Prevalence and determinants of vitamin D deficiency in infants and toddlers in the Netherlands: a pilot study
Background Little is known of the vitamin D status of young infants and toddlers and its determinants in West Europe. The prevalence and determinants of vitamin D deficiency of children aged 6–48 months in the centre of the Netherlands (52°N) is investigated. Methods In a cross-sectional population...
Gespeichert in:
Veröffentlicht in: | Annals of clinical biochemistry 2019-09, Vol.56 (5), p.613-618 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 618 |
---|---|
container_issue | 5 |
container_start_page | 613 |
container_title | Annals of clinical biochemistry |
container_volume | 56 |
creator | Hoevenaar-Blom, Marieke P Wielders, Jos PM Groeneveld, Henk de Leeuw, Elly Schmits, Ruben JH Pepermans, Carolien Pasker-de Jong, Pieternel CM Hogeman, Paul HG |
description | Background
Little is known of the vitamin D status of young infants and toddlers and its determinants in West Europe. The prevalence and determinants of vitamin D deficiency of children aged 6–48 months in the centre of the Netherlands (52°N) is investigated.
Methods
In a cross-sectional population study, randomly recruited infants and toddlers (n = 150) were studied using an online questionnaire and a physical examination either in late summer (n = 52) or in late winter (n = 98). Vitamin D analysis was performed by capillary blood sampling using dried bloodspots plus LC-MS/MS.
Results
In late winter, 32% of the children were vitamin D deficient ( |
doi_str_mv | 10.1177/0004563219857772 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2234483051</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0004563219857772</sage_id><sourcerecordid>2234483051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-490e730b9b498246fdc707a784e69437463cba945b34c61e6d351a5c238576663</originalsourceid><addsrcrecordid>eNp1kDtPwzAUhS0EoqWwMyGPLAE7fiVsqDylChhgjhznBlzlUWynUv89Di0MSCy2rs93jq4PQqeUXFCq1CUhhAvJUppnQimV7qEpVSJLKCF0H01HORn1CTryfhnHVBFyiCaMUsEzIqaofXGw1g10BrDuKlxBANfaTnfB477Gaxt0HPFNVGprbAQ3OM62q7-R0RP6qmrA-fE9fAB-gni6Jkr-Cmu8sk0fsA9DtTlGB7VuPJzs7hl6u7t9nT8ki-f7x_n1IjGMqZDwnIBipMxLnmcpl3VlFFFaZRxkzpnikplS51yUjBtJQVZMUC1MymINUko2Q-fb3JXrPwfwoWitN9DEnaAffJGmjPOMEUEjSraocb33Dupi5Wyr3aagpBhLLv6WHC1nu_ShbKH6Nfy0GoFkC3j9DsWyH1wXf_t_4BetJ4MN</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2234483051</pqid></control><display><type>article</type><title>Prevalence and determinants of vitamin D deficiency in infants and toddlers in the Netherlands: a pilot study</title><source>MEDLINE</source><source>SAGE Complete</source><creator>Hoevenaar-Blom, Marieke P ; Wielders, Jos PM ; Groeneveld, Henk ; de Leeuw, Elly ; Schmits, Ruben JH ; Pepermans, Carolien ; Pasker-de Jong, Pieternel CM ; Hogeman, Paul HG</creator><creatorcontrib>Hoevenaar-Blom, Marieke P ; Wielders, Jos PM ; Groeneveld, Henk ; de Leeuw, Elly ; Schmits, Ruben JH ; Pepermans, Carolien ; Pasker-de Jong, Pieternel CM ; Hogeman, Paul HG</creatorcontrib><description>Background
Little is known of the vitamin D status of young infants and toddlers and its determinants in West Europe. The prevalence and determinants of vitamin D deficiency of children aged 6–48 months in the centre of the Netherlands (52°N) is investigated.
Methods
In a cross-sectional population study, randomly recruited infants and toddlers (n = 150) were studied using an online questionnaire and a physical examination either in late summer (n = 52) or in late winter (n = 98). Vitamin D analysis was performed by capillary blood sampling using dried bloodspots plus LC-MS/MS.
Results
In late winter, 32% of the children were vitamin D deficient (<50 nmol/L 25OH vitamin D3) with 5% severely deficient (<25 nmol/L). In late summer, 2% were deficient. The odds of vitamin D deficiency were higher in children aged 24–48 months, for those not using formula milk and those not adhering to the supplementation guidelines.
