developmental medicine and child neurology, 2020-02, Vol.62 (2), p.234-240</ispartof><rights>2019 Mac Keith Press</rights><rights>2019 Mac Keith Press.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3653-d3ab320bfd08ed186bc1a186bf58b91e1fc948a2e55796313b881c70f466628e3</citedby><cites>FETCH-LOGICAL-c3653-d3ab320bfd08ed186bc1a186bf58b91e1fc948a2e55796313b881c70f466628e3</cites><orcidid>0000-0001-5209-3374 ; 0000-0001-7106-7470 ; 0000-0002-7019-7895 ; 0000-0002-6395-0762 ; 0000-0003-1206-2471</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdmcn.14273$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdmcn.14273$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31222717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wrightson, James G</creatorcontrib><creatorcontrib>Zewdie, Ephrem</creatorcontrib><creatorcontrib>Kuo, Hsing‐Ching</creatorcontrib><creatorcontrib>Millet, Guillaume Y</creatorcontrib><creatorcontrib>Kirton, Adam</creatorcontrib><title>Fatigue in children with perinatal stroke: clinical and neurophysiological associations</title><title>Developmental medicine and child neurology</title><addtitle>Dev Med Child Neurol</addtitle><description>Aim
To characterize fatigue in children with hemiparesis with perinatal stroke and explore associations with measures of motor performance and corticospinal excitability.
Method
Forty‐five children (16 females, 29 males), aged 6 to 18 years (mean [SD] 12y [4]), with magnetic resonance imaging‐confirmed perinatal stroke participated. Associations between fatigue (Pediatric Quality of Life Inventory Version 3.0 cerebral palsy module fatigue subscale), motor performance (Assisting Hand Assessment [AHA], Box and Blocks Test, grip strength), and excitability of corticospinal projections to both hands were examined using ranked tests of correlation, robust regression, and the Mann–Whitney U test.
Results
Nearly half of the participants (n=21) reported experiencing fatigue in the previous month. Function in the less affected hand (Box and Blocks Test, grip strength) was correlated with fatigue scores. Participants with preserved ipsilateral projections to the more affected hand had less fatigue, and scores correlated with the excitability of these projections. Fatigue scores were not associated with age, sex, or AHA score.
Interpretation
Fatigue is common in children with hemiparesis with perinatal stroke and is associated with motor performance and the presence and excitability of ipsilateral corticospinal projections from the contralesional hemisphere to the more affected hand.
What this paper adds
Fatigue is common in children with hemiparesis with perinatal stroke.
Fatigue was associated with motor performance and strength in the less affected, but not the more affected, hand.
Fatigue was associated with the presence and excitability of ipsilateral corticospinal projections from the contralesional hemisphere.
What this paper adds
Fatigue is common in children with hemiparesis with perinatal stroke.
Fatigue was associated with motor performance and strength in the less affected, but not the more affected, hand.
Fatigue was associated with the presence and excitability of ipsilateral corticospinal projections from the contralesional hemisphere.
This article is commented on by Stubberud on page 158 of this issue.</description><subject>Adolescent</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Fatigue - etiology</subject><subject>Fatigue - physiopathology</subject><subject>Female</subject><subject>Hand</subject><subject>Humans</subject><subject>Male</subject><subject>Movement</subject><subject>Paresis - etiology</subject><subject>Paresis - physiopathology</subject><subject>Pyramidal Tracts - physiopathology</subject><subject>Stroke - complications</subject><subject>Stroke - physiopathology</subject><issn>0012-1622</issn><issn>1469-8749</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLwzAYhoMobk4v_gDpUYTOfEmbpt5kOhWmXhSPIU3TLdomM2kZ-_d2Vj36XV54eXj4eBE6BTyF_i7LRtkpJCSje2gMCctjniX5PhpjDCQGRsgIHYXwjjGmLE0O0YgCISSDbIze5rI1y05HxkZqZerSaxttTLuK1tobK1tZR6H17kNfRao21qi-kLaMrO68W6-2wbjaLYc6BKdM73M2HKODStZBn_zkBL3Ob19m9_Hi-e5hdr2IVf8KjUsqC0pwUZWY6xI4KxTIXVQpL3LQUKk84ZLoNM1yRoEWnIPKcJUwxgjXdILOB-_au89Oh1Y0Jihd19Jq1wVBSJIyyFnKevRiQJV3IXhdibU3jfRbAVjshhS7IcX3kD189uPtikaXf-jvcj0AA7Axtd7-oxI3j7OnQfoFcJZ-kQ</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Wrightson, James G</creator><creator>Zewdie, Ephrem</creator><creator>Kuo, Hsing‐Ching</creator><creator>Millet, Guillaume Y</creator><creator>Kirton, Adam</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5209-3374</orcidid><orcidid>https://orcid.org/0000-0001-7106-7470</orcidid><orcidid>https://orcid.org/0000-0002-7019-7895</orcidid><orcidid>https://orcid.org/0000-0002-6395-0762</orcidid><orcidid>https://orcid.org/0000-0003-1206-2471</orcidid></search><sort><creationdate>202002</creationdate><title>Fatigue