The role of mitochondria-derived peptides in cardiovascular disease: Recent updates
Mitochondria-derived peptides (MDPs) are a series of peptides encoded by mitochondrial DNA, and have similar functions to mitochondria. At present there are three types of MDPs that have been found, including Humanin, MOTS-c and SHLP1-6. They are new metabolic regulators of human body, and play a cy...
Gespeichert in:
| Veröffentlicht in: | Biomedicine & pharmacotherapy 2019-09, Vol.117, p.109075-109075, Article 109075 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 109075 |
|---|---|
| container_issue | |
| container_start_page | 109075 |
| container_title | Biomedicine & pharmacotherapy |
| container_volume | 117 |
| creator | Yang, Yingxi Gao, Huijuan Zhou, Huan Liu, Qi Qi, Zhongwen Zhang, Ying Zhang, Junping |
| description | Mitochondria-derived peptides (MDPs) are a series of peptides encoded by mitochondrial DNA, and have similar functions to mitochondria. At present there are three types of MDPs that have been found, including Humanin, MOTS-c and SHLP1-6. They are new metabolic regulators of human body, and play a cytoprotective role in maintaining mitochondrial function and cell viability under pressure. Increasingly researchers have demonstrated that MDPs have proved effects on cell survival, metabolism, response to stressors, and inflammation in vivo and vitro. Recently with the advance of research, it have shown that MDPs have significant effects on the development of cardiovascular diseases (CVD). In this review, we will cover the relationships of MDPs with cardiovascular risk factors, myocardial ischemia, reperfusion injury, myocardial fibrosis, and coronary microcirculatory dysfunction, and also their possible pathogenic mechanisms. MDPs are considered to be novel biomarkers or therapeutic targets for CVD. |
| doi_str_mv | 10.1016/j.biopha.2019.109075 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2242166874</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0753332219315781</els_id><sourcerecordid>2242166874</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-450dfffeaf56b0886518238753d3b383b72d01219ca85c1af481cbd0ea6728683</originalsourceid><addsrcrecordid>eNp9kEtLxDAUhYMoOo7-A5Es3XTMo01TF4IMvmBA0HEd0uSWydA2NWkH_Pd26OjS1YXDOffc-yF0RcmCEiput4vS-W6jF4zQYpQKkmdHaEaLjCSCkPwYzUaFJ5wzdobOY9wSQjLB5Sk645TKjEs5Qx_rDeDga8C-wo3rvdn41ganEwvB7cDiDrreWYjYtdjoYJ3f6WiGWgdsXQQd4Q6_g4G2x0NndQ_xAp1Uuo5weZhz9Pn0uF6-JKu359flwyoxKZF9kmbEVlUFuspESaQUGZWMy_Fmy0sueZkzSyijhdEyM1RXqaSmtAS0yJkUks_RzbS3C_5rgNirxkUDda1b8ENUjKWMCiHzdLSmk9UEH2OASnXBNTp8K0rUHqfaqgmn2uNUE84xdn1oGMoG7F_ol99ouJ8MMP65cxBUNA5aA9YFML2y3v3f8AP51YfZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2242166874</pqid></control><display><type>article</type><title>The role of mitochondria-derived peptides in cardiovascular disease: Recent updates</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Yang, Yingxi ; Gao, Huijuan ; Zhou, Huan ; Liu, Qi ; Qi, Zhongwen ; Zhang, Ying ; Zhang, Junping</creator><creatorcontrib>Yang, Yingxi ; Gao, Huijuan ; Zhou, Huan ; Liu, Qi ; Qi, Zhongwen ; Zhang, Ying ; Zhang, Junping</creatorcontrib><description>Mitochondria-derived peptides (MDPs) are a series of peptides encoded by mitochondrial DNA, and have similar functions to mitochondria. At present there are three types of MDPs that have been found, including Humanin, MOTS-c and SHLP1-6. They are new metabolic regulators of human body, and play a cytoprotective role in maintaining mitochondrial function and cell viability under pressure. Increasingly researchers have demonstrated that MDPs have proved effects on cell survival, metabolism, response to stressors, and inflammation in vivo and vitro. Recently with the advance of research, it have shown that MDPs have significant effects on the development of cardiovascular diseases (CVD). In this review, we will cover the relationships of MDPs with cardiovascular risk factors, myocardial ischemia, reperfusion injury, myocardial fibrosis, and coronary microcirculatory dysfunction, and also their possible pathogenic mechanisms. MDPs are considered to be novel biomarkers or therapeutic targets for CVD.