Conclusion
One-third of Dutch infants and toddlers were found to be vitamin D deficient in late winter. Suggested strategies for raising the vitamin D status may include improving the adherence to supplementation, a sensible sun exposure or the use of fortified foods. Special attention is needed for the children aged 24–48 months.</description><identifier>ISSN: 0004-5632</identifier><identifier>EISSN: 1758-1001</identifier><identifier>DOI: 10.1177/0004563219857772</identifier><identifier>PMID: 31154805</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Child, Preschool ; Dietary Supplements ; Female ; Humans ; Infant ; Male ; Netherlands ; Pilot Projects ; Prevalence ; Vitamin D - blood ; Vitamin D Deficiency - epidemiology</subject><ispartof>Annals of clinical biochemistry, 2019-09, Vol.56 (5), p.613-618</ispartof><rights>The Author(s) 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-490e730b9b498246fdc707a784e69437463cba945b34c61e6d351a5c238576663</citedby><cites>FETCH-LOGICAL-c337t-490e730b9b498246fdc707a784e69437463cba945b34c61e6d351a5c238576663</cites><orcidid>0000-0002-3155-6373</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0004563219857772$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0004563219857772$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31154805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoevenaar-Blom, Marieke P</creatorcontrib><creatorcontrib>Wielders, Jos PM</creatorcontrib><creatorcontrib>Groeneveld, Henk</creatorcontrib><creatorcontrib>de Leeuw, Elly</creatorcontrib><creatorcontrib>Schmits, Ruben JH</creatorcontrib><creatorcontrib>Pepermans, Carolien</creatorcontrib><creatorcontrib>Pasker-de Jong, Pieternel CM</creatorcontrib><creatorcontrib>Hogeman, Paul HG</creatorcontrib><title>Prevalence and determinants of vitamin D deficiency in infants and toddlers in the Netherlands: a pilot study</title><title>Annals of clinical biochemistry</title><addtitle>Ann Clin Biochem</addtitle><description>Background
Little is known of the vitamin D status of young infants and toddlers and its determinants in West Europe. The prevalence and determinants of vitamin D deficiency of children aged 6–48 months in the centre of the Netherlands (52°N) is investigated.
Methods
In a cross-sectional population study, randomly recruited infants and toddlers (n = 150) were studied using an online questionnaire and a physical examination either in late summer (n = 52) or in late winter (n = 98). Vitamin D analysis was performed by capillary blood sampling using dried bloodspots plus LC-MS/MS.
Results
In late winter, 32% of the children were vitamin D deficient (<50 nmol/L 25OH vitamin D3) with 5% severely deficient (<25 nmol/L). In late summer, 2% were deficient. The odds of vitamin D deficiency were higher in children aged 24–48 months, for those not using formula milk and those not adhering to the supplementation guidelines.
Conclusion
One-third of Dutch infants and toddlers were found to be vitamin D deficient in late winter. Suggested strategies for raising the vitamin D status may include improving the adherence to supplementation, a sensible sun exposure or the use of fortified foods. Special attention is needed for the children aged 24–48 months.</description><subject>Child, Preschool</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Netherlands</subject><subject>Pilot Projects</subject><subject>Prevalence</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - epidemiology</subject><issn>0004-5632</issn><issn>1758-1001</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAUhS0EoqWwMyGPLAE7fiVsqDylChhgjhznBlzlUWynUv89Di0MSCy2rs93jq4PQqeUXFCq1CUhhAvJUppnQimV7qEpVSJLKCF0H01HORn1CTryfhnHVBFyiCaMUsEzIqaofXGw1g10BrDuKlxBANfaTnfB477Gaxt0HPFNVGprbAQ3OM62q7-R0RP6qmrA-fE9fAB-gni6Jkr-Cmu8sk0fsA9DtTlGB7VuPJzs7hl6u7t9nT8ki-f7x_n1IjGMqZDwnIBipMxLnmcpl3VlFFFaZRxkzpnikplS51yUjBtJQVZMUC1MymINUko2Q-fb3JXrPwfwoWitN9DEnaAffJGmjPOMEUEjSraocb33Dupi5Wyr3aagpBhLLv6WHC1nu_ShbKH6Nfy0GoFkC3j9DsWyH1wXf_t_4BetJ4MN</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Hoevenaar-Blom, Marieke P</creator><creator>Wielders, Jos PM</creator><creator>Groeneveld, Henk</creator><creator>de Leeuw, Elly</creator><creator>Schmits, Ruben JH</creator><creator>Pepermans, Carolien</creator><creator>Pasker-de Jong, Pieternel CM</creator><creator>Hogeman, Paul HG</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3155-6373</orcidid></search><sort><creationdate>201909</creationdate><title>Prevalence