Physiological complexity of gait between regular and non-exercisers with Parkinson's disease
Physiological complexity represents overall health of a system and its underlying capacity to adapt to stresses. The primary purpose of this study was to determine if physiological complexity of gait both ON and OFF anti-Parkinson medication differed between regular and non-exercisers with Parkinson...
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| Veröffentlicht in: | Clinical biomechanics (Bristol) 2019-08, Vol.68, p.23-28 |
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| container_title | Clinical biomechanics (Bristol) |
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| creator | Combs-Miller, Stephanie A. Dugan, Eric L. Beachy, Ann Derby, Brook B. Hosinski, Alicia L. Robbins, Kristen |
| description | Physiological complexity represents overall health of a system and its underlying capacity to adapt to stresses. The primary purpose of this study was to determine if physiological complexity of gait both ON and OFF anti-Parkinson medication differed between regular and non-exercisers with Parkinson's disease.
Twenty participants with idiopathic Parkinson's disease were enrolled in this cross-sectional study (regular exercisers n = 10, non-exercisers n = 10). Two data collection sessions were completed during a single visit, first after a 12-hour overnight withdrawal from anti-Parkinson medications (OFF), and again one-hour after taking anti-Parkinson medications (ON). During each session participants completed a 2-minute walking task at their preferred pace while wearing wireless inertial measurement units on each lower extremity segment (thigh, shank, foot). Multivariate multiscale entropy was calculated from the tri-axial accelerometer signals and converted to a complexity index for analysis.
Regular exercisers demonstrated significantly higher complexity indices ON and OFF anti-Parkinson medications compared to non-exercisers (ON F = 3.84 P = 0.02; OFF F = 3.61, P |
| doi_str_mv | 10.1016/j.clinbiomech.2019.05.032 |
| format | Article |
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Twenty participants with idiopathic Parkinson's disease were enrolled in this cross-sectional study (regular exercisers n = 10, non-exercisers n = 10). Two data collection sessions were completed during a single visit, first after a 12-hour overnight withdrawal from anti-Parkinson medications (OFF), and again one-hour after taking anti-Parkinson medications (ON). During each session participants completed a 2-minute walking task at their preferred pace while wearing wireless inertial measurement units on each lower extremity segment (thigh, shank, foot). Multivariate multiscale entropy was calculated from the tri-axial accelerometer signals and converted to a complexity index for analysis.
Regular exercisers demonstrated significantly higher complexity indices ON and OFF anti-Parkinson medications compared to non-exercisers (ON F = 3.84 P = 0.02; OFF F = 3.61, P < 0.03). Regular exercisers did not significantly differ in complexity between OFF and ON states (most affected leg F = 0.15 P = 0.71; least affected leg F = 0.30 P = 0.60), but non-exercisers demonstrated significantly decreased complexity in the least affected leg OFF anti-Parkinson medications (F = 5.17 P < 0.04).
Enhanced gait complexity in the regular exercisers may indicate that ongoing exercise is a key ingredient contributing to health in persons with Parkinson's disease. Exercising on a regular basis with Parkinson's disease may augment one's ability to adapt to barriers encountered during gait regardless of medication state.
