Prevalence and related factors of sarcopenia in newly diagnosed cancer patients
Introduction Sarcopenia is defined as the loss of muscle mass and muscular functioning. Although sarcopenia prevalence is highly variable in the literature, pre-chemotherapy sarcopenia prevalence was not well studied in newly diagnosed cancer patients. In this context, the present study aims to dete...
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| Veröffentlicht in: | Supportive care in cancer 2020-02, Vol.28 (2), p.837-843 |
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| container_title | Supportive care in cancer |
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| creator | Oflazoglu, Utku Alacacioglu, Ahmet Varol, Umut Kucukzeybek, Yuksel Salman, Tarik Taskaynatan, Halil Yildiz, Yasar Ozdemir, Ozlem Tarhan, MustafaOktay |
| description | Introduction
Sarcopenia is defined as the loss of muscle mass and muscular functioning. Although sarcopenia prevalence is highly variable in the literature, pre-chemotherapy sarcopenia prevalence was not well studied in newly diagnosed cancer patients. In this context, the present study aims to determine the prevalence of sarcopenia and its related factors in this population.
Material and methods
Prospectively, newly diagnosed cancer patients were evaluated for body composition measurement and muscle strength by employing the bioelectric impedance analysis method and handgrip dynamometer tool.
Results
A total of 461 patients were included in the study. The median age of patients was 59 years (range 18–83) and 258 patients (56%) were women. Sarcopenia was present in 77 patients (16.7%) and was at significantly higher frequencies in men (
p
= 0.015), advanced age (≥ 65 years,
p
= 0.014), lower body mass index (BMI |
| doi_str_mv | 10.1007/s00520-019-04880-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2235065447</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A611053644</galeid><sourcerecordid>A611053644</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-ccf6f45a2c6fb2593112fd050151e08192b81471a34c6b7d476e6789b176e77d3</originalsourceid><addsrcrecordid>eNp9kU9rFTEUxYMo9tn6BVxIwI2baW_-zyxLqVYotAu7DpnMzSNlXvJM5in99s3z1YoikkVC8juHk3sIecfglAGYswqgOHTAhg5k30MnX5AVk0J0RojhJVnBIFknhVJH5E2t9wDMGMVfkyPBmG5gvyI3twW_uxmTR-rSRAvObsGJBueXXCrNgVZXfN5iio7GRBP-mB_oFN065dpA75q00K1bIqalnpBXwc0V3z7tx-Tu0-XXi6vu-ubzl4vz685LyZfO-6CDVI57HUauhhaIhwkUMMUQejbwsWfSMCek16OZpNGoTT-MrB2MmcQx-Xjw3Zb8bYd1sZtYPc6zS5h31XIuFGglpWnoh7_Q-7wrqaXbU5L3BtrMnql1m4aNKeSlOL83teeaMVBCS9mo039QbU24iT4nDLHd_yHgB4EvudaCwW5L3LjyYBnYfYv20KJtLdqfLdq96P1T4t24welZ8qu2BogDUNtTWmP5_aX_2D4C6xakRg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2234287043</pqid></control><display><type>article</type><title>Prevalence and related factors of sarcopenia in newly diagnosed cancer patients</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Oflazoglu, Utku ; Alacacioglu, Ahmet ; Varol, Umut ; Kucukzeybek, Yuksel ; Salman, Tarik ; Taskaynatan, Halil ; Yildiz, Yasar ; Ozdemir, Ozlem ; Tarhan, MustafaOktay</creator><creatorcontrib>Oflazoglu, Utku ; Alacacioglu, Ahmet ; Varol, Umut ; Kucukzeybek, Yuksel ; Salman, Tarik ; Taskaynatan, Halil ; Yildiz, Yasar ; Ozdemir, Ozlem ; Tarhan, MustafaOktay</creatorcontrib><description>Introduction
Sarcopenia is defined as the loss of muscle mass and muscular functioning. Although sarcopenia prevalence is highly variable in the literature, pre-chemotherapy sarcopenia prevalence was not well studied in newly diagnosed cancer patients. In this context, the present study aims to determine the prevalence of sarcopenia and its related factors in this population.
Material and methods
Prospectively, newly diagnosed cancer patients were evaluated for body composition measurement and muscle strength by employing the bioelectric impedance analysis method and handgrip dynamometer tool.
Results
A total of 461 patients were included in the study. The median age of patients was 59 years (range 18–83) and 258 patients (56%) were women. Sarcopenia was present in 77 patients (16.7%) and was at significantly higher frequencies in men (
p
= 0.015), advanced age (≥ 65 years,
p
= 0.014), lower body mass index (BMI < 25,
p
= < 0.001), and poor performance status (ECOG status > 0,
p
= 0.026). In multivariate analyses, advanced age (over 65 years), gender (men), and lower body mass index (BMI < 25) were significantly associated with sarcopenia (
p
values 0.033, < 0.001, and < 0.001, respectively).
