Sphingolipids and the unfolded protein response
The unfolded protein response (UPR) is a response by the endoplasmic reticulum to stress, classically caused by any disruption to cell homeostasis that results in an accumulation in unfolded proteins. However, there is an increasing body of research demonstrating that the UPR can also be activated b...
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| Veröffentlicht in: | Biochimica et biophysica acta. Molecular and cell biology of lipids 2019-10, Vol.1864 (10), p.1483-1494 |
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| container_issue | 10 |
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| container_title | Biochimica et biophysica acta. Molecular and cell biology of lipids |
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| creator | Bennett, Melissa K. Wallington-Beddoe, Craig T. Pitson, Stuart M. |
| description | The unfolded protein response (UPR) is a response by the endoplasmic reticulum to stress, classically caused by any disruption to cell homeostasis that results in an accumulation in unfolded proteins. However, there is an increasing body of research demonstrating that the UPR can also be activated by changes in lipid homeostasis, including changes in sphingolipid metabolism. Sphingolipids are a family of bioactive lipids with important roles in both the formation and integrity of cellular membranes, and regulation of key cellular processes, including cell proliferation and apoptosis. Bi-directional interactions between sphingolipids and the UPR have now been observed in a range of diseases, including cancer, diabetes and liver disease. Determining how these two key cellular components influence each other could play an important role in deciphering the causes of these diseases and potentially reveal new therapeutic approaches.
•The unfolded protein response is classically activated by unfolded proteins.•Changes in sphingolipid metabolism can also activate the unfolded protein response.•The unfolded protein response can also alter sphingolipid metabolism. |
| doi_str_mv | 10.1016/j.bbalip.2019.06.002 |
| format | Article |
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•The unfolded protein response is classically activated by unfolded proteins.•Changes in sphingolipid metabolism can also activate the unfolded protein response.•The unfolded protein response can also alter sphingolipid metabolism.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Cell Proliferation</subject><subject>Ceramide</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Endoplasmic reticulum stress</subject><subject>Humans</subject><subject>Liver Diseases - metabolism</subject><subject>Neoplasms - metabolism</subject><subject>Sphingolipids</subject><subject>Sphingolipids - metabolism</subject><subject>Unfolded Protein Response</subject><issn>1388-1981</issn><issn>1879-2618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KxDAURoMozjj6BiJdumnNTTppuhFk8A8GXKjrkCa3ToZOW5NW8O3N0NGlq4Rw7v2-HEIugWZAQdxss6rSjeszRqHMqMgoZUdkDrIoUyZAHsc7lzKFUsKMnIWwpRSWnC9PyYwDFILyYk5uXvuNaz-6uMjZkOjWJsMGk7Gtu8aiTXrfDejaxGPouzbgOTmpdRPw4nAuyPvD_dvqKV2_PD6v7tap4YINqWW0qgqKYOuYJLEuaGFLJoQ2khtrdOyRi5zXFnLIZR5fwWCEGWpkmvEFuZ72xgKfI4ZB7Vww2DS6xW4MirGcwbJkXEY0n1DjuxA81qr3bqf9twKq9qrUVk2q1F6VokJFVXHs6pAwVju0f0O_biJwOwEY__nl0KtgHLaxpvNoBmU793_CD1Wje1s</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Bennett, Melissa K.</creator><creator>Wallington-Beddoe, Craig T.</creator><creator>Pitson, Stuart M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201910</creationdate><title>Sphingolipids and the unfolded protein response</title><author>Bennett, Melissa K. ; Wallington-Beddoe, Craig T. ; Pitson, Stuart M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-d20bb70e1df1768ef707d9266ac83cdca3354643fd141484c831cedf12eae2a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Cell Proliferation</topic><topic>Ceramide</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Endoplasmic reticulum stress</topic><topic>Humans</topic><topic>Liver Diseases - metabolism</topic><topic>Neoplasms - metabolism</topic><topic>Sphingolipids</topic><topic>Sphingolipids - metabolism</topic><topic>Unfolded Protein Response</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bennett, Melissa K.</creatorcontrib><creatorcontrib>Wallington-Beddoe, Craig T.</creatorcontrib><creatorcontrib>Pitson, Stuart M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochimica et biophysica acta. Molecular and cell biology of lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bennett, Melissa K.</au><au>Wallington-Beddoe, Craig T.</au><au>Pitson, Stuart M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sphingolipids and the unfolded protein response</atitle><jtitle>Biochimica et biophysica acta. Molecular and cell biology of lipids</jtitle><addtitle>Biochim Biophys Acta Mol Cell Biol Lipids</addtitle><date>2019-10</date><risdate>2019</risdate><volume>1864</volume><issue>10</issue><spage>1483</spage><epage>1494</epage><pages>1483-1494</pages><issn>1388-1981</issn><eissn>1879-2618</eissn><abstract>The unfolded protein response (UPR) is a response by the endoplasmic reticulum to stress, classically caused by any disruption to cell homeostasis that results in an accumulation in unfolded proteins. However, there is an increasing body of research demonstrating that the UPR can also be activated by changes in lipid homeostasis, including changes in sphingolipid metabolism. Sphingolipids are a family of bioactive lipids with important roles in both the formation and integrity of cellular membranes, and regulation of key cellular processes, including cell proliferation and apoptosis. Bi-directional interactions between sphingolipids and the UPR have now been observed in a range of diseases, including cancer, diabetes and liver disease. Determining how these two key cellular components influence each other could play an important role in deciphering the causes of these diseases and potentially reveal new therapeutic approaches.
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| identifier | ISSN: 1388-1981 |
| ispartof | Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019-10, Vol.1864 (10), p.1483-1494 |
| issn | 1388-1981 1879-2618 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Apoptosis Cell Proliferation Ceramide Diabetes Mellitus - metabolism Endoplasmic reticulum stress Humans Liver Diseases - metabolism Neoplasms - metabolism Sphingolipids Sphingolipids - metabolism Unfolded Protein Response |
| title | Sphingolipids and the unfolded protein response |
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