The cross talk of adrenal and Leydig cell steroids in Leydig cells

•Glucocorticoid binds to GR to inhibit testosterone production in Leydig cells.•Glucocorticoid binds to MR to stimulate testosterone production in Leydig cells.•11β-Hydroxysteroid dehydrogenases control glucocorticoid levels in Leydig cells.•11β-Hydroxysteroid dehydrogenase 1 direction is coupled by...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2019-09, Vol.192, p.105386-105386, Article 105386
Hauptverfasser:	Wang, Yiyan, Li, Huitao, Zhu, Qiqi, Li, Xiaoheng, Lin, Zhenkun, Ge, Ren-Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism 11β-Hydroxysteroid dehydrogenase Adrenal cortex Adrenal glands Adrenal Glands - metabolism Animals Corticosterone - metabolism Dehydrogenases Enzymes Gene expression Glucocorticoid Glucocorticoids Glucocorticoids - metabolism Humans Intracellular Intracellular levels Intracellular receptor transcription factor Leydig cells Leydig Cells - metabolism Male Mineralocorticoid receptors NADP Redox potential Steroid hormones Steroidogenesis Testosterone Testosterone - metabolism
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