Low levels of pannexin‐1 in Behçet’s syndrome
Objective Behçet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation, in the inflammatory process of BS, with...
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| Veröffentlicht in: | International journal of rheumatic diseases 2019-08, Vol.22 (8), p.1474-1478 |
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| container_title | International journal of rheumatic diseases |
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| creator | Şahin, Ali İlhan, Abdullah Derin, Mehmet Emin Doğan, Halef Okan Şahin, Mehtap |
| description | Objective
Behçet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation, in the inflammatory process of BS, with healthy subjects, to investigate their level in patients and their relationship with the clinical findings.
Method
Forty‐six patients who were under follow‐up for BS in the Sivas Cumhuriyet University Medical Faculty Department of Internal Diseases, Rheumatology Unit, between January 2017 and June 2017 and 44 healthy controls (HC) who did not have any rheumatic, systemic or metabolic diseases, were enrolled in this study.
Results
The mean serum pannexin‐1 level was 6.36 (4.21‐527.2) pg/mL in the BS group and 255.8 (5.38‐2000) pg/mL in the HC group. Serum pannexin‐1 levels were statistically significantly lower in the BS group (P |
| doi_str_mv | 10.1111/1756-185X.13614 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2242826710</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2268451120</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3714-7c6f4f908e12df3b3b4539d8a9327fffb6c288b1b99982634f1aea66b2d3e37c3</originalsourceid><addsrcrecordid>eNqFkDtOw0AQhlcIREKgpkOWaGiceHbXa7sMES_JEhQg0a38mBWO_AjeOCFdjkDLCTgIN8lJWOOQgoZpZjT65tfoI-QUnCGYGoHnCht893kITADfI_3dZn83c-iRI62njiMM5R2SHgMK4DqsT2hYLa0cF5hrq1LWLCpLfMvKzfodrKy0LvHl6xPnm_WHtvSqTOuqwGNyoKJc48m2D8jT9dXj5NYO72_uJuPQTpgH3PYSobgKHB-BporFLOYuC1I_Chj1lFKxSKjvxxAHQeBTwbiCCCMhYpoyZF7CBuSiy53V1WuDei6LTCeY51GJVaMlpZyaQw8cg57_QadVU5fmO0MJn7sAtKVGHZXUldY1KjmrsyKqVxIc2eqUrTDZypM_Os3F2Ta3iQtMd_yvPwO4HbDMclz9lyfHD2EX_A08In8h</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2268451120</pqid></control><display><type>article</type><title>Low levels of pannexin‐1 in Behçet’s syndrome</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Şahin, Ali ; İlhan, Abdullah ; Derin, Mehmet Emin ; Doğan, Halef Okan ; Şahin, Mehtap</creator><creatorcontrib>Şahin, Ali ; İlhan, Abdullah ; Derin, Mehmet Emin ; Doğan, Halef Okan ; Şahin, Mehtap</creatorcontrib><description>Objective
Behçet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation, in the inflammatory process of BS, with healthy subjects, to investigate their level in patients and their relationship with the clinical findings.
Method
Forty‐six patients who were under follow‐up for BS in the Sivas Cumhuriyet University Medical Faculty Department of Internal Diseases, Rheumatology Unit, between January 2017 and June 2017 and 44 healthy controls (HC) who did not have any rheumatic, systemic or metabolic diseases, were enrolled in this study.
Results
The mean serum pannexin‐1 level was 6.36 (4.21‐527.2) pg/mL in the BS group and 255.8 (5.38‐2000) pg/mL in the HC group. Serum pannexin‐1 levels were statistically significantly lower in the BS group (P < 0.0001). The measured mean serum caspase‐3 level was 12.04 (11.25‐43.69) pg/mL in the group with BS and 12.1 (11.19‐484.3) pg/mL in the HC group (P = 0.143), mean serum caspase‐9 level was 22 (5.14‐29.33) pg/mL in the BS group and 22.01 (11.23‐850) pg/mL in the HC group (P = 0.593), mean serum caspase‐14 level was 6 (5.2‐8.21) pg/mL in the BS group and 6.15 (5.7‐353) pg/mL in the HC group (P = 0.053).
