Polymeric nanoparticles responsive to intracellular ROS for anticancer drug delivery
[Display omitted] •Three ROS-responsive amphiphilic copolymers were synthesized.•The ROS-sensitivity of the self-assembled copolymers micelles was investigated.•mPEG-poly(ester-thioether) micelles exhibited the best ROS-responsive drug release and in vitro anticancer activity. Thioketal and thioethe...
Gespeichert in:
| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2019-09, Vol.181, p.252-260 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 260 |
|---|---|
| container_issue | |
| container_start_page | 252 |
| container_title | Colloids and surfaces, B, Biointerfaces |
| container_volume | 181 |
| creator | Xu, Long Zhao, Mingying Gao, Wenxia Yang, Yidi Zhang, Jianfeng Pu, Yuji He, Bin |
| description | [Display omitted]
•Three ROS-responsive amphiphilic copolymers were synthesized.•The ROS-sensitivity of the self-assembled copolymers micelles was investigated.•mPEG-poly(ester-thioether) micelles exhibited the best ROS-responsive drug release and in vitro anticancer activity.
Thioketal and thioether are moieties used to fabricate reactive oxygen species (ROS)-responsive polymers for drug delivery. In this paper, three amphiphilic copolymers of mPEG-poly(ester-thioether), mPEG-poly(thioketal-ester) and mPEG-poly(thioketal-ester-thioether) were synthesized. The ROS-responsive behaviors of the three copolymers nanoparticles as drug carriers were investigated. The ROS-sensitivity was demonstrated by NMR, DLS, and SEM. mPEG-poly(ester-thioether) nanoparticles exhibited the fastest drug release rate, which possessed the best ROS sensitivity. The in vitro anticancer activity of the DOX-loaded nanoparticles was studied, the results revealed that the mPEG-poly(ester-thioether) nanoparticles showed the most efficient anticancer activity. Notably, all the three ROS-responsive copolymers nanoparticles showed enhanced cellular uptake and anticancer efficacy comparing to the control mPEG-b-PCL nanoparticles. |
| doi_str_mv | 10.1016/j.colsurfb.2019.05.064 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2233864513</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0927776519303832</els_id><sourcerecordid>2233864513</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-662b56446090008a4971b22960186e5a55d4e15179118bb1a806be9b58728a4f3</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhq0K1G4__kLlI5eEGccfyQ1UUUCqVATlbDnOBHmVjRc7qbT_Hq-25drTXJ6Z952HsVuEGgH1x23t45TXNPa1AOxqUDVoecY22Jqmko0279gGOmEqY7S6YJc5bwFASDTn7KJBVA0I2LCnH3E67CgFz2c3x71LS_ATZZ4o7-OcwzPxJfIwL8l5mqZ1con_fPzFx5i4mwvsZk-JD2n9wweaCp8O1-z96KZMNy_ziv2-__J09616ePz6_e7zQ-UlqKXSWvRKS6mhK9VaJzuDvRCdBmw1KafUIAkVmg6x7Xt0Leieul61RhR6bK7Yh9PdfYp_V8qL3YV8bOlmimu2QjRNq6XCpqD6hPoUc0402n0KO5cOFsEejdqtfTVqj0YtKFuMlsXbl4y139Hwf-1VYQE-nQAqnz4HSjb7QEXKEBL5xQ4xvJXxDzZ6ioA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2233864513</pqid></control><display><type>article</type><title>Polymeric nanoparticles responsive to intracellular ROS for anticancer drug delivery</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Xu, Long ; Zhao, Mingying ; Gao, Wenxia ; Yang, Yidi ; Zhang, Jianfeng ; Pu, Yuji ; He, Bin</creator><creatorcontrib>Xu, Long ; Zhao, Mingying ; Gao, Wenxia ; Yang, Yidi ; Zhang, Jianfeng ; Pu, Yuji ; He, Bin</creatorcontrib><description>[Display omitted]
•Three ROS-responsive amphiphilic copolymers were synthesized.•The ROS-sensitivity of the self-assembled copolymers micelles was investigated.•mPEG-poly(ester-thioether) micelles exhibited the best ROS-responsive drug release and in vitro anticancer activity.
