The role of NMDA receptor in neurobiology and treatment of major depressive disorder: Evidence from translational research

There is accumulating evidence demonstrating that dysfunction of glutamatergic neurotransmission, particularly via N-methyl-d-aspartate (NMDA) receptors, is involved in the pathophysiology of major depressive disorder (MDD). Several studies have revealed an altered expression of NMDA receptor subtyp...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 2019-08, Vol.94, p.109668-109668, Article 109668
Hauptverfasser:	Amidfar, Meysam, Woelfer, Marie, Réus, Gislaine Z., Quevedo, João, Walter, Martin, Kim, Yong-Ku
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Depressive Disorder, Major - drug therapy Depressive Disorder, Major - physiopathology Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use Humans Ketamine Major depressive disorder Memantine Neuronal Plasticity - drug effects NMDA receptor Receptors, N-Methyl-D-Aspartate - physiology Synaptic plasticity Translational Medical Research
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