Increase of late sodium current contributes to enhanced susceptibility to atrial fibrillation in diabetic mice

Studies demonstrated that the incidence of atrial fibrillation is significantly increased in patients with diabetes mellitus. Increase of late sodium current (INaL) has been associated with atrial arrhythmias. However, the role of INaL in the setting of atrial fibrillation in diabetes mellitus remai...

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Veröffentlicht in:	European journal of pharmacology 2019-08, Vol.857, p.172444-172444, Article 172444
Hauptverfasser:	Jin, Xuexin, Jiang, Yuan, Xue, Genlong, Yuan, Yin, Zhu, Haixia, Zhan, Linfeng, Zhuang, Yuting, Huang, Qihe, Shi, Ling, Zhao, Yue, Li, Penghui, Sun, Yilin, Su, Wanzhen, Zhang, Yang, Yang, Baofeng, Lu, Yanjie, Wang, Zhiguo, Pan, Zhenwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential duration Action Potentials - drug effects Animals Atrial fibrillation Atrial Fibrillation - complications Atrial Fibrillation - metabolism Atrial Fibrillation - physiopathology Diabetes Mellitus, Experimental - complications Diabetic mice Electrophysiological Phenomena - drug effects Late sodium current Male Mice Mice, Inbred C57BL Pyridines - pharmacology Sodium - metabolism Sodium Channel Blockers - pharmacology Triazoles - pharmacology
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