Endoplasmic reticulum stress-induced iRhom2 up-regulation promotes macrophage-regulated cardiac inflammation and lipid deposition in high fat diet (HFD)-challenged mice: Intervention of fisetin and metformin

Endoplasmic reticulum stress (ERS) has been implicated in obesity-associated cardiac remodeling and dysfunction. Inactive rhomboid protein 2 (iRhom2), also known as Rhbdf2, is an inactive member of the rhomboid intramembrane proteinase family, playing an essential role in regulating inflammation. Ne...

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Veröffentlicht in:	Free radical biology & medicine 2019-09, Vol.141, p.67-83
Hauptverfasser:	Ge, Chen-Xu, Xu, Min-Xuan, Qin, Yu-Ting, Gu, Ting-Ting, Lou, De-Shuai, Li, Qiang, Hu, Lin-Feng, Wang, Bo-Chu, Tan, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiomyopathy Inflammation Lipid deposition Obesity ROS/ERS/iRhom2
Online-Zugang:	Volltext
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