•Gait complexity is greater in exercisers regardless of being ON or OFF medications.•Persons with Parkinson's who exercise have better capacity to adapt their gait.•Anti-Parkinson medications did not alter gait complexity in regular exercisers.•Anti-Parkinson medications improved gait complexity in non-exercisers.</description><identifier>ISSN: 0268-0033</identifier><identifier>EISSN: 1879-1271</identifier><identifier>DOI: 10.1016/j.clinbiomech.2019.05.032</identifier><identifier>PMID: 31146080</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antiparkinson agents ; Boxing ; Entropy ; Exercise ; Parkinson's disease</subject><ispartof>Clinical biomechanics (Bristol), 2019-08, Vol.68, p.23-28</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-c304ab0e6dc630b47433c8ae89ed595945f74bf0cdc8e26e546788b82495ca233</citedby><cites>FETCH-LOGICAL-c377t-c304ab0e6dc630b47433c8ae89ed595945f74bf0cdc8e26e546788b82495ca233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0268003318308192$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31146080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Combs-Miller, Stephanie A.</creatorcontrib><creatorcontrib>Dugan, Eric L.</creatorcontrib><creatorcontrib>Beachy, Ann</creatorcontrib><creatorcontrib>Derby, Brook B.</creatorcontrib><creatorcontrib>Hosinski, Alicia L.</creatorcontrib><creatorcontrib>Robbins, Kristen</creatorcontrib><title>Physiological complexity of gait between regular and non-exercisers with Parkinson's disease</title><title>Clinical biomechanics (Bristol)</title><addtitle>Clin Biomech (Bristol, Avon)</addtitle><description>Physiological complexity represents overall health of a system and its underlying capacity to adapt to stresses. The primary purpose of this study was to determine if physiological complexity of gait both ON and OFF anti-Parkinson medication differed between regular and non-exercisers with Parkinson's disease.
Twenty participants with idiopathic Parkinson's disease were enrolled in this cross-sectional study (regular exercisers n = 10, non-exercisers n = 10). Two data collection sessions were completed during a single visit, first after a 12-hour overnight withdrawal from anti-Parkinson medications (OFF), and again one-hour after taking anti-Parkinson medications (ON). During each session participants completed a 2-minute walking task at their preferred pace while wearing wireless inertial measurement units on each lower extremity segment (thigh, shank, foot). Multivariate multiscale entropy was calculated from the tri-axial accelerometer signals and converted to a complexity index for analysis.
Regular exercisers demonstrated significantly higher complexity indices ON and OFF anti-Parkinson medications compared to non-exercisers (ON F = 3.84 P = 0.02; OFF F = 3.61, P < 0.03). Regular exercisers did not significantly differ in complexity between OFF and ON states (most affected leg F = 0.15 P = 0.71; least affected leg F = 0.30 P = 0.60), but non-exercisers demonstrated significantly decreased complexity in the least affected leg OFF anti-Parkinson medications (F = 5.17 P < 0.04).
Enhanced gait complexity in the regular exercisers may indicate that ongoing exercise is a key ingredient contributing to health in persons with Parkinson's disease. Exercising on a regular basis with Parkinson's disease may augment one's ability to adapt to barriers encountered during gait regardless of medication state.
•Gait complexity is greater in exercisers regardless of being ON or OFF medications.•Persons with Parkinson's who exercise have better capacity to adapt their gait.•Anti-Parkinson medications did not alter gait complexity in regular exercisers.•Anti-Parkinson medications improved gait complexity in non-exercisers.</description><subject>Antiparkinson agents</subject><subject>Boxing</subject><subject>Entropy</subject><subject>Exercise</subject><subject>Parkinson's disease</subject><issn>0268-0033</issn><issn>1879-1271</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNkE1v1DAQhi1ERZfCX0DmBJeE8VfsHNGKL6kSPbS3SpbjTHa9JPZiZ2n335PVFsSRy4w0et4ZzUPIWwY1A9Z82NV-DLELaUK_rTmwtgZVg-DPyIoZ3VaMa_acrIA3pgIQ4pK8LGUHAJIr_YJcCsZkAwZW5P5meywhjWkTvBupT9N-xMcwH2ka6MaFmXY4PyBGmnFzGF2mLvY0pljhI2YfCuZCH8K8pTcu_wixpPiu0H6Zu4KvyMXgxoKvn_oVufv86Xb9tbr-_uXb-uN15YXW81JBug6w6X0joJNaCuGNQ9Nir1rVSjVo2Q3ge2-QN6hko43pDJet8o4LcUXen_fuc_p5wDLbKRSP4-gipkOxfGGM0qw5oe0Z9TmVknGw-xwml4-WgT3JtTv7j1x7kmtB2UXukn3zdObQTdj_Tf6xuQDrM4DLs78CZlt8wOixDxn9bPsU_uPMbxahkiw</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Combs-Miller, Stephanie A.