Adsorption and insertion of polyarginine peptides into membrane pores: The trade-off between electrostatics, acid-base chemistry and pore formation energy

[Display omitted] The mechanism that arginine-rich cell penetrating peptides (ARCPPs) use to translocate lipid membranes is not entirely understood. In the present work, we develop a molecular theory that allows to investigate the adsorption and insertion of ARCPPs on membranes bearing hydrophilic p...

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Veröffentlicht in:	Journal of colloid and interface science 2019-09, Vol.552, p.701-711
Hauptverfasser:	Ramírez, Pedro G., Del Pópolo, Mario G., Vila, Jorge A., Szleifer, I., Longo, Gabriel S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Cell penetrating peptides Cell-Penetrating Peptides - chemistry Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions Lipid Bilayers - chemistry Molecular Conformation Molecular modeling Molecular Structure Particle Size Peptides - chemistry Static Electricity Surface Properties Thermodynamics
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