Conclusion
Comparison of serum caspase‐3, caspase‐9 and caspase‐14 levels in subjects with BS and in the HC group did not reveal any statistically significant differences. On the other hand, serum pannexin‐1 levels were statistically significantly lower in the BS group.</description><identifier>ISSN: 1756-1841</identifier><identifier>EISSN: 1756-185X</identifier><identifier>DOI: 10.1111/1756-185X.13614</identifier><identifier>PMID: 31211503</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Behcet Syndrome - blood ; Behcet Syndrome - diagnosis ; Behçet’s syndrome ; Biomarkers - blood ; Case-Control Studies ; Caspase ; Caspase 3 - blood ; Caspase 9 - blood ; caspases ; Caspases - blood ; Connexins - blood ; Down-Regulation ; Female ; Humans ; Inflammation ; Male ; Metabolic disorders ; Nerve Tissue Proteins - blood ; pannexin‐1 ; Patients ; Rheumatology ; Statistical analysis ; Turkey ; Vein & artery diseases</subject><ispartof>International journal of rheumatic diseases, 2019-08, Vol.22 (8), p.1474-1478</ispartof><rights>2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd</rights><rights>2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.</rights><rights>International Journal of Rheumatic Diseases © 2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3714-7c6f4f908e12df3b3b4539d8a9327fffb6c288b1b99982634f1aea66b2d3e37c3</citedby><cites>FETCH-LOGICAL-c3714-7c6f4f908e12df3b3b4539d8a9327fffb6c288b1b99982634f1aea66b2d3e37c3</cites><orcidid>0000-0002-6953-4276 ; 0000-0002-0471-7047 ; 0000-0002-8830-8848 ; 0000-0003-4518-6489 ; 0000-0001-8738-0760</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1756-185X.13614$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1756-185X.13614$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31211503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Şahin, Ali</creatorcontrib><creatorcontrib>İlhan, Abdullah</creatorcontrib><creatorcontrib>Derin, Mehmet Emin</creatorcontrib><creatorcontrib>Doğan, Halef Okan</creatorcontrib><creatorcontrib>Şahin, Mehtap</creatorcontrib><title>Low levels of pannexin‐1 in Behçet’s syndrome</title><title>International journal of rheumatic diseases</title><addtitle>Int J Rheum Dis</addtitle><description>Objective
Behçet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation, in the inflammatory process of BS, with healthy subjects, to investigate their level in patients and their relationship with the clinical findings.
Method
Forty‐six patients who were under follow‐up for BS in the Sivas Cumhuriyet University Medical Faculty Department of Internal Diseases, Rheumatology Unit, between January 2017 and June 2017 and 44 healthy controls (HC) who did not have any rheumatic, systemic or metabolic diseases, were enrolled in this study.
Results
The mean serum pannexin‐1 level was 6.36 (4.21‐527.2) pg/mL in the BS group and 255.8 (5.38‐2000) pg/mL in the HC group. Serum pannexin‐1 levels were statistically significantly lower in the BS group (P < 0.0001). The measured mean serum caspase‐3 level was 12.04 (11.25‐43.69) pg/mL in the group with BS and 12.1 (11.19‐484.3) pg/mL in the HC group (P = 0.143), mean serum caspase‐9 level was 22 (5.14‐29.33) pg/mL in the BS group and 22.01 (11.23‐850) pg/mL in the HC group (P = 0.593), mean serum caspase‐14 level was 6 (5.2‐8.21) pg/mL in the BS group and 6.15 (5.7‐353) pg/mL in the HC group (P = 0.053).
Conclusion
Comparison of serum caspase‐3, caspase‐9 and caspase‐14 levels in subjects with BS and in the HC group did not reveal any statistically significant differences. On the other hand, serum pannexin‐1 levels were statistically significantly lower in the BS group.</description><subject>Adult</subject><subject>Behcet Syndrome - blood</subject><subject>Behcet Syndrome - diagnosis</subject><subject>Behçet’s syndrome</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Caspase</subject><subject>Caspase 3 - blood</subject><subject>Caspase 9 - blood</subject><subject>caspases</subject><subject>Caspases - blood</subject><subject>Connexins - blood</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Nerve Tissue Proteins - blood</subject><subject>pannexin‐1</subject><subject>Patients</subject><subject>Rheumatology</subject><subject>Statistical analysis</subject><subject>Turkey</subject><subject>Vein & artery diseases</subject><issn>1756-1841</issn><issn>1756-185X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtOw0AQhlcIREKgpkOWaGiceHbXa7sMES_JEhQg0a38mBWO_AjeOCFdjkDLCTgIN8lJWOOQgoZpZjT65tfoI-QUnCGYGoHnCht893kITADfI_3dZn83c-iRI62njiMM5R2SHgMK4DqsT2hYLa0cF5hrq1LWLCpLfMvKzfodrKy0LvHl6xPnm_WHtvSqTOuqwGNyoKJc48m2D8jT9dXj5NYO72_uJuPQTpgH3PYSobgKHB-BporFLOYuC1I_Chj1lFKxSKjvxxAHQeBTwbiCCCMhYpoyZF7CBuSiy53V1WuDei6LTCeY51GJVaMlpZyaQw8cg57_QadVU5fmO0MJn7sAtKVGHZXUldY1KjmrsyKqVxIc2eqUrTDZypM_Os3F2Ta3iQtMd_yvPwO4HbDMclz9lyfHD2EX_A08In8h</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Şahin, Ali</creator><creator>İlhan, Abdullah</creator><creator>Derin, Mehmet