IL-15 in autoimmunity and cancer: O-tu-b or not O-tu-b?

The cytokine IL-15 controls the homeostasis and activation of CD8 + T cells and natural killer cells. A new study reveals the deubiquitinase Otub1 to be a negative regulator of IL-15 signaling, with important consequences for autoimmunity and anti-cancer immunity.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2019-07, Vol.20 (7), p.780-782
1. Verfasser:	Moynagh, Paul N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Autoimmunity Biomedical and Life Sciences Biomedicine Cancer CD8 antigen CD8-Positive T-Lymphocytes Cell activation Cytokines Deubiquitinating Enzymes Genomes Homeostasis Humans Immune response Immunology Infectious Diseases Interleukin 15 Killer cells Killer Cells, Natural Kinases Localization Lymphocytes Lymphocytes T Metabolism Natural killer cells Neoplasms News & Views news-and-views Pathogens Phosphorylation T cells Transcription factors
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Beschreibung
Zusammenfassung:	The cytokine IL-15 controls the homeostasis and activation of CD8 + T cells and natural killer cells. A new study reveals the deubiquitinase Otub1 to be a negative regulator of IL-15 signaling, with important consequences for autoimmunity and anti-cancer immunity.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/s41590-019-0424-z