Targeting STAT3 inhibition to reverse cisplatin resistance

[Display omitted] •The intrinsic or acquired resistance to cisplatin remains a major obstacle for cancer therapy.•STAT3 is important for mediating drug resistance in cancer treatment.•STAT3 inhibitors have the ability to enhance the anti-tumor efficacy of cisplatin. Cisplatin is one of the most freq...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-09, Vol.117, p.109135-109135, Article 109135
Hauptverfasser:	Sun, Chao-Yue, Nie, Juan, Huang, Jie-Peng, Zheng, Guang-Juan, Feng, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Cisplatin Cisplatin - pharmacology Cisplatin - therapeutic use Drug Resistance, Neoplasm - drug effects Humans Models, Biological Neoplasms - drug therapy Neoplasms - pathology Resistance STAT3 STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism
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