Parahydrogen induced hyperpolarization provides a tool for NMR metabolomics at nanomolar concentrations

An NMR approach based on parahydrogen hyperpolarization is presented to detect and resolve specific classes of metabolites in complex biomixtures at down to nanomolar concentrations. We demonstrate our method on solid phase extracts of urine, by simultaneously observing hundreds of metabolites well...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2019-06, Vol.55 (5), p.7235-7238
Hauptverfasser:	Sellies, Lisanne, Reile, Indrek, Aspers, Ruud L. E. G, Feiters, Martin C, Rutjes, Floris P. J. T, Tessari, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Data processing Metabolites NMR Nuclear magnetic resonance Organic chemistry Solid phases Urine
Online-Zugang:	Volltext
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