microRNA-126 inhibits tube formation of HUVECs by interacting with EGFL7 and down-regulating PI3K/AKT signaling pathway

It's critical for tube formation and angiogenesis to repair ischemic myocardium or stroke. This study aimed to investigate role of microRNA-126 (miR-126) in tube formation in human umbilical vein endothelial cells (HUVECs) and associated mechanisms. Primary neural stem cells (NSCs) and HUVECs w...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-08, Vol.116, p.109007-109007, Article 109007
Hauptverfasser:	Li, Qiang, Cheng, Kai, Wang, Ai-Yue, Xu, Qiong-Guang, Fu, Zhou-Feng, He, Shao-Yu, Xu, Peng-Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD34 - metabolism Atorvastatin - administration & dosage Atorvastatin - pharmacology Base Sequence Brain Injuries, Traumatic - genetics Brain Injuries, Traumatic - pathology Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cell Cycle - drug effects Cell Cycle - genetics Cell Survival - drug effects Cell Survival - genetics Down-Regulation - drug effects Down-Regulation - genetics EGF Family of Proteins - genetics EGF Family of Proteins - metabolism EGFL7 Endothelial Growth Factors - metabolism Human Umbilical Vein Endothelial Cells - metabolism Humans microRNA-126 MicroRNAs - genetics MicroRNAs - metabolism Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - genetics Neural Stem Cells - drug effects Neural Stem Cells - metabolism Phosphatidylinositol 3-Kinases - metabolism PI3K/AKT signaling pathway Proto-Oncogene Proteins c-akt - metabolism Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Tube formation Up-Regulation - drug effects Up-Regulation - genetics
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