Myocardial Stretch Post-atrial Contraction in Healthy Volunteers and Hypertrophic Cardiomyopathy Patients
In cardiac high-frame-rate color tissue Doppler imaging (TDI), a wave-like pattern travels over the interventricular septum (IVS) after atrial contraction. The propagation velocity of this myocardial stretch post-atrial contraction (MSPa) was proposed as a measure of left ventricular stiffness. The...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2019-08, Vol.45 (8), p.1987-1998 |
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| container_end_page | 1998 |
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| container_issue | 8 |
| container_start_page | 1987 |
| container_title | Ultrasound in medicine & biology |
| container_volume | 45 |
| creator | Strachinaru, Mihai Geleijnse, Marcel L. de Jong, Nico van den Bosch, Annemien Michels, Michelle Schinkel, Arend F.L. van der Steen, Antonius F.W. Bosch, Johan G. Vos, Hendrik J. |
| description | In cardiac high-frame-rate color tissue Doppler imaging (TDI), a wave-like pattern travels over the interventricular septum (IVS) after atrial contraction. The propagation velocity of this myocardial stretch post-atrial contraction (MSPa) was proposed as a measure of left ventricular stiffness. The aim of our study was to investigate the MSPa in patients with hypertrophic cardiomyopathy (HCM) compared with healthy volunteers. Forty-two healthy volunteers and 33 HCM patients underwent high-frame-rate (>500 Hz) TDI apical echocardiography. MSPa was visible in TDI, M-mode and speckle tracking. When assuming a wave propagating with constant velocity, MSPa in healthy volunteers (1.6 ± 0.3 m/s) did not differ from that in HCM patients (1.8 ± 0.8 m/s, p = 0.14). Yet, in 42% of patients with HCM, the MSPa had a non-constant velocity over the wall: in the basal IVS, the velocity was lower (1.4 ± 0.5 m/s), and in the mid-IVS, much higher (6.1 ± 3.4 m/s, p < 0.0001), and this effect was related to the septal thickness. The reason is hypothesized to be the reaching of maximal longitudinal myocardial distension in HCM patients. |
| doi_str_mv | 10.1016/j.ultrasmedbio.2019.04.031 |
| format | Article |
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The propagation velocity of this myocardial stretch post-atrial contraction (MSPa) was proposed as a measure of left ventricular stiffness. The aim of our study was to investigate the MSPa in patients with hypertrophic cardiomyopathy (HCM) compared with healthy volunteers. Forty-two healthy volunteers and 33 HCM patients underwent high-frame-rate (>500 Hz) TDI apical echocardiography. MSPa was visible in TDI, M-mode and speckle tracking. When assuming a wave propagating with constant velocity, MSPa in healthy volunteers (1.6 ± 0.3 m/s) did not differ from that in HCM patients (1.8 ± 0.8 m/s, p = 0.14). Yet, in 42% of patients with HCM, the MSPa had a non-constant velocity over the wall: in the basal IVS, the velocity was lower (1.4 ± 0.5 m/s), and in the mid-IVS, much higher (6.1 ± 3.4 m/s, p < 0.0001), and this effect was related to the septal thickness. The reason is hypothesized to be the reaching of maximal longitudinal myocardial distension in HCM patients.</description><identifier>ISSN: 0301-5629</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/j.ultrasmedbio.2019.04.031</identifier><identifier>PMID: 31155404</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Atrial contraction ; Cardiomyopathy, Hypertrophic - diagnostic imaging ; Cardiomyopathy, Hypertrophic - physiopathology ; Echocardiography - methods ; Female ; Healthy Volunteers ; High-frame-rate tissue Doppler ; Humans ; Male ; Middle Aged ; Myocardial Contraction - physiology ; Myocardial stretch ; Prospective Studies ; Stiffness ; Young Adult</subject><ispartof>Ultrasound in