Autophagy is essential for oligodendrocyte differentiation, survival, and proper myelination

Deficient myelination, the spiral wrapping of highly specialized membrane around axons, causes severe neurological disorders. Maturation of oligodendrocyte progenitor cells (OPC) to myelinating oligodendrocytes (OL), the sole providers of central nervous system (CNS) myelin, is tightly regulated and...

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Veröffentlicht in:	Glia 2019-09, Vol.67 (9), p.1745-1759
Hauptverfasser:	Bankston, Andrew N., Forston, Michael D., Howard, Russell M., Andres, Kariena R., Smith, Allison E., Ohri, Sujata Saraswat, Bates, Margaret L., Bunge, Mary B., Whittemore, Scott R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autophagy Autophagy - physiology Autophagy-Related Protein 5 - deficiency Autophagy-Related Protein 5 - genetics Axons Cell Survival - physiology Cells (biology) Cells, Cultured Central nervous system Cerebral Cortex - physiology Clonal deletion Coculture Techniques Cytoplasm development Differentiation Dorsal root ganglia Female Ganglia, Spinal - physiology Gene deletion Glial stem cells Lysosomes Male Maturation Mice, Inbred C57BL Mice, Transgenic Myelin Myelination Neurogenesis - physiology Neurological diseases oligodendrocyte Oligodendrocyte Precursor Cells - physiology Oligodendrocytes Oligodendroglia - physiology Organelles Phagocytosis Phagosomes Pharmacology Progenitor cells Rats, Sprague-Dawley Spiral wrapping Survival Tremor
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