Hepatotoxicity of tricyclazole in zebrafish (Danio rerio)
Tricyclazole is widely used in agriculture as a pesticide, but its toxicity in vertebrates is currently poorly evaluated. In this study, we used zebrafish to assess the toxicity of tricyclazole. We found that tricyclazole induces liver damage, or hepatotoxicity, in zebrafish, during both development...
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| Veröffentlicht in: | Chemosphere (Oxford) 2019-10, Vol.232, p.171-179 |
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| creator | Qiu, Lingyu Jia, Kun Huang, Lirong Liao, Xinjun Guo, Xinchun Lu, Huiqiang |
| description | Tricyclazole is widely used in agriculture as a pesticide, but its toxicity in vertebrates is currently poorly evaluated. In this study, we used zebrafish to assess the toxicity of tricyclazole. We found that tricyclazole induces liver damage, or hepatotoxicity, in zebrafish, during both development and adulthood. In embryos, we found that tricyclazole affected the liver development rather than other endodermal tissues such as gut and pancreas. In both embryos and adult zebrafish livers, tricyclazole disrupted the relationship between oxidant and antioxidant system and resulted in reactive oxygen species (ROS) overload. Meanwhile, it triggered hepatocyte apoptosis and disturbed carbohydrate/lipid metabolism and energy demand systems. These results suggested that tricyclazole could cause severe consequences for vertebrate hepatic development and function.
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•Tricyclazole induce hepatotoxicity in zebrafish.•Tricyclazole affected the liver development in zebrafish embryos.•Tricyclazole induced ROS and apoptosis in zebrafish liver.•Tricyclazole induced metabolism disturbance in zebrafish liver. |
| doi_str_mv | 10.1016/j.chemosphere.2019.05.159 |
| format | Article |
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•Tricyclazole induce hepatotoxicity in zebrafish.•Tricyclazole affected the liver development in zebrafish embryos.•Tricyclazole induced ROS and apoptosis in zebrafish liver.•Tricyclazole induced metabolism disturbance in zebrafish liver.</description><identifier>ISSN: 0045-6535</identifier><identifier>EISSN: 1879-1298</identifier><identifier>DOI: 10.1016/j.chemosphere.2019.05.159</identifier><identifier>PMID: 31154177</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Antioxidants - metabolism ; Apoptosis ; Chemical and Drug Induced Liver Injury ; Hepatotoxicity ; Metabolism disorder ; Oxidative Stress ; Reactive Oxygen Species - metabolism ; Thiazoles - toxicity ; Tricyclazole ; Water Pollutants, Chemical - toxicity ; Zebrafish ; Zebrafish - metabolism</subject><ispartof>Chemosphere (Oxford), 2019-10, Vol.232, p.171-179</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-aca1d851bf5ff604ccda54b32e26e45a4fd5ad84c9551f7a8e0822fe237f48593</citedby><cites>FETCH-LOGICAL-c377t-aca1d851bf5ff604ccda54b32e26e45a4fd5ad84c9551f7a8e0822fe237f48593</cites><orcidid>0000-0002-3987-6742</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0045653519310719$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31154177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qiu, Lingyu</creatorcontrib><creatorcontrib>Jia, Kun</creatorcontrib><creatorcontrib>Huang, Lirong</creatorcontrib><creatorcontrib>Liao, Xinjun</creatorcontrib><creatorcontrib>Guo, Xinchun</creatorcontrib><creatorcontrib>Lu, Huiqiang</creatorcontrib><title>Hepatotoxicity of tricyclazole in zebrafish (Danio rerio)</title><title>Chemosphere (Oxford)</title><addtitle>Chemosphere</addtitle><description>Tricyclazole is widely used in agriculture as a pesticide, but its toxicity in vertebrates is currently poorly evaluated. In this study, we used zebrafish to assess the toxicity of tricyclazole. We found that tricyclazole induces liver damage, or hepatotoxicity, in zebrafish, during both development and adulthood. In embryos, we found that tricyclazole affected the liver development rather than other endodermal tissues such as gut and pancreas. In both embryos and adult zebrafish livers, tricyclazole disrupted the relationship between oxidant and antioxidant system and resulted in reactive oxygen species (ROS) overload. Meanwhile, it triggered hepatocyte apoptosis and disturbed carbohydrate/lipid metabolism and energy demand systems. These results suggested that tricyclazole could cause severe consequences for vertebrate hepatic development and function.
