Gold nanoparticles regulate tight junctions and improve cetuximab effect in colon cancer cells
Colon cancer (CC) is the second cause of cancer death worldwide. The use of nanoparticles for drug delivery has been increasing in cancer clinical trials over recent years. We evaluated cytotoxicity of citrate-capped gold nanoparticles (GNPs) and the role they play on cell–cell adhesion. We also use...
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2019-06, Vol.14 (12), p.1565-1578 |
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| creator | Leve, Fernanda Bonfim, Daniella P Fontes, Giselle Morgado-Díaz, José A |
| description | Colon cancer (CC) is the second cause of cancer death worldwide. The use of nanoparticles for drug delivery has been increasing in cancer clinical trials over recent years.
We evaluated cytotoxicity of citrate-capped gold nanoparticles (GNPs) and the role they play on cell–cell adhesion. We also used GNP for delivery of cetuximab into different CC cell lines.
CC cells with well-formed tight junctions impair GNP uptake. Noncytotoxic concentration of GNP increases paracellular permeability in Caco-2 cells in a reversible way, concomitantly to tight junctions proteins CLDN1 and ZO-1 redistribution. GNP functionalized with cetuximab increases death of invasive HCT-116 CC cells.
GNP can be used for drug delivery and can improve efficiency of CC therapy. |
| doi_str_mv | 10.2217/nnm-2019-0023 |
| format | Article |
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We evaluated cytotoxicity of citrate-capped gold nanoparticles (GNPs) and the role they play on cell–cell adhesion. We also used GNP for delivery of cetuximab into different CC cell lines.
CC cells with well-formed tight junctions impair GNP uptake. Noncytotoxic concentration of GNP increases paracellular permeability in Caco-2 cells in a reversible way, concomitantly to tight junctions proteins CLDN1 and ZO-1 redistribution. GNP functionalized with cetuximab increases death of invasive HCT-116 CC cells.
GNP can be used for drug delivery and can improve efficiency of CC therapy.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm-2019-0023</identifier><identifier>PMID: 31215349</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Autophagy ; Cancer therapies ; Cell adhesion & migration ; cell–cell adhesion ; cetuximab ; colon cancer ; Colorectal cancer ; Cytotoxicity ; Drug delivery systems ; EGFR ; gold nanoparticle ; Immunoglobulins ; Immunotherapy ; Investigations ; Lung cancer ; Monoclonal antibodies ; Mutation ; Nanoparticles ; Permeability ; Physiology ; Proteins ; Regulatory approval ; Targeted cancer therapy ; tight junction ; Tumors</subject><ispartof>Nanomedicine (London, England), 2019-06, Vol.14 (12), p.1565-1578</ispartof><rights>2019 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Jun 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-16d6950bb37b261ab9fa6bff7deca4ed059c68830ef23fee3878a5f26e7f464f3</citedby><cites>FETCH-LOGICAL-c371t-16d6950bb37b261ab9fa6bff7deca4ed059c68830ef23fee3878a5f26e7f464f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31215349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leve, Fernanda</creatorcontrib><creatorcontrib>Bonfim, Daniella P</creatorcontrib><creatorcontrib>Fontes, Giselle</creatorcontrib><creatorcontrib>Morgado-Díaz, José A</creatorcontrib><title>Gold nanoparticles regulate tight junctions and improve cetuximab effect in colon cancer cells</title><title>Nanomedicine (London, England)</title><addtitle>Nanomedicine (Lond)</addtitle><description>Colon cancer (CC) is the second cause of cancer death worldwide. The use of nanoparticles for drug delivery has been increasing in cancer clinical trials over recent years.
We evaluated cytotoxicity of citrate-capped gold nanoparticles (GNPs) and the role they play on cell–cell adhesion. We also used GNP for delivery of cetuximab into different CC cell lines.
CC cells with well-formed tight junctions impair GNP uptake. Noncytotoxic concentration of GNP increases paracellular permeability in Caco-2 cells in a reversible way, concomitantly to tight junctions proteins CLDN1 and ZO-1 redistribution. GNP functionalized with cetuximab increases death of invasive HCT-116 CC cells.
