CCN3/Nephroblastoma Overexpressed Is a Functional Mediator of Prostate Cancer Bone Metastasis That Is Associated with Poor Patient Prognosis

Prostate cancer (PC) commonly metastasizes to the bone, resulting in pathologic fractures and poor prognosis. CCN3/nephroblastoma overexpressed is a secreted protein with a known role in promoting breast cancer metastasis to bone. However, in PC, CCN3 has been ascribed conflicting roles; some studie...

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Veröffentlicht in:	The American journal of pathology 2019-07, Vol.189 (7), p.1451-1461
Hauptverfasser:	Dankner, Matthew, Ouellet, Véronique, Communal, Laudine, Schmitt, Estelle, Perkins, Dru, Annis, Matthew G., Barrès, Véronique, Caron, Christine, Mes-Masson, Anne-Marie, Saad, Fred, Siegel, Peter M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Bone Neoplasms - secondary Cell Line, Tumor Gene Expression Regulation, Neoplastic Humans Kallikreins - biosynthesis Kallikreins - genetics Male Neoplasm Metastasis Neoplasm Proteins Nephroblastoma Overexpressed Protein - metabolism Prostate-Specific Antigen - biosynthesis Prostate-Specific Antigen - genetics Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Androgen - genetics Receptors, Androgen - metabolism Signal Transduction - genetics
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