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•Tricyclazole induce hepatotoxicity in zebrafish.•Tricyclazole affected the liver development in zebrafish embryos.•Tricyclazole induced ROS and apoptosis in zebrafish liver.•Tricyclazole induced metabolism disturbance in zebrafish liver.</description><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Apoptosis</subject><subject>Chemical and Drug Induced Liver Injury</subject><subject>Hepatotoxicity</subject><subject>Metabolism disorder</subject><subject>Oxidative Stress</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Thiazoles - toxicity</subject><subject>Tricyclazole</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Zebrafish</subject><subject>Zebrafish - metabolism</subject><issn>0045-6535</issn><issn>1879-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkD1PwzAURS0EoqXwF1DYypBgO3Ycj6h8SpVYYLYc51l1lcTFThHtryelBTEyveXce_UOQlcEZwST4maZmQW0Pq4WECCjmMgM84xweYTGpBQyJVSWx2iMMeNpwXM-QmcxLjEewlyeolFOCGdEiDGST7DSve_9pzOu3yTeJn1wZmMavfUNJK5LtlAFbV1cJNM73TmfBAjOX5-jE6ubCBeHO0FvD_evs6d0_vL4PLudpyYXok-10aQuOakst7bAzJhac1blFGgBjGtma67rkhnJObFCl4BLSi3QXFhWcplP0HTfuwr-fQ2xV62LBppGd-DXUVGaM1bmEosBlXvUBB9jAKtWwbU6bBTBamdOLdUfc2pnTmGuyPfM5WFmXbVQ_yZ_VA3AbA_A8OyHg6CicdAZqF0A06vau3_MfAFIxIWp</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Qiu, Lingyu</creator><creator>Jia, Kun</creator><creator>Huang, Lirong</creator><creator>Liao, Xinjun</creator><creator>Guo, Xinchun</creator><creator>Lu, Huiqiang</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3987-6742</orcidid></search><sort><creationdate>201910</creationdate><title>Hepatotoxicity of tricyclazole in zebrafish (Danio rerio)</title><author>Qiu, Lingyu ; Jia, Kun ; Huang, Lirong ; Liao, Xinjun ; Guo, Xinchun ; Lu, Huiqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-aca1d851bf5ff604ccda54b32e26e45a4fd5ad84c9551f7a8e0822fe237f48593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Apoptosis</topic><topic>Chemical and Drug Induced Liver Injury</topic><topic>Hepatotoxicity</topic><topic>Metabolism disorder</topic><topic>Oxidative Stress</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Thiazoles - toxicity</topic><topic>Tricyclazole</topic><topic>Water Pollutants, Chemical - toxicity</topic><topic>Zebrafish</topic><topic>Zebrafish - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qiu, Lingyu</creatorcontrib><creatorcontrib>Jia, Kun</creatorcontrib><creatorcontrib>Huang, Lirong</creatorcontrib><creatorcontrib>Liao, Xinjun</creatorcontrib><creatorcontrib>Guo, Xinchun</creatorcontrib><creatorcontrib>Lu, Huiqiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemosphere (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qiu, Lingyu</au><au>Jia, Kun</au><au>Huang, Lirong</au><au>Liao, Xinjun</au><au>Guo, Xinchun</au><au>Lu, Huiqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatotoxicity of tricyclazole in zebrafish (Danio rerio)</atitle><jtitle>Chemosphere (Oxford)</jtitle><addtitle>Chemosphere</addtitle><date>2019-10</date><risdate>2019</risdate><volume>232</volume><spage>171</spage><epage>179</epage><pages>171-179</pages><issn>0045-6535</issn><eissn>1879-1298</eissn><abstract>Tricyclazole is widely used in agriculture as a pesticide, but its toxicity in vertebrates is currently poorly evaluated. In this study, we used zebrafish to assess the toxicity of tricyclazole. We found that tricyclazole induces liver damage, or hepatotoxicity, in zebrafish, during both development and adulthood. In embryos, we found that tricyclazole affected the liver development rather than other endodermal tissues such as gut and pancreas. In both embryos and adult zebrafish livers, tricyclazole disrupted the relationship between oxidant and antioxidant system and resulted in reactive oxygen species (ROS) overload. Meanwhile, it triggered hepatocyte apoptosis and disturbed carbohydrate/lipid metabolism and energy demand systems. These results suggested that tricyclazole could cause severe consequences for vertebrate hepatic development and function.
[Display omitted]
•Tricyclazole induce hepatotoxicity in zebrafish.•Tricyclazole affected the liver development in zebrafish embryos.•Tricyclazole induced ROS and apoptosis in zebrafish liver.•Tricyclazole induced metabolism disturbance in zebrafish liver.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31154177</pmid><doi>10.1016/j.chemosphere.2019.05.159</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3987-6742</orcidid></addata></record> |
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| ispartof | Chemosphere (Oxford), 2019-10, Vol.232, p.171-179 |
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| subjects | Animals Antioxidants - metabolism Apoptosis Chemical and Drug Induced Liver Injury Hepatotoxicity Metabolism disorder Oxidative Stress Reactive Oxygen Species - metabolism Thiazoles - toxicity Tricyclazole Water Pollutants, Chemical - toxicity Zebrafish Zebrafish - metabolism |
| title | Hepatotoxicity of tricyclazole in zebrafish (Danio rerio) |
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