Dehydrocostus lactone suppresses osteoclast differentiation by regulating NFATc1 and inhibits osteoclast activation through modulating migration and lysosome function

ABSTRACT Excessive osteoclast activity can lead to an imbalance between the synthesis and breakdown of bone, with pathologic consequences that include osteoporosis and periodontitis. Thus, controlling osteoclast differentiation and function has significant therapeutic implications. In this study, we...

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Veröffentlicht in:	The FASEB journal 2019-08, Vol.33 (8), p.9685-9694
Hauptverfasser:	Lee, Hye In, Lee, Jiae, Hwang, Donghyun, Lee, Gong‐Rak, Kim, Narae, Kwon, Minjeong, Lee, Hana, Piao, Donglan, Kim, Hyun Jin, Kim, Nam Young, Kim, Han Sung, Seo, Eun Kyoung, Kang, Dongmin, Jeong, Woojin
Format:	Artikel
Sprache:	eng
Schlagworte:	Atg5 bone integrin PKC‐β
Online-Zugang:	Volltext
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