medicine & biology, 2019-08, Vol.45 (8), p.1987-1998</ispartof><rights>2019 The Authors</rights><rights>Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-a8e1e7560b6d832cb098c661efe4a4391a19d62113d2e0e642dc7ea91f8a82be3</citedby><cites>FETCH-LOGICAL-c498t-a8e1e7560b6d832cb098c661efe4a4391a19d62113d2e0e642dc7ea91f8a82be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0301562919301899$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31155404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strachinaru, Mihai</creatorcontrib><creatorcontrib>Geleijnse, Marcel L.</creatorcontrib><creatorcontrib>de Jong, Nico</creatorcontrib><creatorcontrib>van den Bosch, Annemien</creatorcontrib><creatorcontrib>Michels, Michelle</creatorcontrib><creatorcontrib>Schinkel, Arend F.L.</creatorcontrib><creatorcontrib>van der Steen, Antonius F.W.</creatorcontrib><creatorcontrib>Bosch, Johan G.</creatorcontrib><creatorcontrib>Vos, Hendrik J.</creatorcontrib><title>Myocardial Stretch Post-atrial Contraction in Healthy Volunteers and Hypertrophic Cardiomyopathy Patients</title><title>Ultrasound in medicine & biology</title><addtitle>Ultrasound Med Biol</addtitle><description>In cardiac high-frame-rate color tissue Doppler imaging (TDI), a wave-like pattern travels over the interventricular septum (IVS) after atrial contraction. The propagation velocity of this myocardial stretch post-atrial contraction (MSPa) was proposed as a measure of left ventricular stiffness. The aim of our study was to investigate the MSPa in patients with hypertrophic cardiomyopathy (HCM) compared with healthy volunteers. Forty-two healthy volunteers and 33 HCM patients underwent high-frame-rate (>500 Hz) TDI apical echocardiography. MSPa was visible in TDI, M-mode and speckle tracking. When assuming a wave propagating with constant velocity, MSPa in healthy volunteers (1.6 ± 0.3 m/s) did not differ from that in HCM patients (1.8 ± 0.8 m/s, p = 0.14). Yet, in 42% of patients with HCM, the MSPa had a non-constant velocity over the wall: in the basal IVS, the velocity was lower (1.4 ± 0.5 m/s), and in the mid-IVS, much higher (6.1 ± 3.4 m/s, p < 0.0001), and this effect was related to the septal thickness. The reason is hypothesized to be the reaching of maximal longitudinal myocardial distension in HCM patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Atrial contraction</subject><subject>Cardiomyopathy, Hypertrophic - diagnostic imaging</subject><subject>Cardiomyopathy, Hypertrophic - physiopathology</subject><subject>Echocardiography - methods</subject><subject>Female</subject><subject>Healthy Volunteers</subject><subject>High-frame-rate tissue Doppler</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Contraction - physiology</subject><subject>Myocardial stretch</subject><subject>Prospective Studies</subject><subject>Stiffness</subject><subject>Young Adult</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE2LFDEQhoMo7rj6F6Tx5KV7U0km3fEm48csrLjgB95COqlhMvR02iQt9L83zazi0VNB1VP1Ug8hr4A2QEHenJp5yNGkM7reh4ZRUA0VDeXwiGyga1XNFPx4TDaUU6i3kqkr8iylE6W0lbx9Sq44wHYrqNgQ_2kJ1kTnzVB9yRGzPVb3IeXa5Lj2dmEsUTb7MFZ-rPZohnxcqu9hmMeMGFNlRlftlwljjmE6elvt1nPhvITJrOi9yR7HnJ6TJwczJHzxUK_Jtw_vv-729d3nj7e7t3e1FaoruR0CtltJe-k6zmxPVWelBDygMIIrMKCcZADcMaQoBXO2RaPg0JmO9civyevL3SmGnzOmrM8-WRwGM2KYk2aMC9EJKaCgby6ojSGliAc9RX82cdFA9apan_S_qvWqWlOhi-qy_PIhZ-7L-O_qH7cFeHcBsHz7y2PUyRYTFp2PaLN2wf9Pzm_y45ls</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Strachinaru, Mihai</creator><creator>Geleijnse, Marcel L.</creator><creator>de Jong, Nico</creator><creator>van den Bosch, Annemien</creator><creator>Michels, Michelle</creator><creator>Schinkel, Arend F.L.</creator><creator>van der Steen, Antonius F.W.</creator><creator>Bosch, Johan G.</creator><creator>Vos, Hendrik J.