Thioketal and thioether are moieties used to fabricate reactive oxygen species (ROS)-responsive polymers for drug delivery. In this paper, three amphiphilic copolymers of mPEG-poly(ester-thioether), mPEG-poly(thioketal-ester) and mPEG-poly(thioketal-ester-thioether) were synthesized. The ROS-responsive behaviors of the three copolymers nanoparticles as drug carriers were investigated. The ROS-sensitivity was demonstrated by NMR, DLS, and SEM. mPEG-poly(ester-thioether) nanoparticles exhibited the fastest drug release rate, which possessed the best ROS sensitivity. The in vitro anticancer activity of the DOX-loaded nanoparticles was studied, the results revealed that the mPEG-poly(ester-thioether) nanoparticles showed the most efficient anticancer activity. Notably, all the three ROS-responsive copolymers nanoparticles showed enhanced cellular uptake and anticancer efficacy comparing to the control mPEG-b-PCL nanoparticles.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2019.05.064</identifier><identifier>PMID: 31153020</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Antibiotics, Antineoplastic - chemical synthesis ; Antibiotics, Antineoplastic - chemistry ; Antibiotics, Antineoplastic - pharmacology ; Cell Line, Tumor ; Cell Survival - drug effects ; Doxorubicin - chemical synthesis ; Doxorubicin - chemistry ; Doxorubicin - pharmacology ; Drug Carriers - chemistry ; Drug delivery ; Drug Delivery Systems ; Drug Liberation ; Drug Screening Assays, Antitumor ; HeLa Cells ; Humans ; Micelles ; Molecular Structure ; Nanoparticles ; Nanoparticles - chemistry ; Poly(ester-thioether) ; Polymers - chemistry ; Reactive Oxygen Species - metabolism ; ROS-responsive</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2019-09, Vol.181, p.252-260</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-662b56446090008a4971b22960186e5a55d4e15179118bb1a806be9b58728a4f3</citedby><cites>FETCH-LOGICAL-c405t-662b56446090008a4971b22960186e5a55d4e15179118bb1a806be9b58728a4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.colsurfb.2019.05.064$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31153020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Long</creatorcontrib><creatorcontrib>Zhao, Mingying</creatorcontrib><creatorcontrib>Gao, Wenxia</creatorcontrib><creatorcontrib>Yang, Yidi</creatorcontrib><creatorcontrib>Zhang, Jianfeng</creatorcontrib><creatorcontrib>Pu, Yuji</creatorcontrib><creatorcontrib>He, Bin</creatorcontrib><title>Polymeric nanoparticles responsive to intracellular ROS for anticancer drug delivery</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>[Display omitted]
•Three ROS-responsive amphiphilic copolymers were synthesized.•The ROS-sensitivity of the self-assembled copolymers micelles was investigated.•mPEG-poly(ester-thioether) micelles exhibited the best ROS-responsive drug release and in vitro anticancer activity.
Thioketal and thioether are moieties used to fabricate reactive oxygen species (ROS)-responsive polymers for drug delivery. In this paper, three amphiphilic copolymers of mPEG-poly(ester-thioether), mPEG-poly(thioketal-ester) and mPEG-poly(thioketal-ester-thioether) were synthesized. The ROS-responsive behaviors of the three copolymers nanoparticles as drug carriers were investigated. The ROS-sensitivity was demonstrated by NMR, DLS, and SEM. mPEG-poly(ester-thioether) nanoparticles exhibited the fastest drug release rate, which possessed the best ROS sensitivity. The in vitro anticancer activity of the DOX-loaded nanoparticles was studied, the results revealed that the mPEG-poly(ester-thioether) nanoparticles showed the most efficient anticancer activity. Notably, all the three ROS-responsive copolymers nanoparticles showed enhanced cellular uptake and anticancer efficacy comparing to the control mPEG-b-PCL nanoparticles.</description><subject>Antibiotics, Antineoplastic - chemical synthesis</subject><subject>Antibiotics, Antineoplastic - chemistry</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Doxorubicin - chemical synthesis</subject><subject>Doxorubicin - chemistry</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Carriers - chemistry</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Drug Liberation</subject><subject>Drug Screening Assays, Antitumor</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Micelles</subject><subject>Molecular Structure</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Poly(ester-thioether)</subject><subject>Polymers - chemistry</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>ROS-responsive</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhq0K1G4__kLlI5eEGccfyQ1UUUCqVATlbDnOBHmVjRc7qbT_Hq-25drTXJ6Z952HsVuEGgH1x23t45TXNPa1AOxqUDVoecY22Jqmko0279gGOmEqY7S6YJc5bwFASDTn7KJBVA0I2LCnH3E67CgFz2c3x71LS_ATZZ4o7-OcwzPxJfIwL8l5mqZ1con_fPzFx5i4mwvsZk-JD2n9wweaCp8O1-z96KZMNy_ziv2-__J09616ePz6_e7zQ-UlqKXSWvRKS6mhK9VaJzuDvRCdBmw1KafUIAkVmg6x7Xt0Leieul61RhR6bK7Yh9PdfYp_V8qL3YV8bOlmimu2QjRNq6XCpqD6hPoUc0402n0KO5cOFsEejdqtfTVqj0YtKFuMlsXbl4y139Hwf-1VYQE-nQAqnz4HSjb7QEXKEBL5xQ4xvJXxDzZ6ioA</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Xu, Long</creator><creator>Zhao, Mingying</creator><creator>Gao, Wenxia</creator><creator>Yang, Yidi</creator><creator>Zhang, Jianfeng</creator><creator>Pu, Yuji</creator><creator>He, Bin</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190901</creationdate><title>Polymeric