IRF2BP2 modulates the crosstalk between glucocorticoid and TNF signaling

IRF2BP2 (interferon regulatory factor-2 binding protein-2) is an uncharacterized interaction partner of glucocorticoid (GC) receptor (GR), an anti-inflammatory and metabolic transcription factor. Here, we show that GC changes the chromatin binding of IRF2BP2 in natural chromatin milieu. The GC-induc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2019-09, Vol.192, p.105382-105382, Article 105382
Hauptverfasser:	Manjur, A.B.M. Kaiser, Lempiäinen, Joanna K., Malinen, Marjo, Palvimo, Jorma J., Niskanen, Einari A.
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Anti-Inflammatory Agents - pharmacology Binding sites Cell Movement Cell Proliferation Chromatin Dexamethasone DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation - drug effects Glucocorticoid receptor (GR) Glucocorticoids Glucocorticoids - pharmacology HEK293 Cells Humans Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Interferon Interferon regulatory factor Interferon regulatory factor-2 binding protein-2 (IRF2BP2) Metabolism NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Nuclear factor-κB (NF-κB) Transcription Factors - genetics Transcription Factors - metabolism Tumor necrosis factor α (TNF) Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF Tumor necrosis factor-α
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!