Gastrodin Inhibits Inflammasome Through the STAT3 Signal Pathways in TNA2 Astrocytes and Reactive Astrocytes in Experimentally Induced Cerebral Ischemia in Rats

This study was aimed to determine Gastrodin (GAS) and its underlying signaling pathway involved in suppression of inflammasome specifically in reactive astrocytes that are featured prominently in different neurological conditions or diseases including cerebral ischemia. For this purpose, TNA2 astroc...

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Veröffentlicht in:	Neuromolecular medicine 2019-09, Vol.21 (3), p.275-286
Hauptverfasser:	Sui, Yue, Bian, Ligong, Ai, Qinglong, Yao, Yueyi, Yu, Mali, Gao, Huiqing, Zhang, Aidan, Fu, Xiyue, Zhong, Lianmei, Lu, Di
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Astrocytes - classification Astrocytes - drug effects Astrocytes - metabolism Benzyl Alcohols - administration & dosage Benzyl Alcohols - pharmacology Benzyl Alcohols - therapeutic use Biomarkers Biomedical and Life Sciences Biomedicine Caspase Caspase-1 Cell Line, Transformed Cells, Cultured Cerebral blood flow Drug Evaluation, Preclinical Glucose - pharmacology Glucosides - administration & dosage Glucosides - pharmacology Glucosides - therapeutic use Hypoxia Hypoxia-Ischemia, Brain - drug therapy Immunofluorescence Infarction, Middle Cerebral Artery - complications Inflammasomes Inflammasomes - drug effects Inflammation Interleukin 18 Internal Medicine Ischemia Kinases Male Mimicry Nerve Tissue Proteins - physiology Neurology Neuroprotective Agents - administration & dosage Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurosciences NF-kappa B - metabolism NF-κB protein Original Paper Oxygen - pharmacology Phytotherapy Premedication Rats Rats, Sprague-Dawley Signal transduction Signal Transduction - drug effects Stat3 protein STAT3 Transcription Factor - physiology
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