nanoparticles responsive to intracellular ROS for anticancer drug delivery</title><author>Xu, Long ; Zhao, Mingying ; Gao, Wenxia ; Yang, Yidi ; Zhang, Jianfeng ; Pu, Yuji ; He, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-662b56446090008a4971b22960186e5a55d4e15179118bb1a806be9b58728a4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antibiotics, Antineoplastic - chemical synthesis</topic><topic>Antibiotics, Antineoplastic - chemistry</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Doxorubicin - chemical synthesis</topic><topic>Doxorubicin - chemistry</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Carriers - chemistry</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems</topic><topic>Drug Liberation</topic><topic>Drug Screening Assays, Antitumor</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Micelles</topic><topic>Molecular Structure</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Poly(ester-thioether)</topic><topic>Polymers - chemistry</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>ROS-responsive</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Long</creatorcontrib><creatorcontrib>Zhao, Mingying</creatorcontrib><creatorcontrib>Gao, Wenxia</creatorcontrib><creatorcontrib>Yang, Yidi</creatorcontrib><creatorcontrib>Zhang, Jianfeng</creatorcontrib><creatorcontrib>Pu, Yuji</creatorcontrib><creatorcontrib>He, Bin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Long</au><au>Zhao, Mingying</au><au>Gao, Wenxia</au><au>Yang, Yidi</au><au>Zhang, Jianfeng</au><au>Pu, Yuji</au><au>He, Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymeric nanoparticles responsive to intracellular ROS for anticancer drug delivery</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>181</volume><spage>252</spage><epage>260</epage><pages>252-260</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>[Display omitted]
•Three ROS-responsive amphiphilic copolymers were synthesized.•The ROS-sensitivity of the self-assembled copolymers micelles was investigated.•mPEG-poly(ester-thioether) micelles exhibited the best ROS-responsive drug release and in vitro anticancer activity.
Thioketal and thioether are moieties used to fabricate reactive oxygen species (ROS)-responsive polymers for drug delivery. In this paper, three amphiphilic copolymers of mPEG-poly(ester-thioether), mPEG-poly(thioketal-ester) and mPEG-poly(thioketal-ester-thioether) were synthesized. The ROS-responsive behaviors of the three copolymers nanoparticles as drug carriers were investigated. The ROS-sensitivity was demonstrated by NMR, DLS, and SEM. mPEG-poly(ester-thioether) nanoparticles exhibited the fastest drug release rate, which possessed the best ROS sensitivity. The in vitro anticancer activity of the DOX-loaded nanoparticles was studied, the results revealed that the mPEG-poly(ester-thioether) nanoparticles showed the most efficient anticancer activity. Notably, all the three ROS-responsive copolymers nanoparticles showed enhanced cellular uptake and anticancer efficacy comparing to the control mPEG-b-PCL nanoparticles.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31153020</pmid><doi>10.1016/j.colsurfb.2019.05.064</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0927-7765 |
| ispartof | Colloids and surfaces, B, Biointerfaces, 2019-09, Vol.181, p.252-260 |
| issn | 0927-7765 1873-4367 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2233864513 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Antibiotics, Antineoplastic - chemical synthesis Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Cell Line, Tumor Cell Survival - drug effects Doxorubicin - chemical synthesis Doxorubicin - chemistry Doxorubicin - pharmacology Drug Carriers - chemistry Drug delivery Drug Delivery Systems Drug Liberation Drug Screening Assays, Antitumor HeLa Cells Humans Micelles Molecular Structure Nanoparticles Nanoparticles - chemistry Poly(ester-thioether) Polymers - chemistry Reactive Oxygen Species - metabolism ROS-responsive |
| title | Polymeric nanoparticles responsive to intracellular ROS for anticancer drug delivery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T20%3A08%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polymeric%20nanoparticles%20responsive%20to%20intracellular%20ROS%20for%20anticancer%20drug%20delivery&rft.jtitle=Colloids%20and%20surfaces,%20B,%20Biointerfaces&rft.au=Xu,%20Long&rft.date=2019-09-01&rft.volume=181&rft.spage=252&rft.epage=260&rft.pages=252-260&rft.issn=0927-7765&rft.eissn=1873-4367&rft_id=info:doi/10.1016/j.colsurfb.2019.05.064&rft_dat=%3Cproquest_cross%3E2233864513%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2233864513&rft_id=info:pmid/31153020&rft_els_id=S0927776519303832&rfr_iscdi=true |