Plasma levels of von Willebrand factor in type 2 diabetes patients with and without cardiovascular diseases: A meta‐analysis
Summary Chronic vascular complications are the major causes of death and disability of type 2 diabetes mellitus (T2DM) patients. von Willebrand factor (vWF) is involved in pathogenesis of cardiovascular diseases (CVD). Previous studies showed elevated plasma levels of vWF in T2DM patients with CVD,...
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| Veröffentlicht in: | Diabetes/metabolism research and reviews 2020-01, Vol.36 (1), p.e3193-n/a |
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| creator | Peng, Xun Wang, Xia Fan, Mengge Zhao, Junyu Lin, Liao Liu, Ju |
| description | Summary
Chronic vascular complications are the major causes of death and disability of type 2 diabetes mellitus (T2DM) patients. von Willebrand factor (vWF) is involved in pathogenesis of cardiovascular diseases (CVD). Previous studies showed elevated plasma levels of vWF in T2DM patients with CVD, but the association has not been validated. The aim of this meta‐analysis was to compare plasma levels of vWF in T2DM patients with and without CVD. We performed a meta‐analysis based on published case‐control studies of vWF in T2DM patients with and without CVD indexed in PubMed and other databases updated to April 2018. After independently assessing methodological quality and extracting data, 9 eligible studies were obtained including 576 cases and 632 controls. The standard mean difference (SMD) and 95% confidence intervals (95% CI) were calculated using random‐effects model. Meta‐analysis showed that plasma level of vWF was significantly higher in T2DM patients with CVD than T2DM patients without CVD (SMD = 0.61; 95% CI, 0.32‐0.90; P |
| doi_str_mv | 10.1002/dmrr.3193 |
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Chronic vascular complications are the major causes of death and disability of type 2 diabetes mellitus (T2DM) patients. von Willebrand factor (vWF) is involved in pathogenesis of cardiovascular diseases (CVD). Previous studies showed elevated plasma levels of vWF in T2DM patients with CVD, but the association has not been validated. The aim of this meta‐analysis was to compare plasma levels of vWF in T2DM patients with and without CVD. We performed a meta‐analysis based on published case‐control studies of vWF in T2DM patients with and without CVD indexed in PubMed and other databases updated to April 2018. After independently assessing methodological quality and extracting data, 9 eligible studies were obtained including 576 cases and 632 controls. The standard mean difference (SMD) and 95% confidence intervals (95% CI) were calculated using random‐effects model. Meta‐analysis showed that plasma level of vWF was significantly higher in T2DM patients with CVD than T2DM patients without CVD (SMD = 0.61; 95% CI, 0.32‐0.90; P < .00001). Subgroup and sensitivity analyses confirmed the robustness of the results. Plasma levels of vWF are significantly elevated in patients with T2DM complicated by CVD. This study helps further characterize the prognostic value of vWF for cardiovascular complications in T2DM patients.</description><identifier>ISSN: 1520-7552</identifier><identifier>EISSN: 1520-7560</identifier><identifier>DOI: 10.1002/dmrr.3193</identifier><identifier>PMID: 31145835</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>cardiovascular complications ; Cardiovascular diseases ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Meta-analysis ; Plasma ; Plasma levels ; Sensitivity analysis ; type 2 diabetes mellitus ; Von Willebrand factor</subject><ispartof>Diabetes/metabolism research and reviews, 2020-01, Vol.36 (1), p.e3193-n/a</ispartof><rights>2019 John Wiley & Sons, Ltd.</rights><rights>2020 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-1141eea8745629913f2b32e9bb0e9d387a05ce9bd69f337f6055737214004a183</citedby><cites>FETCH-LOGICAL-c3533-1141eea8745629913f2b32e9bb0e9d387a05ce9bd69f337f6055737214004a183</cites><orcidid>0000-0001-9932-2613</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdmrr.3193$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdmrr.3193$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31145835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Xun</creatorcontrib><creatorcontrib>Wang, Xia</creatorcontrib><creatorcontrib>Fan, Mengge</creatorcontrib><creatorcontrib>Zhao, Junyu</creatorcontrib><creatorcontrib>Lin, Liao</creatorcontrib><creatorcontrib>Liu, Ju</creatorcontrib><title>Plasma levels of von Willebrand factor in type 2 diabetes patients with and without cardiovascular diseases: A meta‐analysis</title><title>Diabetes/metabolism research and reviews</title><addtitle>Diabetes Metab Res Rev</addtitle><description>Summary
