Profile of Polish patients with primary progressive multiple sclerosis
•Patients with PPMS account for approximately 10% of all patients with multiple sclerosis.•The first symptoms of PPMS occur at around the age of 40 with a similar frequency in both sexes.•PPMS diagnosis takes more than twice the time for RRMS.•The dominant symptom of PPMS is spastic paresis of the l...
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| Veröffentlicht in: | Multiple sclerosis and related disorders 2019-08, Vol.33, p.33-38 |
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| creator | Brola, Waldemar Sobolewski, Piotr Żak, Marek Flaga, Stanisław Fudala, Małgorzata Siutka, Dominik Kapica, Katarzyna Chorąży, Monika Kułakowska, Alina Perenc, Adam Bartosik-Psujek, Halina Psujek, Marek Głąbiński, Andrzej Pawełczyk, Małgorzata Gacek, Szymon Potemkowski, Andrzej |
| description | •Patients with PPMS account for approximately 10% of all patients with multiple sclerosis.•The first symptoms of PPMS occur at around the age of 40 with a similar frequency in both sexes.•PPMS diagnosis takes more than twice the time for RRMS.•The dominant symptom of PPMS is spastic paresis of the lower limbs.
Epidemiologic data on primary progressive multiple sclerosis (PPMS) in Poland are limited. The aim of this study was to assess selected clinical and socio-demographic factors of Polish patients with PPMS and compare this form and relapsing-remitting (RRMS) and secondary progressive (SPMS) forms.
Patients who attended follow-up visits under the Registry of Patients with Multiple Sclerosis (RejSM) were enrolled in the study in the autumn of 2017. The prevalence of individual types of the disease was compared and the clinical, demographic, and social differences between RRMS, PPMS and SPMS were analyzed.
Of the 8,045 registered patients, current data as on December 31, 2017 was obtained from 4,398 patients. The RRMS form was seen in 2,925 patients (66.5%); secondary progressive form, in 1.051 patients (23.9%); and PPMS, in 422 patients (9.6%). The first symptoms of PPMS appeared almost 10 years later than in patients with RRMS (39.2 ± 11.4 vs. 29.8 ± 9.8). The period from the first symptoms to diagnosis was more than twice as long in patients with PPMS (5.8 ± 3.4) than RRMS (2.4 ± 1.6). SPMS was diagnosed on average after 14 years of RRMS (46.2 ± 13.5). The RRMS form was more frequently found in women (2.4:1), while the PPMS form was almost equal in both sexes (1.2:1). The average degree of disability based on the Expanded Disability Status Scale was 3.2 ± 2.1 for RRMS, 4.6 ± 2.4 for PPMS and 5.2 ± 3.6 for SPMS. The dominant symptom in PPMS was paresis of the lower limbs (86%). Patients with PPMS had higher education and higher instance of marriage than those with RRMS or SPMS.
PPMS occurs in about 10% of Polish patients with multiple sclerosis, and the first symptoms appear at around 40 years of age with the same frequency in both sexes. PPMS diagnosis takes more than twice the time for RRMS. |
| doi_str_mv | 10.1016/j.msard.2019.05.009 |
| format | Article |
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Epidemiologic data on primary progressive multiple sclerosis (PPMS) in Poland are limited. The aim of this study was to assess selected clinical and socio-demographic factors of Polish patients with PPMS and compare this form and relapsing-remitting (RRMS) and secondary progressive (SPMS) forms.
Patients who attended follow-up visits under the Registry of Patients with Multiple Sclerosis (RejSM) were enrolled in the study in the autumn of 2017. The prevalence of individual types of the disease was compared and the clinical, demographic, and social differences between RRMS, PPMS and SPMS were analyzed.
Of the 8,045 registered patients, current data as on December 31, 2017 was obtained from 4,398 patients. The RRMS form was seen in 2,925 patients (66.5%); secondary progressive form, in 1.051 patients (23.9%); and PPMS, in 422 patients (9.6%). The first symptoms of PPMS appeared almost 10 years later than in patients with RRMS (39.2 ± 11.4 vs. 29.8 ± 9.8). The period from the first symptoms to diagnosis was more than twice as long in patients with PPMS (5.8 ± 3.4) than RRMS (2.4 ± 1.6). SPMS was diagnosed on average after 14 years of RRMS (46.2 ± 13.5). The RRMS form was more frequently found in women (2.4:1), while the PPMS form was almost equal in both sexes (1.2:1). The average degree of disability based on the Expanded Disability Status Scale was 3.2 ± 2.1 for RRMS, 4.6 ± 2.4 for PPMS and 5.2 ± 3.6 for SPMS. The dominant symptom in PPMS was paresis of the lower limbs (86%). Patients with PPMS had higher education and higher instance of marriage than those with RRMS or SPMS.