Conclusions
Our study is the first prevalence study conducted with bioelectric impedance analysis on Turkish cancer patients and sarcopenia was detected to be notably prevalent among our patients with newly diagnosed cancer. Given the likely negative outcomes of sarcopenia reported in the literature (treatment failure, increased complications, and impaired survival), it is important to know the presence of sarcopenia before treatment and take preventive precautions.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-019-04880-4</identifier><identifier>PMID: 31161438</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Body mass index ; Cancer ; Cancer patients ; Care and treatment ; Chemotherapy ; Female ; Health risk assessment ; Humans ; Male ; Medical diagnosis ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Neoplasms - complications ; Nursing ; Nursing Research ; Oncology ; Original Article ; Pain Medicine ; Physiological aspects ; Prevalence ; Rehabilitation Medicine ; Sarcopenia ; Sarcopenia - epidemiology ; Trends</subject><ispartof>Supportive care in cancer, 2020-02, Vol.28 (2), p.837-843</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Supportive Care in Cancer is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-ccf6f45a2c6fb2593112fd050151e08192b81471a34c6b7d476e6789b176e77d3</citedby><cites>FETCH-LOGICAL-c442t-ccf6f45a2c6fb2593112fd050151e08192b81471a34c6b7d476e6789b176e77d3</cites><orcidid>0000-0002-6819-5831</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-019-04880-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-019-04880-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31161438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oflazoglu, Utku</creatorcontrib><creatorcontrib>Alacacioglu, Ahmet</creatorcontrib><creatorcontrib>Varol, Umut</creatorcontrib><creatorcontrib>Kucukzeybek, Yuksel</creatorcontrib><creatorcontrib>Salman, Tarik</creatorcontrib><creatorcontrib>Taskaynatan, Halil</creatorcontrib><creatorcontrib>Yildiz, Yasar</creatorcontrib><creatorcontrib>Ozdemir, Ozlem</creatorcontrib><creatorcontrib>Tarhan, MustafaOktay</creatorcontrib><title>Prevalence and related factors of sarcopenia in newly diagnosed cancer patients</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Introduction
Sarcopenia is defined as the loss of muscle mass and muscular functioning. Although sarcopenia prevalence is highly variable in the literature, pre-chemotherapy sarcopenia prevalence was not well studied in newly diagnosed cancer patients. In this context, the present study aims to determine the prevalence of sarcopenia and its related factors in this population.
Material and methods
Prospectively, newly diagnosed cancer patients were evaluated for body composition measurement and muscle strength by employing the bioelectric impedance analysis method and handgrip dynamometer tool.
Results
A total of 461 patients were included in the study. The median age of patients was 59 years (range 18–83) and 258 patients (56%) were women. Sarcopenia was present in 77 patients (16.7%) and was at significantly higher frequencies in men (
p
= 0.015), advanced age (≥ 65 years,
p
= 0.014), lower body mass index (BMI < 25,
p
= < 0.001), and poor performance status (ECOG status > 0,
p
= 0.026). In multivariate analyses, advanced age (over 65 years), gender (men), and lower body mass index (BMI < 25) were significantly associated with sarcopenia (
p
values 0.033, < 0.001, and < 0.001, respectively).