GNP can be used for drug delivery and can improve efficiency of CC therapy.</description><subject>Autophagy</subject><subject>Cancer therapies</subject><subject>Cell adhesion & migration</subject><subject>cell–cell adhesion</subject><subject>cetuximab</subject><subject>colon cancer</subject><subject>Colorectal cancer</subject><subject>Cytotoxicity</subject><subject>Drug delivery systems</subject><subject>EGFR</subject><subject>gold nanoparticle</subject><subject>Immunoglobulins</subject><subject>Immunotherapy</subject><subject>Investigations</subject><subject>Lung cancer</subject><subject>Monoclonal antibodies</subject><subject>Mutation</subject><subject>Nanoparticles</subject><subject>Permeability</subject><subject>Physiology</subject><subject>Proteins</subject><subject>Regulatory approval</subject><subject>Targeted cancer therapy</subject><subject>tight junction</subject><subject>Tumors</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kEtrFTEYhoNY7EWXbiXgxs1oLpPLLKXUWii4abeGTOZLzWEmOeYi9t-b46kuBDdJPnjy8n4PQq8pec8YVR9i3AZG6DQQwvgzdEbVqAc5Sf7895sPQuvpFJ2XsiNEaEbJC3TKKaOCj9MZ-nqd1gVHG9Pe5hrcCgVneGirrYBrePhW8a5FV0OKBdu44LDtc_oB2EFtP8NmZwzeg6s4ROzSmvppo4PcgXUtL9GJt2uBV0_3Bbr_dHV3-Xm4_XJ9c_nxdnBc0TpQuchJkHnmamaS2nnyVs7eqwWcHWEhYnJSa07AM-4BuFbaCs8kKD_K0fML9O6Y28t9b1Cq2UI5NLARUiuGsbGvqwSTHX37D7pLLcferlNKKi2kGDs1HCmXUykZvNnnvm1-NJSYg3jTxZuDeHMQ3_k3T6lt3mD5S_8x3YHpCPhWW4biAnRN5jj1H8GFCP8J_wXhKZMx</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Leve, Fernanda</creator><creator>Bonfim, Daniella P</creator><creator>Fontes, Giselle</creator><creator>Morgado-Díaz, José A</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>Gold nanoparticles regulate tight junctions and improve cetuximab effect in colon cancer cells</title><author>Leve, Fernanda ; Bonfim, Daniella P ; Fontes, Giselle ; Morgado-Díaz, José A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-16d6950bb37b261ab9fa6bff7deca4ed059c68830ef23fee3878a5f26e7f464f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Autophagy</topic><topic>Cancer therapies</topic><topic>Cell adhesion & migration</topic><topic>cell–cell adhesion</topic><topic>cetuximab</topic><topic>colon cancer</topic><topic>Colorectal cancer</topic><topic>Cytotoxicity</topic><topic>Drug delivery systems</topic><topic>EGFR</topic><topic>gold nanoparticle</topic><topic>Immunoglobulins</topic><topic>Immunotherapy</topic><topic>Investigations</topic><topic>Lung cancer</topic><topic>Monoclonal antibodies</topic><topic>Mutation</topic><topic>Nanoparticles</topic><topic>Permeability</topic><topic>Physiology</topic><topic>Proteins</topic><topic>Regulatory approval</topic><topic>Targeted cancer therapy</topic><topic>tight junction</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leve, Fernanda</creatorcontrib><creatorcontrib>Bonfim, Daniella P</creatorcontrib><creatorcontrib>Fontes, Giselle</creatorcontrib><creatorcontrib>Morgado-Díaz, José A</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Nanomedicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leve, Fernanda</au><au>Bonfim, Daniella P</au><au>Fontes, Giselle</au><au>Morgado-Díaz, José A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gold nanoparticles regulate tight junctions and improve cetuximab effect in colon cancer cells</atitle><jtitle>Nanomedicine (London, England)</jtitle><addtitle>Nanomedicine (Lond)</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>14</volume><issue>12</issue><spage>1565</spage><epage>1578</epage><pages>1565-1578</pages><issn>1743-5889</issn><eissn>1748-6963</eissn><abstract>Colon cancer (CC) is the second cause of cancer death worldwide. The use of nanoparticles for drug delivery has been increasing in cancer clinical trials over recent years.
We evaluated cytotoxicity of citrate-capped gold nanoparticles (GNPs) and the role they play on cell–cell adhesion. We also used GNP for delivery of cetuximab into different CC cell lines.
CC cells with well-formed tight junctions impair GNP uptake. Noncytotoxic concentration of GNP increases paracellular permeability in Caco-2 cells in a reversible way, concomitantly to tight junctions proteins CLDN1 and ZO-1 redistribution. GNP functionalized with cetuximab increases death of invasive HCT-116 CC cells.
GNP can be used for drug delivery and can improve efficiency of CC therapy.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>31215349</pmid><doi>10.2217/nnm-2019-0023</doi><tpages>14</tpages></addata></record> |
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| source | PubMed Central |
| subjects | Autophagy Cancer therapies Cell adhesion & migration cell–cell adhesion cetuximab colon cancer Colorectal cancer Cytotoxicity Drug delivery systems EGFR gold nanoparticle Immunoglobulins Immunotherapy Investigations Lung cancer Monoclonal antibodies Mutation Nanoparticles Permeability Physiology Proteins Regulatory approval Targeted cancer therapy tight junction Tumors |
| title | Gold nanoparticles regulate tight junctions and improve cetuximab effect in colon cancer cells |
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