Chronic vascular complications are the major causes of death and disability of type 2 diabetes mellitus (T2DM) patients. von Willebrand factor (vWF) is involved in pathogenesis of cardiovascular diseases (CVD). Previous studies showed elevated plasma levels of vWF in T2DM patients with CVD, but the association has not been validated. The aim of this meta‐analysis was to compare plasma levels of vWF in T2DM patients with and without CVD. We performed a meta‐analysis based on published case‐control studies of vWF in T2DM patients with and without CVD indexed in PubMed and other databases updated to April 2018. After independently assessing methodological quality and extracting data, 9 eligible studies were obtained including 576 cases and 632 controls. The standard mean difference (SMD) and 95% confidence intervals (95% CI) were calculated using random‐effects model. Meta‐analysis showed that plasma level of vWF was significantly higher in T2DM patients with CVD than T2DM patients without CVD (SMD = 0.61; 95% CI, 0.32‐0.90; P < .00001). Subgroup and sensitivity analyses confirmed the robustness of the results. Plasma levels of vWF are significantly elevated in patients with T2DM complicated by CVD. This study helps further characterize the prognostic value of vWF for cardiovascular complications in T2DM patients.</description><subject>cardiovascular complications</subject><subject>Cardiovascular diseases</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Meta-analysis</subject><subject>Plasma</subject><subject>Plasma levels</subject><subject>Sensitivity analysis</subject><subject>type 2 diabetes mellitus</subject><subject>Von Willebrand factor</subject><issn>1520-7552</issn><issn>1520-7560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp10c1qFTEUB_AgFvuhC19AAm50cdskJ5kPd6V-VKgoRXE5nJk5gymZyTXJ3HI30kfwGfskZnprF4KrnMAv_xz4M_ZcimMphDrpxxCOQdbwiB1Io8SqNIV4_DAbtc8OY7wSQoAu9BO2D1JqU4E5YL--OIwjckcbcpH7gW_8xL9b56gNOPV8wC75wO3E03ZNXPHeYkuJIl9jsjSlyK9t-sEXuwx-TrzD0Fu_wdjNDkN-EQkjxTf8lI-U8PbmN07ottHGp2xvQBfp2f15xL69f_f17Hx18fnDx7PTi1UHBmCV15VEWJXaFKquJQyqBUV12wqqe6hKFKbL176oB4ByKIQxJZRKaiE0ygqO2Ktd7jr4nzPF1Iw2duQcTuTn2CgFUJmy0nWmL_-hV34Oed-sALQ2-bsiq9c71QUfY6ChWQc7Ytg2UjRLKc1SSrOUku2L-8S5Hal_kH9byOBkB66to-3_k5q3ny4v7yL_AA6Ol0w</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Peng, Xun</creator><creator>Wang, Xia</creator><creator>Fan, Mengge</creator><creator>Zhao, Junyu</creator><creator>Lin, Liao</creator><creator>Liu, Ju</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9932-2613</orcidid></search><sort><creationdate>202001</creationdate><title>Plasma levels of von Willebrand factor in type 2 diabetes patients with and without cardiovascular diseases: A meta‐analysis</title><author>Peng, Xun ; Wang, Xia ; Fan, Mengge ; Zhao, Junyu ; Lin, Liao ; Liu, Ju</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-1141eea8745629913f2b32e9bb0e9d387a05ce9bd69f337f6055737214004a183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>cardiovascular complications</topic><topic>Cardiovascular diseases</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Meta-analysis</topic><topic>Plasma</topic><topic>Plasma levels</topic><topic>Sensitivity analysis</topic><topic>type 2 diabetes mellitus</topic><topic>Von Willebrand factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Xun</creatorcontrib><creatorcontrib>Wang, Xia</creatorcontrib><creatorcontrib>Fan, Mengge</creatorcontrib><creatorcontrib>Zhao, Junyu</creatorcontrib><creatorcontrib>Lin, Liao</creatorcontrib><creatorcontrib>Liu, Ju</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes/metabolism research and reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Xun</au><au>Wang, Xia</au><au>Fan, Mengge</au><au>Zhao, Junyu</au><au>Lin, Liao</au><au>Liu, Ju</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma levels of von Willebrand factor in type 2 diabetes patients with and without cardiovascular diseases: A meta‐analysis</atitle><jtitle>Diabetes/metabolism research and reviews</jtitle><addtitle>Diabetes Metab Res Rev</addtitle><date>2020-01</date><risdate>2020</risdate><volume>36</volume><issue>1</issue><spage>e3193</spage><epage>n/a</epage><pages>e3193-n/a</pages><issn>1520-7552</issn><eissn>1520-7560</eissn><abstract>Summary
Chronic vascular complications are the major causes of death and disability of type 2 diabetes mellitus (T2DM) patients. von Willebrand factor (vWF) is involved in pathogenesis of cardiovascular diseases (CVD). Previous studies showed elevated plasma levels of vWF in T2DM patients with CVD, but the association has not been validated. The aim of this meta‐analysis was to compare plasma levels of vWF in T2DM patients with and without CVD. We performed a meta‐analysis based on published case‐control studies of vWF in T2DM patients with and without CVD indexed in PubMed and other databases updated to April 2018. After independently assessing methodological quality and extracting data, 9 eligible studies were obtained including 576 cases and 632 controls. The standard mean difference (SMD) and 95% confidence intervals (95% CI) were calculated using random‐effects model. Meta‐analysis showed that plasma level of vWF was significantly higher in T2DM patients with CVD than T2DM patients without CVD (SMD = 0.61; 95% CI, 0.32‐0.90; P < .00001). Subgroup and sensitivity analyses confirmed the robustness of the results. Plasma levels of vWF are significantly elevated in patients with T2DM complicated by CVD. This study helps further characterize the prognostic value of vWF for cardiovascular complications in T2DM patients.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31145835</pmid><doi>10.1002/dmrr.3193</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9932-2613</orcidid></addata></record> |
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| subjects | cardiovascular complications Cardiovascular diseases Diabetes Diabetes mellitus (non-insulin dependent) Meta-analysis Plasma Plasma levels Sensitivity analysis type 2 diabetes mellitus Von Willebrand factor |
| title | Plasma levels of von Willebrand factor in type 2 diabetes patients with and without cardiovascular diseases: A meta‐analysis |
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