Baicalin regulates depression behavior in mice exposed to chronic mild stress via the Rac/LIMK/cofilin pathway

[Display omitted] •The antidepressant effect of baicalin on chronic unpredictability stress mice was confirmed.•The antidepressant effect of baicalin was mediated by improved neuroplasticity.•Baicalin improved neuroplasticity by affecting the expressions of BDNF, thereby activating the Rac-Limk-cofi...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-08, Vol.116, p.109054-109054, Article 109054
Hauptverfasser:	Lu, Ye, Sun, Guoqiang, Yang, Fan, Guan, Zhenwei, Zhang, Zui, Zhao, Jing, Liu, Yongyong, Chu, Li, Pei, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Depolymerizing Factors - metabolism Animals Baicalin Behavior, Animal - drug effects Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Chronic Disease Cofilin Depression Depression - complications Depression - drug therapy Disks Large Homolog 4 Protein - genetics Disks Large Homolog 4 Protein - metabolism Flavonoids - chemistry Flavonoids - pharmacology Flavonoids - therapeutic use Hippocampus - drug effects Hippocampus - pathology Hippocampus - ultrastructure Lim Kinases - metabolism Male Mice Neurons - drug effects Neurons - pathology Neurons - ultrastructure rac GTP-Binding Proteins - metabolism Rac1 Receptor, trkB - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects Stress, Psychological - complications Stress, Psychological - drug therapy Swimming Synaptic plasticity Synaptophysin - genetics Synaptophysin - metabolism
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