Management of seizures in patients with multiple sclerosis; an Iranian consensus

Cooccurrence of a seizure in a patient with multiple sclerosis (MS) may complicate the management process. Questions, which may complicate the management process of a patient with MS and seizure, include “how should we approach to the patient”, “how should we treat the patient”, “how should we modify the patient's MS treatment strategy”, etc. We searched the electronic database PubMed on March 30, 2018 for articles in English that included the following search terms: “epilepsy” AND “multiple sclerosis” or “seizure” AND “multiple sclerosis” since 2013, to obtain the best recent relevant scientific evidence on the topic. A working group of 6 epilepsy and 5 MS experts took part in two consensus workshops in Tehran, Iran, in 2018. The final consensus manuscript was prepared and approved by all participants. The search with words “seizure” and “multiple sclerosis” yielded 121 entries; 10 were relevant to the topic. The search with words “epilepsy” and “multiple sclerosis” yielded 400 entries; 7 were relevant to the topic. We reviewed these 17 articles and also some other references, derived from these articles or relevant to the topic, for the purpose of our review. Cooccurrence of a seizure in a patient with MS may complicate the management process. In this review, we tried to provide answers to the frequently asked questions, considering the best available scientific evidence and expert opinion. •Cooccurrence of a seizure in a patient with MS may complicate the management process.•The objective of our endeavor was to reach to a consensus on how to manage seizure(s) in patients with MS.•We reviewed these 17 articles and also some other references for the purpose of our review.