</creator><creator>Dugan, Eric L.</creator><creator>Beachy, Ann</creator><creator>Derby, Brook B.</creator><creator>Hosinski, Alicia L.</creator><creator>Robbins, Kristen</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201908</creationdate><title>Physiological complexity of gait between regular and non-exercisers with Parkinson's disease</title><author>Combs-Miller, Stephanie A. ; Dugan, Eric L. ; Beachy, Ann ; Derby, Brook B. ; Hosinski, Alicia L. ; Robbins, Kristen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-c304ab0e6dc630b47433c8ae89ed595945f74bf0cdc8e26e546788b82495ca233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antiparkinson agents</topic><topic>Boxing</topic><topic>Entropy</topic><topic>Exercise</topic><topic>Parkinson's disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Combs-Miller, Stephanie A.</creatorcontrib><creatorcontrib>Dugan, Eric L.</creatorcontrib><creatorcontrib>Beachy, Ann</creatorcontrib><creatorcontrib>Derby, Brook B.</creatorcontrib><creatorcontrib>Hosinski, Alicia L.</creatorcontrib><creatorcontrib>Robbins, Kristen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biomechanics (Bristol)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Combs-Miller, Stephanie A.</au><au>Dugan, Eric L.</au><au>Beachy, Ann</au><au>Derby, Brook B.</au><au>Hosinski, Alicia L.</au><au>Robbins, Kristen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physiological complexity of gait between regular and non-exercisers with Parkinson's disease</atitle><jtitle>Clinical biomechanics (Bristol)</jtitle><addtitle>Clin Biomech (Bristol, Avon)</addtitle><date>2019-08</date><risdate>2019</risdate><volume>68</volume><spage>23</spage><epage>28</epage><pages>23-28</pages><issn>0268-0033</issn><eissn>1879-1271</eissn><abstract>Physiological complexity represents overall health of a system and its underlying capacity to adapt to stresses. The primary purpose of this study was to determine if physiological complexity of gait both ON and OFF anti-Parkinson medication differed between regular and non-exercisers with Parkinson's disease.
Twenty participants with idiopathic Parkinson's disease were enrolled in this cross-sectional study (regular exercisers n = 10, non-exercisers n = 10). Two data collection sessions were completed during a single visit, first after a 12-hour overnight withdrawal from anti-Parkinson medications (OFF), and again one-hour after taking anti-Parkinson medications (ON). During each session participants completed a 2-minute walking task at their preferred pace while wearing wireless inertial measurement units on each lower extremity segment (thigh, shank, foot). Multivariate multiscale entropy was calculated from the tri-axial accelerometer signals and converted to a complexity index for analysis.
Regular exercisers demonstrated significantly higher complexity indices ON and OFF anti-Parkinson medications compared to non-exercisers (ON F = 3.84 P = 0.02; OFF F = 3.61, P < 0.03). Regular exercisers did not significantly differ in complexity between OFF and ON states (most affected leg F = 0.15 P = 0.71; least affected leg F = 0.30 P = 0.60), but non-exercisers demonstrated significantly decreased complexity in the least affected leg OFF anti-Parkinson medications (F = 5.17 P < 0.04).
Enhanced gait complexity in the regular exercisers may indicate that ongoing exercise is a key ingredient contributing to health in persons with Parkinson's disease. Exercising on a regular basis with Parkinson's disease may augment one's ability to adapt to barriers encountered during gait regardless of medication state.
•Gait complexity is greater in exercisers regardless of being ON or OFF medications.•Persons with Parkinson's who exercise have better capacity to adapt their gait.•Anti-Parkinson medications did not alter gait complexity in regular exercisers.•Anti-Parkinson medications improved gait complexity in non-exercisers.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31146080</pmid><doi>10.1016/j.clinbiomech.2019.05.032</doi><tpages>6</tpages></addata></record> |
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| subjects | Antiparkinson agents Boxing Entropy Exercise Parkinson's disease |
| title | Physiological complexity of gait between regular and non-exercisers with Parkinson's disease |
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