Design and development of 1,3,4-oxadiazole derivatives as potential inhibitors of acetylcholinesterase to ameliorate scopolamine-induced cognitive dysfunctions

[Display omitted] •4-AP tethered 1,3,4-oxadiazole derivatives were designed and synthesized.•Compound 9 elicited significant non-competitive type of hAChE inhibition.•Compound 9 showed significant brain permeability in PAMPA-BBB assay.•Compound 9 ameliorated scopolamine- induced cognitive impairment...

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Veröffentlicht in:	Bioorganic chemistry 2019-08, Vol.89, p.103025-103025, Article 103025
Hauptverfasser:	Mishra, Puja, Sharma, Piyoosh, Tripathi, Prabhash Nath, Gupta, Sukesh Kumar, Srivastava, Pavan, Seth, Ankit, Tripathi, Avanish, Krishnamurthy, Sairam, Shrivastava, Sushant Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3,4-Oxadiazole 4-Aminopyridine Acetylcholinesterase Butyrylcholinesterase Molecular hybridization
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