PPMS occurs in about 10% of Polish patients with multiple sclerosis, and the first symptoms appear at around 40 years of age with the same frequency in both sexes. PPMS diagnosis takes more than twice the time for RRMS.</description><identifier>ISSN: 2211-0348</identifier><identifier>EISSN: 2211-0356</identifier><identifier>DOI: 10.1016/j.msard.2019.05.009</identifier><identifier>PMID: 31146082</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Epidemiology ; Female ; Humans ; Male ; Multiple sclerosis ; Multiple Sclerosis, Chronic Progressive - diagnosis ; Multiple Sclerosis, Chronic Progressive - epidemiology ; Multiple Sclerosis, Relapsing-Remitting - diagnosis ; Multiple Sclerosis, Relapsing-Remitting - epidemiology ; Poland ; Poland - epidemiology ; Progressive form ; Relapsing-remitting form</subject><ispartof>Multiple sclerosis and related disorders, 2019-08, Vol.33, p.33-38</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-5e7a4edd4348e269908e956acaa25a846dca2dfc0de8c878ffd92c3bec87776a3</citedby><cites>FETCH-LOGICAL-c359t-5e7a4edd4348e269908e956acaa25a846dca2dfc0de8c878ffd92c3bec87776a3</cites><orcidid>0000-0001-8162-8649 ; 0000-0002-0583-2514 ; 0000-0002-7955-3454 ; 0000-0002-9720-3204 ; 0000-0002-2860-6456</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31146082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brola, Waldemar</creatorcontrib><creatorcontrib>Sobolewski, Piotr</creatorcontrib><creatorcontrib>Żak, Marek</creatorcontrib><creatorcontrib>Flaga, Stanisław</creatorcontrib><creatorcontrib>Fudala, Małgorzata</creatorcontrib><creatorcontrib>Siutka, Dominik</creatorcontrib><creatorcontrib>Kapica, Katarzyna</creatorcontrib><creatorcontrib>Chorąży, Monika</creatorcontrib><creatorcontrib>Kułakowska, Alina</creatorcontrib><creatorcontrib>Perenc, Adam</creatorcontrib><creatorcontrib>Bartosik-Psujek, Halina</creatorcontrib><creatorcontrib>Psujek, Marek</creatorcontrib><creatorcontrib>Głąbiński, Andrzej</creatorcontrib><creatorcontrib>Pawełczyk, Małgorzata</creatorcontrib><creatorcontrib>Gacek, Szymon</creatorcontrib><creatorcontrib>Potemkowski, Andrzej</creatorcontrib><title>Profile of Polish patients with primary progressive multiple sclerosis</title><title>Multiple sclerosis and related disorders</title><addtitle>Mult Scler Relat Disord</addtitle><description>•Patients with PPMS account for approximately 10% of all patients with multiple sclerosis.•The first symptoms of PPMS occur at around the age of 40 with a similar frequency in both sexes.•PPMS diagnosis takes more than twice the time for RRMS.•The dominant symptom of PPMS is spastic paresis of the lower limbs.
Epidemiologic data on primary progressive multiple sclerosis (PPMS) in Poland are limited. The aim of this study was to assess selected clinical and socio-demographic factors of Polish patients with PPMS and compare this form and relapsing-remitting (RRMS) and secondary progressive (SPMS) forms.
Patients who attended follow-up visits under the Registry of Patients with Multiple Sclerosis (RejSM) were enrolled in the study in the autumn of 2017. The prevalence of individual types of the disease was compared and the clinical, demographic, and social differences between RRMS, PPMS and SPMS were analyzed.
Of the 8,045 registered patients, current data as on December 31, 2017 was obtained from 4,398 patients. The RRMS form was seen in 2,925 patients (66.5%); secondary progressive form, in 1.051 patients (23.9%); and PPMS, in 422 patients (9.6%). The first symptoms of PPMS appeared almost 10 years later than in patients with RRMS (39.2 ± 11.4 vs. 29.8 ± 9.8). The period from the first symptoms to diagnosis was more than twice as long in patients with PPMS (5.8 ± 3.4) than RRMS (2.4 ± 1.6). SPMS was diagnosed on average after 14 years of RRMS (46.2 ± 13.5). The RRMS form was more frequently found in women (2.4:1), while the PPMS form was almost equal in both sexes (1.2:1). The average degree of disability based on the Expanded Disability Status Scale was 3.2 ± 2.1 for RRMS, 4.6 ± 2.4 for PPMS and 5.2 ± 3.6 for SPMS. The dominant symptom in PPMS was paresis of the lower limbs (86%). Patients with PPMS had higher education and higher instance of marriage than those with RRMS or SPMS.
