Aggregate Forms of Recombinant Human Erythropoietin With Different Charge Profile Substantially Impact Biological Activities

Recombinant human erythropoietin (rHuEPO) as a glycoprotein growth factor has been considered a biological drug for treatment of anemic patients with chronic renal failure or who receive cancer chemotherapy. Biological activity and circulation time are 2 parameters that are important to achieve EPO’...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2020-01, Vol.109 (1), p.277-283
Hauptverfasser:	Ghezlou, Mansoureh, Mokhtari, Farzad, Kalbasi, Alireza, Riazi, Gholamhossein, Kaghazian, Hooman, Emadi, Reza, Aref, Amir Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	aggregation Animals biological activity Dynamic Light Scattering Electrophoresis, Capillary erythropoietin Erythropoietin - chemistry Erythropoietin - pharmacology Glycosylation I-number Injections, Subcutaneous Mice N-Acetylneuraminic Acid - analysis Particle Size Protein Aggregates Protein Structure, Secondary Protein Structure, Tertiary Recombinant Proteins - chemistry Recombinant Proteins - pharmacology Reticulocytes - drug effects
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