and determinants of vitamin D deficiency in infants and toddlers in the Netherlands: a pilot study</title><author>Hoevenaar-Blom, Marieke P ; Wielders, Jos PM ; Groeneveld, Henk ; de Leeuw, Elly ; Schmits, Ruben JH ; Pepermans, Carolien ; Pasker-de Jong, Pieternel CM ; Hogeman, Paul HG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-490e730b9b498246fdc707a784e69437463cba945b34c61e6d351a5c238576663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Child, Preschool</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Netherlands</topic><topic>Pilot Projects</topic><topic>Prevalence</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoevenaar-Blom, Marieke P</creatorcontrib><creatorcontrib>Wielders, Jos PM</creatorcontrib><creatorcontrib>Groeneveld, Henk</creatorcontrib><creatorcontrib>de Leeuw, Elly</creatorcontrib><creatorcontrib>Schmits, Ruben JH</creatorcontrib><creatorcontrib>Pepermans, Carolien</creatorcontrib><creatorcontrib>Pasker-de Jong, Pieternel CM</creatorcontrib><creatorcontrib>Hogeman, Paul HG</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoevenaar-Blom, Marieke P</au><au>Wielders, Jos PM</au><au>Groeneveld, Henk</au><au>de Leeuw, Elly</au><au>Schmits, Ruben JH</au><au>Pepermans, Carolien</au><au>Pasker-de Jong, Pieternel CM</au><au>Hogeman, Paul HG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and determinants of vitamin D deficiency in infants and toddlers in the Netherlands: a pilot study</atitle><jtitle>Annals of clinical biochemistry</jtitle><addtitle>Ann Clin Biochem</addtitle><date>2019-09</date><risdate>2019</risdate><volume>56</volume><issue>5</issue><spage>613</spage><epage>618</epage><pages>613-618</pages><issn>0004-5632</issn><eissn>1758-1001</eissn><abstract>Background
Little is known of the vitamin D status of young infants and toddlers and its determinants in West Europe. The prevalence and determinants of vitamin D deficiency of children aged 6–48 months in the centre of the Netherlands (52°N) is investigated.
Methods
In a cross-sectional population study, randomly recruited infants and toddlers (n = 150) were studied using an online questionnaire and a physical examination either in late summer (n = 52) or in late winter (n = 98). Vitamin D analysis was performed by capillary blood sampling using dried bloodspots plus LC-MS/MS.
Results
In late winter, 32% of the children were vitamin D deficient (<50 nmol/L 25OH vitamin D3) with 5% severely deficient (<25 nmol/L). In late summer, 2% were deficient. The odds of vitamin D deficiency were higher in children aged 24–48 months, for those not using formula milk and those not adhering to the supplementation guidelines.
Conclusion
One-third of Dutch infants and toddlers were found to be vitamin D deficient in late winter. Suggested strategies for raising the vitamin D status may include improving the adherence to supplementation, a sensible sun exposure or the use of fortified foods. Special attention is needed for the children aged 24–48 months.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>31154805</pmid><doi>10.1177/0004563219857772</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3155-6373</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0004-5632 |
ispartof | Annals of clinical biochemistry, 2019-09, Vol.56 (5), p.613-618 |
issn | 0004-5632 1758-1001 |
language | eng |
recordid | cdi_proquest_miscellaneous_2234483051 |
source | MEDLINE; SAGE Complete |
subjects | Child, Preschool Dietary Supplements Female Humans Infant Male Netherlands Pilot Projects Prevalence Vitamin D - blood Vitamin D Deficiency - epidemiology |
title | Prevalence and determinants of vitamin D deficiency in infants and toddlers in the Netherlands: a pilot study |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T04%3A13%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20and%20determinants%20of%20vitamin%20D%20deficiency%20in%20infants%20and%20toddlers%20in%20the%20Netherlands:%20a%20pilot%20study&rft.jtitle=Annals%20of%20clinical%20biochemistry&rft.au=Hoevenaar-Blom,%20Marieke%20P&rft.date=2019-09&rft.volume=56&rft.issue=5&rft.spage=613&rft.epage=618&rft.pages=613-618&rft.issn=0004-5632&rft.eissn=1758-1001&rft_id=info:doi/10.1177/0004563219857772&rft_dat=%3Cproquest_cross%3E2234483051%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2234483051&rft_id=info:pmid/31154805&rft_sage_id=10.1177_0004563219857772&rfr_iscdi=true |