Emin</creator><creator>Doğan, Halef Okan</creator><creator>Şahin, Mehtap</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6953-4276</orcidid><orcidid>https://orcid.org/0000-0002-0471-7047</orcidid><orcidid>https://orcid.org/0000-0002-8830-8848</orcidid><orcidid>https://orcid.org/0000-0003-4518-6489</orcidid><orcidid>https://orcid.org/0000-0001-8738-0760</orcidid></search><sort><creationdate>201908</creationdate><title>Low levels of pannexin‐1 in Behçet’s syndrome</title><author>Şahin, Ali ; İlhan, Abdullah ; Derin, Mehmet Emin ; Doğan, Halef Okan ; Şahin, Mehtap</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3714-7c6f4f908e12df3b3b4539d8a9327fffb6c288b1b99982634f1aea66b2d3e37c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Behcet Syndrome - blood</topic><topic>Behcet Syndrome - diagnosis</topic><topic>Behçet’s syndrome</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Caspase</topic><topic>Caspase 3 - blood</topic><topic>Caspase 9 - blood</topic><topic>caspases</topic><topic>Caspases - blood</topic><topic>Connexins - blood</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>Nerve Tissue Proteins - blood</topic><topic>pannexin‐1</topic><topic>Patients</topic><topic>Rheumatology</topic><topic>Statistical analysis</topic><topic>Turkey</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Şahin, Ali</creatorcontrib><creatorcontrib>İlhan, Abdullah</creatorcontrib><creatorcontrib>Derin, Mehmet Emin</creatorcontrib><creatorcontrib>Doğan, Halef Okan</creatorcontrib><creatorcontrib>Şahin, Mehtap</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Şahin, Ali</au><au>İlhan, Abdullah</au><au>Derin, Mehmet Emin</au><au>Doğan, Halef Okan</au><au>Şahin, Mehtap</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low levels of pannexin‐1 in Behçet’s syndrome</atitle><jtitle>International journal of rheumatic diseases</jtitle><addtitle>Int J Rheum Dis</addtitle><date>2019-08</date><risdate>2019</risdate><volume>22</volume><issue>8</issue><spage>1474</spage><epage>1478</epage><pages>1474-1478</pages><issn>1756-1841</issn><eissn>1756-185X</eissn><abstract>Objective
Behçet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation, in the inflammatory process of BS, with healthy subjects, to investigate their level in patients and their relationship with the clinical findings.
Method
Forty‐six patients who were under follow‐up for BS in the Sivas Cumhuriyet University Medical Faculty Department of Internal Diseases, Rheumatology Unit, between January 2017 and June 2017 and 44 healthy controls (HC) who did not have any rheumatic, systemic or metabolic diseases, were enrolled in this study.
Results
The mean serum pannexin‐1 level was 6.36 (4.21‐527.2) pg/mL in the BS group and 255.8 (5.38‐2000) pg/mL in the HC group. Serum pannexin‐1 levels were statistically significantly lower in the BS group (P < 0.0001). The measured mean serum caspase‐3 level was 12.04 (11.25‐43.69) pg/mL in the group with BS and 12.1 (11.19‐484.3) pg/mL in the HC group (P = 0.143), mean serum caspase‐9 level was 22 (5.14‐29.33) pg/mL in the BS group and 22.01 (11.23‐850) pg/mL in the HC group (P = 0.593), mean serum caspase‐14 level was 6 (5.2‐8.21) pg/mL in the BS group and 6.15 (5.7‐353) pg/mL in the HC group (P = 0.053).
Conclusion
Comparison of serum caspase‐3, caspase‐9 and caspase‐14 levels in subjects with BS and in the HC group did not reveal any statistically significant differences. On the other hand, serum pannexin‐1 levels were statistically significantly lower in the BS group.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31211503</pmid><doi>10.1111/1756-185X.13614</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-6953-4276</orcidid><orcidid>https://orcid.org/0000-0002-0471-7047</orcidid><orcidid>https://orcid.org/0000-0002-8830-8848</orcidid><orcidid>https://orcid.org/0000-0003-4518-6489</orcidid><orcidid>https://orcid.org/0000-0001-8738-0760</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Behcet Syndrome - blood Behcet Syndrome - diagnosis Behçet’s syndrome Biomarkers - blood Case-Control Studies Caspase Caspase 3 - blood Caspase 9 - blood caspases Caspases - blood Connexins - blood Down-Regulation Female Humans Inflammation Male Metabolic disorders Nerve Tissue Proteins - blood pannexin‐1 Patients Rheumatology Statistical analysis Turkey Vein & artery diseases |
| title | Low levels of pannexin‐1 in Behçet’s syndrome |
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