in children with perinatal stroke: clinical and neurophysiological associations</title><author>Wrightson, James G ; Zewdie, Ephrem ; Kuo, Hsing‐Ching ; Millet, Guillaume Y ; Kirton, Adam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3653-d3ab320bfd08ed186bc1a186bf58b91e1fc948a2e55796313b881c70f466628e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Fatigue - etiology</topic><topic>Fatigue - physiopathology</topic><topic>Female</topic><topic>Hand</topic><topic>Humans</topic><topic>Male</topic><topic>Movement</topic><topic>Paresis - etiology</topic><topic>Paresis - physiopathology</topic><topic>Pyramidal Tracts - physiopathology</topic><topic>Stroke - complications</topic><topic>Stroke - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wrightson, James G</creatorcontrib><creatorcontrib>Zewdie, Ephrem</creatorcontrib><creatorcontrib>Kuo, Hsing‐Ching</creatorcontrib><creatorcontrib>Millet, Guillaume Y</creatorcontrib><creatorcontrib>Kirton, Adam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental medicine and child neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wrightson, James G</au><au>Zewdie, Ephrem</au><au>Kuo, Hsing‐Ching</au><au>Millet, Guillaume Y</au><au>Kirton, Adam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatigue in children with perinatal stroke: clinical and neurophysiological associations</atitle><jtitle>Developmental medicine and child neurology</jtitle><addtitle>Dev Med Child Neurol</addtitle><date>2020-02</date><risdate>2020</risdate><volume>62</volume><issue>2</issue><spage>234</spage><epage>240</epage><pages>234-240</pages><issn>0012-1622</issn><eissn>1469-8749</eissn><abstract>Aim
To characterize fatigue in children with hemiparesis with perinatal stroke and explore associations with measures of motor performance and corticospinal excitability.
Method
Forty‐five children (16 females, 29 males), aged 6 to 18 years (mean [SD] 12y [4]), with magnetic resonance imaging‐confirmed perinatal stroke participated. Associations between fatigue (Pediatric Quality of Life Inventory Version 3.0 cerebral palsy module fatigue subscale), motor performance (Assisting Hand Assessment [AHA], Box and Blocks Test, grip strength), and excitability of corticospinal projections to both hands were examined using ranked tests of correlation, robust regression, and the Mann–Whitney U test.
Results
Nearly half of the participants (n=21) reported experiencing fatigue in the previous month. Function in the less affected hand (Box and Blocks Test, grip strength) was correlated with fatigue scores. Participants with preserved ipsilateral projections to the more affected hand had less fatigue, and scores correlated with the excitability of these projections. Fatigue scores were not associated with age, sex, or AHA score.
Interpretation
Fatigue is common in children with hemiparesis with perinatal stroke and is associated with motor performance and the presence and excitability of ipsilateral corticospinal projections from the contralesional hemisphere to the more affected hand.
What this paper adds
Fatigue is common in children with hemiparesis with perinatal stroke.
Fatigue was associated with motor performance and strength in the less affected, but not the more affected, hand.
Fatigue was associated with the presence and excitability of ipsilateral corticospinal projections from the contralesional hemisphere.
What this paper adds
Fatigue is common in children with hemiparesis with perinatal stroke.
Fatigue was associated with motor performance and strength in the less affected, but not the more affected, hand.
Fatigue was associated with the presence and excitability of ipsilateral corticospinal projections from the contralesional hemisphere.
This article is commented on by Stubberud on page 158 of this issue.</abstract><cop>England</cop><pmid>31222717</pmid><doi>10.1111/dmcn.14273</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5209-3374</orcidid><orcidid>https://orcid.org/0000-0001-7106-7470</orcidid><orcidid>https://orcid.org/0000-0002-7019-7895</orcidid><orcidid>https://orcid.org/0000-0002-6395-0762</orcidid><orcidid>https://orcid.org/0000-0003-1206-2471</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Developmental medicine and child neurology, 2020-02, Vol.62 (2), p.234-240 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Child Cohort Studies Fatigue - etiology Fatigue - physiopathology Female Hand Humans Male Movement Paresis - etiology Paresis - physiopathology Pyramidal Tracts - physiopathology Stroke - complications Stroke - physiopathology |
| title | Fatigue in children with perinatal stroke: clinical and neurophysiological associations |
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