PPMS occurs in about 10% of Polish patients with multiple sclerosis, and the first symptoms appear at around 40 years of age with the same frequency in both sexes. PPMS diagnosis takes more than twice the time for RRMS.</description><subject>Adult</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis, Chronic Progressive - diagnosis</subject><subject>Multiple Sclerosis, Chronic Progressive - epidemiology</subject><subject>Multiple Sclerosis, Relapsing-Remitting - diagnosis</subject><subject>Multiple Sclerosis, Relapsing-Remitting - epidemiology</subject><subject>Poland</subject><subject>Poland - epidemiology</subject><subject>Progressive form</subject><subject>Relapsing-remitting form</subject><issn>2211-0348</issn><issn>2211-0356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDFPwzAQhS0EohX0FyChjCwJthM7zsCAKgpIlegAs-XaF3CVNMWXFPHvcWnpiJe7k97zvfsIuWI0Y5TJ21XWogku45RVGRUZpdUJGXPOWEpzIU-PfaFGZIK4ovFJwQrJzskoZ7Ghio_JbBG62jeQdHWy6BqPH8nG9B7WPSZfvo9T8K0J37F27wEQ_RaSdmh6v4kmtA2EDj1ekrPaNAiTQ70gb7OH1-lTOn95fJ7ez1Obi6pPBZSmAOeKGAu4rCqqoBLSWGO4MKqQzhruaksdKKtKVdeu4jZfQhzKUpr8gtzs_41xPgfAXrceLTSNWUM3oOY8z5VQnKsozfdSGxNigFofTtGM6h1DvdK_DPWOoaZCR4bRdX1YMCxbcEfPH7EouNsLIJ659RA02ojLgvMBbK9d5_9d8ANU0oTH</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Brola, Waldemar</creator><creator>Sobolewski, Piotr</creator><creator>Żak, Marek</creator><creator>Flaga, Stanisław</creator><creator>Fudala, Małgorzata</creator><creator>Siutka, Dominik</creator><creator>Kapica, Katarzyna</creator><creator>Chorąży, Monika</creator><creator>Kułakowska, Alina</creator><creator>Perenc, Adam</creator><creator>Bartosik-Psujek, Halina</creator><creator>Psujek, Marek</creator><creator>Głąbiński, Andrzej</creator><creator>Pawełczyk, Małgorzata</creator><creator>Gacek, Szymon</creator><creator>Potemkowski, Andrzej</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8162-8649</orcidid><orcidid>https://orcid.org/0000-0002-0583-2514</orcidid><orcidid>https://orcid.org/0000-0002-7955-3454</orcidid><orcidid>https://orcid.org/0000-0002-9720-3204</orcidid><orcidid>https://orcid.org/0000-0002-2860-6456</orcidid></search><sort><creationdate>201908</creationdate><title>Profile of Polish patients with primary progressive multiple sclerosis</title><author>Brola, Waldemar ; Sobolewski, Piotr ; Żak, Marek ; Flaga, Stanisław ; Fudala, Małgorzata ; Siutka, Dominik ; Kapica, Katarzyna ; Chorąży, Monika ; Kułakowska, Alina ; Perenc, Adam ; Bartosik-Psujek, Halina ; Psujek, Marek ; Głąbiński, Andrzej ; Pawełczyk, Małgorzata ; Gacek, Szymon ; Potemkowski, Andrzej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-5e7a4edd4348e269908e956acaa25a846dca2dfc0de8c878ffd92c3bec87776a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis, Chronic Progressive - diagnosis</topic><topic>Multiple Sclerosis, Chronic Progressive - epidemiology</topic><topic>Multiple Sclerosis, Relapsing-Remitting - diagnosis</topic><topic>Multiple Sclerosis, Relapsing-Remitting - epidemiology</topic><topic>Poland</topic><topic>Poland - epidemiology</topic><topic>Progressive form</topic><topic>Relapsing-remitting form</topic><toplevel>online_resources</toplevel><creatorcontrib>Brola, Waldemar</creatorcontrib><creatorcontrib>Sobolewski, Piotr</creatorcontrib><creatorcontrib>Żak, Marek</creatorcontrib><creatorcontrib>Flaga, Stanisław</creatorcontrib><creatorcontrib>Fudala, Małgorzata</creatorcontrib><creatorcontrib>Siutka, Dominik</creatorcontrib><creatorcontrib>Kapica, Katarzyna</creatorcontrib><creatorcontrib>Chorąży, Monika</creatorcontrib><creatorcontrib>Kułakowska, Alina</creatorcontrib><creatorcontrib>Perenc, Adam</creatorcontrib><creatorcontrib>Bartosik-Psujek, Halina</creatorcontrib><creatorcontrib>Psujek, Marek</creatorcontrib><creatorcontrib>Głąbiński, Andrzej</creatorcontrib><creatorcontrib>Pawełczyk, Małgorzata</creatorcontrib><creatorcontrib>Gacek, Szymon</creatorcontrib><creatorcontrib>Potemkowski, Andrzej</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Multiple sclerosis and