Familial L723P Mutation Can Shift the Distribution between the Alternative APP Transmembrane Domain Cleavage Cascades by Local Unfolding of the Ε‑Cleavage Site Suggesting a Straightforward Mechanism of Alzheimer’s Disease Pathogenesis

Alzheimer’s disease is an age-related pathology associated with accumulation of amyloid-β peptides, products of enzymatic cleavage of amyloid-β precursor protein (APP) by secretases. Several familial mutations causing early onset of the disease have been identified in the APP transmembrane (TM) doma...

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Veröffentlicht in:	ACS chemical biology 2019-07, Vol.14 (7), p.1573-1582
Hauptverfasser:	Bocharov, Eduard V, Nadezhdin, Kirill D, Urban, Anatoly S, Volynsky, Pavel E, Pavlov, Konstantin V, Efremov, Roman G, Arseniev, Alexander S, Bocharova, Olga V
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Amino Acid Sequence Amyloid beta-Protein Precursor - chemistry Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Humans Lipid Bilayers - metabolism Molecular Dynamics Simulation Point Mutation Protein Domains Protein Unfolding Proteolysis
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