Controlling distinct signaling states in cultured cancer cells provides a new platform for drug discovery

ABSTRACT Cancer cells can switch between signaling pathways to regulate growth under different conditions. In the tumor microenvironment, this likely helps them evade therapies that target specific pathways. We must identify all possible states and utilize them in drug screening programs. One such s...

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Veröffentlicht in:The FASEB journal 2019-08, Vol.33 (8), p.9235-9249
Hauptverfasser: Poser, Steven W., Otto, Oliver, Arps‐Forker, Carina, Ge, Yan, Herbig, Maik, Andree, Cordula, Gruetzmann, Konrad, Adasme, Melissa F., Stodolak, Szymon, Nikolakopoulou, Polyxeni, Park, Deric M., Mcintyre, Alan, Lesche, Mathias, Dahl, Andreas, Lennig, Petra, Bornstein, Stefan R., Schroeck, Evelin, Klink, Barbara, Leker, Ronen R., Bickle, Marc, Chrousos, George P., Schroeder, Michael, Cannistraci, Carlo Vittorio, Guck, Jochen, Androutsellis‐Theotokis, Andreas
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Sprache:eng
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