Conclusions
Our study is the first prevalence study conducted with bioelectric impedance analysis on Turkish cancer patients and sarcopenia was detected to be notably prevalent among our patients with newly diagnosed cancer. Given the likely negative outcomes of sarcopenia reported in the literature (treatment failure, increased complications, and impaired survival), it is important to know the presence of sarcopenia before treatment and take preventive precautions.</description><subject>Body mass index</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Neoplasms - complications</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Physiological aspects</subject><subject>Prevalence</subject><subject>Rehabilitation Medicine</subject><subject>Sarcopenia</subject><subject>Sarcopenia - epidemiology</subject><subject>Trends</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU9rFTEUxYMo9tn6BVxIwI2baW_-zyxLqVYotAu7DpnMzSNlXvJM5in99s3z1YoikkVC8juHk3sIecfglAGYswqgOHTAhg5k30MnX5AVk0J0RojhJVnBIFknhVJH5E2t9wDMGMVfkyPBmG5gvyI3twW_uxmTR-rSRAvObsGJBueXXCrNgVZXfN5iio7GRBP-mB_oFN065dpA75q00K1bIqalnpBXwc0V3z7tx-Tu0-XXi6vu-ubzl4vz685LyZfO-6CDVI57HUauhhaIhwkUMMUQejbwsWfSMCek16OZpNGoTT-MrB2MmcQx-Xjw3Zb8bYd1sZtYPc6zS5h31XIuFGglpWnoh7_Q-7wrqaXbU5L3BtrMnql1m4aNKeSlOL83teeaMVBCS9mo039QbU24iT4nDLHd_yHgB4EvudaCwW5L3LjyYBnYfYv20KJtLdqfLdq96P1T4t24welZ8qu2BogDUNtTWmP5_aX_2D4C6xakRg</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Oflazoglu, Utku</creator><creator>Alacacioglu, Ahmet</creator><creator>Varol, Umut</creator><creator>Kucukzeybek, Yuksel</creator><creator>Salman, Tarik</creator><creator>Taskaynatan, Halil</creator><creator>Yildiz, Yasar</creator><creator>Ozdemir, Ozlem</creator><creator>Tarhan, MustafaOktay</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6819-5831</orcidid></search><sort><creationdate>20200201</creationdate><title>Prevalence and related factors of sarcopenia in newly diagnosed cancer patients</title><author>Oflazoglu, Utku ; Alacacioglu, Ahmet ; Varol, Umut ; Kucukzeybek, Yuksel ; Salman, Tarik ; Taskaynatan, Halil ; Yildiz, Yasar ; Ozdemir, Ozlem ; Tarhan, MustafaOktay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-ccf6f45a2c6fb2593112fd050151e08192b81471a34c6b7d476e6789b176e77d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Body mass index</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Neoplasms - complications</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Physiological aspects</topic><topic>Prevalence</topic><topic>Rehabilitation Medicine</topic><topic>Sarcopenia</topic><topic>Sarcopenia - epidemiology</topic><topic>Trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oflazoglu, Utku</creatorcontrib><creatorcontrib>Alacacioglu, Ahmet</creatorcontrib><creatorcontrib>Varol, Umut</creatorcontrib><creatorcontrib>Kucukzeybek, Yuksel</creatorcontrib><creatorcontrib>Salman, Tarik</creatorcontrib><creatorcontrib>Taskaynatan, Halil</creatorcontrib><creatorcontrib>Yildiz, Yasar</creatorcontrib><creatorcontrib>Ozdemir, Ozlem</creatorcontrib><creatorcontrib>Tarhan, MustafaOktay</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oflazoglu, Utku</au><au>Alacacioglu, Ahmet</au><au>Varol, Umut</au><au>Kucukzeybek, Yuksel</au><au>Salman, Tarik</au><au>Taskaynatan, Halil</au><au>Yildiz, Yasar</au><au>Ozdemir, Ozlem</au><au>Tarhan, MustafaOktay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and related factors of sarcopenia in newly diagnosed cancer patients</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>28</volume><issue>2</issue><spage>837</spage><epage>843</epage><pages>837-843</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Introduction
Sarcopenia is defined as the loss of muscle mass and muscular functioning. Although sarcopenia prevalence is highly variable in the literature, pre-chemotherapy sarcopenia prevalence was not well studied in newly diagnosed cancer patients. In this context, the present study aims to determine the prevalence of sarcopenia and its related factors in this population.
Material and methods
Prospectively, newly diagnosed cancer patients were evaluated for body composition measurement and muscle strength by employing the bioelectric impedance analysis method and handgrip dynamometer tool.
Results
A total of 461 patients were included in the study. The median age of patients was 59 years (range 18–83) and 258 patients (56%) were women. Sarcopenia was present in 77 patients (16.7%) and was at significantly higher frequencies in men (
p
= 0.015), advanced age (≥ 65 years,
p
= 0.014), lower body mass index (BMI < 25,
p
= < 0.001), and poor performance status (ECOG status > 0,
p
= 0.026). In multivariate analyses, advanced age (over 65 years), gender (men), and lower body mass index (BMI < 25) were significantly associated with sarcopenia (
p
values 0.033, < 0.001, and < 0.001, respectively).
Conclusions
Our study is the first prevalence study conducted with bioelectric impedance analysis on Turkish cancer patients and sarcopenia was detected to be notably prevalent among our patients with newly diagnosed cancer. Given the likely negative outcomes of sarcopenia reported in the literature (treatment failure, increased complications, and impaired survival), it is important to know the presence of sarcopenia before treatment and take preventive precautions.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31161438</pmid><doi>10.1007/s00520-019-04880-4</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6819-5831</orcidid></addata></record> |
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| subjects | Body mass index Cancer Cancer patients Care and treatment Chemotherapy Female Health risk assessment Humans Male Medical diagnosis Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Neoplasms - complications Nursing Nursing Research Oncology Original Article Pain Medicine Physiological aspects Prevalence Rehabilitation Medicine Sarcopenia Sarcopenia - epidemiology Trends |
| title | Prevalence and related factors of sarcopenia in newly diagnosed cancer patients |
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