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2019.109075</identifier><identifier>PMID: 31185388</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Animals ; Apoptosis - drug effects ; Cardiovascular disease ; Cardiovascular Diseases - drug therapy ; Humanin ; Humans ; Mitochondria - chemistry ; Mitochondria-derived peptides ; MOTS-c ; Oxidative Stress - drug effects ; Peptides - pharmacology ; Peptides - therapeutic use ; Risk Factors</subject><ispartof>Biomedicine & pharmacotherapy, 2019-09, Vol.117, p.109075-109075, Article 109075</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier Masson SAS.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-450dfffeaf56b0886518238753d3b383b72d01219ca85c1af481cbd0ea6728683</citedby><cites>FETCH-LOGICAL-c408t-450dfffeaf56b0886518238753d3b383b72d01219ca85c1af481cbd0ea6728683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopha.2019.109075$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31185388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Yingxi</creatorcontrib><creatorcontrib>Gao, Huijuan</creatorcontrib><creatorcontrib>Zhou, Huan</creatorcontrib><creatorcontrib>Liu, Qi</creatorcontrib><creatorcontrib>Qi, Zhongwen</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Zhang, Junping</creatorcontrib><title>The role of mitochondria-derived peptides in cardiovascular disease: Recent updates</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>Mitochondria-derived peptides (MDPs) are a series of peptides encoded by mitochondrial DNA, and have similar functions to mitochondria. At present there are three types of MDPs that have been found, including Humanin, MOTS-c and SHLP1-6. They are new metabolic regulators of human body, and play a cytoprotective role in maintaining mitochondrial function and cell viability under pressure. Increasingly researchers have demonstrated that MDPs have proved effects on cell survival, metabolism, response to stressors, and inflammation in vivo and vitro. Recently with the advance of research, it have shown that MDPs have significant effects on the development of cardiovascular diseases (CVD). In this review, we will cover the relationships of MDPs with cardiovascular risk factors, myocardial ischemia, reperfusion injury, myocardial fibrosis, and coronary microcirculatory dysfunction, and also their possible pathogenic mechanisms. MDPs are considered to be novel biomarkers or therapeutic targets for CVD.</description><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - drug therapy</subject><subject>Humanin</subject><subject>Humans</subject><subject>Mitochondria - chemistry</subject><subject>Mitochondria-derived peptides</subject><subject>MOTS-c</subject><subject>Oxidative Stress - drug effects</subject><subject>Peptides - pharmacology</subject><subject>Peptides - therapeutic use</subject><subject>Risk Factors</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoOo7-A5Es3XTMo01TF4IMvmBA0HEd0uSWydA2NWkH_Pd26OjS1YXDOffc-yF0RcmCEiput4vS-W6jF4zQYpQKkmdHaEaLjCSCkPwYzUaFJ5wzdobOY9wSQjLB5Sk645TKjEs5Qx_rDeDga8C-wo3rvdn41ganEwvB7cDiDrreWYjYtdjoYJ3f6WiGWgdsXQQd4Q6_g4G2x0NndQ_xAp1Uuo5weZhz9Pn0uF6-JKu359flwyoxKZF9kmbEVlUFuspESaQUGZWMy_Fmy0sueZkzSyijhdEyM1RXqaSmtAS0yJkUks_RzbS3C_5rgNirxkUDda1b8ENUjKWMCiHzdLSmk9UEH2OASnXBNTp8K0rUHqfaqgmn2uNUE84xdn1oGMoG7F_ol99ouJ8MMP65cxBUNA5aA9YFML2y3v3f8AP51YfZ</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Yang, Yingxi</creator><creator>Gao, Huijuan</creator><creator>Zhou, Huan</creator><creator>Liu, Qi</creator><creator>Qi, Zhongwen</creator><creator>Zhang, Ying</creator><creator>Zhang, Junping</creator><general>Elsevier Masson SAS</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201909</creationdate><title>The