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201908</creationdate><title>Myocardial Stretch Post-atrial Contraction in Healthy Volunteers and Hypertrophic Cardiomyopathy Patients</title><author>Strachinaru, Mihai ; Geleijnse, Marcel L. ; de Jong, Nico ; van den Bosch, Annemien ; Michels, Michelle ; Schinkel, Arend F.L. ; van der Steen, Antonius F.W. ; Bosch, Johan G. ; Vos, Hendrik J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-a8e1e7560b6d832cb098c661efe4a4391a19d62113d2e0e642dc7ea91f8a82be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Atrial contraction</topic><topic>Cardiomyopathy, Hypertrophic - diagnostic imaging</topic><topic>Cardiomyopathy, Hypertrophic - physiopathology</topic><topic>Echocardiography - methods</topic><topic>Female</topic><topic>Healthy Volunteers</topic><topic>High-frame-rate tissue Doppler</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Contraction - physiology</topic><topic>Myocardial stretch</topic><topic>Prospective Studies</topic><topic>Stiffness</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strachinaru, Mihai</creatorcontrib><creatorcontrib>Geleijnse, Marcel L.</creatorcontrib><creatorcontrib>de Jong, Nico</creatorcontrib><creatorcontrib>van den Bosch, Annemien</creatorcontrib><creatorcontrib>Michels, Michelle</creatorcontrib><creatorcontrib>Schinkel, Arend F.L.</creatorcontrib><creatorcontrib>van der Steen, Antonius F.W.</creatorcontrib><creatorcontrib>Bosch, Johan G.</creatorcontrib><creatorcontrib>Vos, Hendrik J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strachinaru, Mihai</au><au>Geleijnse, Marcel L.</au><au>de Jong, Nico</au><au>van den Bosch, Annemien</au><au>Michels, Michelle</au><au>Schinkel, Arend F.L.</au><au>van der Steen, Antonius F.W.</au><au>Bosch, Johan G.</au><au>Vos, Hendrik J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial Stretch Post-atrial Contraction in Healthy Volunteers and Hypertrophic Cardiomyopathy Patients</atitle><jtitle>Ultrasound in medicine & biology</jtitle><addtitle>Ultrasound Med Biol</addtitle><date>2019-08</date><risdate>2019</risdate><volume>45</volume><issue>8</issue><spage>1987</spage><epage>1998</epage><pages>1987-1998</pages><issn>0301-5629</issn><eissn>1879-291X</eissn><abstract>In cardiac high-frame-rate color tissue Doppler imaging (TDI), a wave-like pattern travels over the interventricular septum (IVS) after atrial contraction. The propagation velocity of this myocardial stretch post-atrial contraction (MSPa) was proposed as a measure of left ventricular stiffness. The aim of our study was to investigate the MSPa in patients with hypertrophic cardiomyopathy (HCM) compared with healthy volunteers. Forty-two healthy volunteers and 33 HCM patients underwent high-frame-rate (>500 Hz) TDI apical echocardiography. MSPa was visible in TDI, M-mode and speckle tracking. When assuming a wave propagating with constant velocity, MSPa in healthy volunteers (1.6 ± 0.3 m/s) did not differ from that in HCM patients (1.8 ± 0.8 m/s, p = 0.14). Yet, in 42% of patients with HCM, the MSPa had a non-constant velocity over the wall: in the basal IVS, the velocity was lower (1.4 ± 0.5 m/s), and in the mid-IVS, much higher (6.1 ± 3.4 m/s, p < 0.0001), and this effect was related to the septal thickness. 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| subjects | Adolescent Adult Aged Atrial contraction Cardiomyopathy, Hypertrophic - diagnostic imaging Cardiomyopathy, Hypertrophic - physiopathology Echocardiography - methods Female Healthy Volunteers High-frame-rate tissue Doppler Humans Male Middle Aged Myocardial Contraction - physiology Myocardial stretch Prospective Studies Stiffness Young Adult |
| title | Myocardial Stretch Post-atrial Contraction in Healthy Volunteers and Hypertrophic Cardiomyopathy Patients |
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