Identification of functionally important amino acid sequences in cobra venom factor using human C3/Cobra venom factor hybrid proteins

Cobra venom factor (CVF) is the complement-activating protein in cobra venom. CVF is a structural and functional analog of complement component C3. CVF, like C3b, forms a convertase with factor B. This bimolecular complex CVF,Bb is an enzyme that cleaves C3 and C5. However, CVF,Bb exhibits significa...

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Veröffentlicht in:	Toxicon (Oxford) 2019-09, Vol.167, p.106-116
Hauptverfasser:	Hew, Brian E., Fritzinger, David C., Pangburn, Michael K., Vogel, Carl-Wilhelm
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence C3 convertase Cobra (naja sp.) Cobra venom factor Complement Complement C3 - chemistry Complement component C3 Elapid Venoms - chemistry Humans Hybrid proteins Recombinant Fusion Proteins - chemistry Sequence Analysis, Protein Structure-Activity Relationship
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