related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brola, Waldemar</au><au>Sobolewski, Piotr</au><au>Żak, Marek</au><au>Flaga, Stanisław</au><au>Fudala, Małgorzata</au><au>Siutka, Dominik</au><au>Kapica, Katarzyna</au><au>Chorąży, Monika</au><au>Kułakowska, Alina</au><au>Perenc, Adam</au><au>Bartosik-Psujek, Halina</au><au>Psujek, Marek</au><au>Głąbiński, Andrzej</au><au>Pawełczyk, Małgorzata</au><au>Gacek, Szymon</au><au>Potemkowski, Andrzej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Profile of Polish patients with primary progressive multiple sclerosis</atitle><jtitle>Multiple sclerosis and related disorders</jtitle><addtitle>Mult Scler Relat Disord</addtitle><date>2019-08</date><risdate>2019</risdate><volume>33</volume><spage>33</spage><epage>38</epage><pages>33-38</pages><issn>2211-0348</issn><eissn>2211-0356</eissn><abstract>•Patients with PPMS account for approximately 10% of all patients with multiple sclerosis.•The first symptoms of PPMS occur at around the age of 40 with a similar frequency in both sexes.•PPMS diagnosis takes more than twice the time for RRMS.•The dominant symptom of PPMS is spastic paresis of the lower limbs.
Epidemiologic data on primary progressive multiple sclerosis (PPMS) in Poland are limited. The aim of this study was to assess selected clinical and socio-demographic factors of Polish patients with PPMS and compare this form and relapsing-remitting (RRMS) and secondary progressive (SPMS) forms.
Patients who attended follow-up visits under the Registry of Patients with Multiple Sclerosis (RejSM) were enrolled in the study in the autumn of 2017. The prevalence of individual types of the disease was compared and the clinical, demographic, and social differences between RRMS, PPMS and SPMS were analyzed.
Of the 8,045 registered patients, current data as on December 31, 2017 was obtained from 4,398 patients. The RRMS form was seen in 2,925 patients (66.5%); secondary progressive form, in 1.051 patients (23.9%); and PPMS, in 422 patients (9.6%). The first symptoms of PPMS appeared almost 10 years later than in patients with RRMS (39.2 ± 11.4 vs. 29.8 ± 9.8). The period from the first symptoms to diagnosis was more than twice as long in patients with PPMS (5.8 ± 3.4) than RRMS (2.4 ± 1.6). SPMS was diagnosed on average after 14 years of RRMS (46.2 ± 13.5). The RRMS form was more frequently found in women (2.4:1), while the PPMS form was almost equal in both sexes (1.2:1). The average degree of disability based on the Expanded Disability Status Scale was 3.2 ± 2.1 for RRMS, 4.6 ± 2.4 for PPMS and 5.2 ± 3.6 for SPMS. The dominant symptom in PPMS was paresis of the lower limbs (86%). Patients with PPMS had higher education and higher instance of marriage than those with RRMS or SPMS.
PPMS occurs in about 10% of Polish patients with multiple sclerosis, and the first symptoms appear at around 40 years of age with the same frequency in both sexes. PPMS diagnosis takes more than twice the time for RRMS.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31146082</pmid><doi>10.1016/j.msard.2019.05.009</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8162-8649</orcidid><orcidid>https://orcid.org/0000-0002-0583-2514</orcidid><orcidid>https://orcid.org/0000-0002-7955-3454</orcidid><orcidid>https://orcid.org/0000-0002-9720-3204</orcidid><orcidid>https://orcid.org/0000-0002-2860-6456</orcidid></addata></record> |
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| ispartof | Multiple sclerosis and related disorders, 2019-08, Vol.33, p.33-38 |
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| subjects | Adult Epidemiology Female Humans Male Multiple sclerosis Multiple Sclerosis, Chronic Progressive - diagnosis Multiple Sclerosis, Chronic Progressive - epidemiology Multiple Sclerosis, Relapsing-Remitting - diagnosis Multiple Sclerosis, Relapsing-Remitting - epidemiology Poland Poland - epidemiology Progressive form Relapsing-remitting form |
| title | Profile of Polish patients with primary progressive multiple sclerosis |
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