Grass carp STK38 regulates IFN I expression by decreasing the phosphorylation level of GSK3β

As a member of NDR protein kinase family and a novel protein kinase of Hippo signal pathway, Serine/threonine kinase 38 (STK38) plays a very significant role in the innate immune. In mammals, STK38 performs its function by combining with GSK3β. Nowadays, there are few reports of STK38 in fish. In or...

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Veröffentlicht in:	Developmental and comparative immunology 2019-10, Vol.99, p.103410-103410, Article 103410
Hauptverfasser:	Xu, Kang, Xie, Xiaofen, Qi, Guoqin, Weng, Panwei, Hu, Zhizhen, Han, Kun, Yuan, Huiwen, Li, Yinping, Ran, Xiaoqin, Lin, Gang, Hu, Chengyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral agents Carp Carps - classification Carps - genetics Carps - immunology Cell Line Cell Nucleus - metabolism Ctenopharyngodon idella Cytoplasm Cytoplasm - metabolism Fish Fish Proteins - genetics Fish Proteins - metabolism Gene Expression Regulation Gene Knockdown Techniques Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism GSK3β dephosphorylation Immunity Immunity, Innate - genetics Immunoprecipitation Innate immunity Interferon Interferon Type I - genetics Kinases Localization Ndr protein Nuclei (cytology) Phosphorylation Phylogeny Poly I-C - immunology Polyinosinic:polycytidylic acid Protein Binding Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-serine/threonine kinase Proteins STK38 Transfection Type I IFN
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