Comparison of phosphodiesterase 10A and dopamine transporter levels as markers of disease burden in early Parkinson's disease

ABSTRACT Background Recent work has shown loss of phosphodiesterase 10A levels in middle‐stage and advanced treated patients with PD, which was associated with motor symptom severity. Objectives To assess phosphodiesterase 10A levels in early PD and compare with loss of dopamine transporter as marke...

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Veröffentlicht in:	Movement disorders 2019-10, Vol.34 (10), p.1505-1515
Hauptverfasser:	Pagano, Gennaro, Niccolini, Flavia, Wilson, Heather, Yousaf, Tayyabah, Khan, Naheed L., Martino, Davide, Plisson, Christophe, Gunn, Roger N., Rabiner, Eugenii A., Piccini, Paola, Foltynie, Thomas, Politis, Marios
Format:	Artikel
Sprache:	eng
Schlagworte:	biomarkers DAT Dihydroxyphenylalanine Dopamine Dopamine transporter Levodopa Magnetic resonance imaging Movement disorders Neurodegenerative diseases Parkinson's disease PDE10A PET Phosphodiesterase Putamen
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