role of mitochondria-derived peptides in cardiovascular disease: Recent updates</title><author>Yang, Yingxi ; Gao, Huijuan ; Zhou, Huan ; Liu, Qi ; Qi, Zhongwen ; Zhang, Ying ; Zhang, Junping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-450dfffeaf56b0886518238753d3b383b72d01219ca85c1af481cbd0ea6728683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - drug therapy</topic><topic>Humanin</topic><topic>Humans</topic><topic>Mitochondria - chemistry</topic><topic>Mitochondria-derived peptides</topic><topic>MOTS-c</topic><topic>Oxidative Stress - drug effects</topic><topic>Peptides - pharmacology</topic><topic>Peptides - therapeutic use</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Yingxi</creatorcontrib><creatorcontrib>Gao, Huijuan</creatorcontrib><creatorcontrib>Zhou, Huan</creatorcontrib><creatorcontrib>Liu, Qi</creatorcontrib><creatorcontrib>Qi, Zhongwen</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Zhang, Junping</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Yingxi</au><au>Gao, Huijuan</au><au>Zhou, Huan</au><au>Liu, Qi</au><au>Qi, Zhongwen</au><au>Zhang, Ying</au><au>Zhang, Junping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of mitochondria-derived peptides in cardiovascular disease: Recent updates</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2019-09</date><risdate>2019</risdate><volume>117</volume><spage>109075</spage><epage>109075</epage><pages>109075-109075</pages><artnum>109075</artnum><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>Mitochondria-derived peptides (MDPs) are a series of peptides encoded by mitochondrial DNA, and have similar functions to mitochondria. At present there are three types of MDPs that have been found, including Humanin, MOTS-c and SHLP1-6. They are new metabolic regulators of human body, and play a cytoprotective role in maintaining mitochondrial function and cell viability under pressure. Increasingly researchers have demonstrated that MDPs have proved effects on cell survival, metabolism, response to stressors, and inflammation in vivo and vitro. Recently with the advance of research, it have shown that MDPs have significant effects on the development of cardiovascular diseases (CVD). In this review, we will cover the relationships of MDPs with cardiovascular risk factors, myocardial ischemia, reperfusion injury, myocardial fibrosis, and coronary microcirculatory dysfunction, and also their possible pathogenic mechanisms. MDPs are considered to be novel biomarkers or therapeutic targets for CVD.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>31185388</pmid><doi>10.1016/j.biopha.2019.109075</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0753-3322 |
| ispartof | Biomedicine & pharmacotherapy, 2019-09, Vol.117, p.109075-109075, Article 109075 |
| issn | 0753-3322 1950-6007 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2242166874 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Apoptosis - drug effects Cardiovascular disease Cardiovascular Diseases - drug therapy Humanin Humans Mitochondria - chemistry Mitochondria-derived peptides MOTS-c Oxidative Stress - drug effects Peptides - pharmacology Peptides - therapeutic use Risk Factors |
| title | The role of mitochondria-derived peptides in cardiovascular disease: Recent updates |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T22%3A08%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20mitochondria-derived%20peptides%20in%20cardiovascular%20disease:%20Recent%20updates&rft.jtitle=Biomedicine%20&%20pharmacotherapy&rft.au=Yang,%20Yingxi&rft.date=2019-09&rft.volume=117&rft.spage=109075&rft.epage=109075&rft.pages=109075-109075&rft.artnum=109075&rft.issn=0753-3322&rft.eissn=1950-6007&rft_id=info:doi/10.1016/j.biopha.2019.109075&rft_dat=%3Cproquest_cross%3E2242166874%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2242166874&rft_id=info:pmid/31185388&rft_els_id=S0753332219315781&rfr_iscdi=true |