Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

The immunomodulatory drugs (IMiDs) thalidomide and its analogs, lenalidomide and pomalidomide, all FDA approved drugs for the treatment of multiple myeloma, induce ubiquitination and degradation of the lymphoid transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) via the cereblon (CRBN) E3 ubiqui...

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Veröffentlicht in:	Journal of visualized experiments 2019-05 (147)
Hauptverfasser:	Lindner, Stefanie, Steinebach, Christian, Kehm, Hannes, Mangold, Martin, Gütschow, Michael, Krönke, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Carbon-13 Magnetic Resonance Spectroscopy Cell Line, Tumor Cell Survival - drug effects Humans Leupeptins - pharmacology Multiple Myeloma - pathology Protein Multimerization Proteolysis - drug effects Proton Magnetic Resonance Spectroscopy Thalidomide - analogs & derivatives Thalidomide - pharmacology Ubiquitin-Protein Ligases - metabolism
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