Changes in medication adherence and unused drugs after switching from daily dipeptidyl peptidase-4 inhibitors to once-weekly trelagliptin in patients with type 2 diabetes
The changes in patients’ satisfaction with the treatment, medication adherence and unused drugs before and after switching from daily DPP-4 inhibitors to once-weekly trelagliptin administration were prospectively investigated in patients with type 2 diabetes. After excluding 46 patients who declined...
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| Veröffentlicht in: | Diabetes research and clinical practice 2019-07, Vol.153, p.41-48 |
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| creator | Ito, Hiroyuki Ando, Shigenori Tsugami, Emiko Araki, Rie Kusano, Eiji Matsumoto, Suzuko Uemura, Kosuke Nishio, Shinya Antoku, Shinichi Yamasaki, Tomoko Mori, Toshiko Togane, Michiko |
| description | The changes in patients’ satisfaction with the treatment, medication adherence and unused drugs before and after switching from daily DPP-4 inhibitors to once-weekly trelagliptin administration were prospectively investigated in patients with type 2 diabetes.
After excluding 46 patients who declined to switch from daily DPP-4 inhibitors, 79 subjects were included in the present study. The clinical parameters and results of questionnaire surveys regarding satisfaction with treatment as well as impressions of the amount of medicine/number of doses, medication adherence, and unused drug were examined at the baseline and 3 months after switching from daily DPP-4 inhibitors to trelagliptin in 75 patients with type 2 diabetes.
Although the value of HbA1c did not change (7.0% ± 0.5% to 7.0% ± 0.6%), the scores representing satisfaction with the treatment (25.2 ± 6.4 to 26.4 ± 6.0), impression of the amount of medicine (−0.3 ± 1.0 to 0.3 ± 1.0) and number of doses (0.3 ± 1.0 to 0.8 ± 0.6), and medication adherence (0.8 ± 0.4 to 0.9 ± 0.3) as assessed by the questionnaire surveys were significantly improved after switching from DPP-4 inhibitors. The self-reported amount of unused drugs was significantly reduced after switching.
Switching from daily DPP-4 inhibitors to once-weekly trelagliptin improved the satisfaction with the treatment, impression of the prescribed medicine and medication adherence in the type 2 diabetic patients who expresses a desire to reduce their prescription medicines. In such patients, improvements in the glycemic control and long-term prognosis might be expected through the reduction of unused drugs. |
| doi_str_mv | 10.1016/j.diabres.2019.05.025 |
| format | Article |
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After excluding 46 patients who declined to switch from daily DPP-4 inhibitors, 79 subjects were included in the present study. The clinical parameters and results of questionnaire surveys regarding satisfaction with treatment as well as impressions of the amount of medicine/number of doses, medication adherence, and unused drug were examined at the baseline and 3 months after switching from daily DPP-4 inhibitors to trelagliptin in 75 patients with type 2 diabetes.
Although the value of HbA1c did not change (7.0% ± 0.5% to 7.0% ± 0.6%), the scores representing satisfaction with the treatment (25.2 ± 6.4 to 26.4 ± 6.0), impression of the amount of medicine (−0.3 ± 1.0 to 0.3 ± 1.0) and number of doses (0.3 ± 1.0 to 0.8 ± 0.6), and medication adherence (0.8 ± 0.4 to 0.9 ± 0.3) as assessed by the questionnaire surveys were significantly improved after switching from DPP-4 inhibitors. The self-reported amount of unused drugs was significantly reduced after switching.
Switching from daily DPP-4 inhibitors to once-weekly trelagliptin improved the satisfaction with the treatment, impression of the prescribed medicine and medication adherence in the type 2 diabetic patients who expresses a desire to reduce their prescription medicines. In such patients, improvements in the glycemic control and long-term prognosis might be expected through the reduction of unused drugs.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2019.05.025</identifier><identifier>PMID: 31150724</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adherence ; DPP-4 inhibitor ; Once-weekly ; Treatment satisfaction ; Trelagliptin ; Unused drug</subject><ispartof>Diabetes research and clinical practice, 2019-07, Vol.153, p.41-48</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-da15da3a0b2f6a1a79bb1843b8ca983d56b0d1f5b60684f146dfef2476ce31f73</citedby><cites>FETCH-LOGICAL-c365t-da15da3a0b2f6a1a79bb1843b8ca983d56b0d1f5b60684f146dfef2476ce31f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168822719305959$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31150724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Hiroyuki</creatorcontrib><creatorcontrib>Ando, Shigenori</creatorcontrib><creatorcontrib>Tsugami, Emiko</creatorcontrib><creatorcontrib>Araki, Rie</creatorcontrib><creatorcontrib>Kusano, Eiji</creatorcontrib><creatorcontrib>Matsumoto, Suzuko</creatorcontrib><creatorcontrib>Uemura, Kosuke</creatorcontrib><creatorcontrib>Nishio, Shinya</creatorcontrib><creatorcontrib>Antoku, Shinichi</creatorcontrib><creatorcontrib>Yamasaki, Tomoko</creatorcontrib><creatorcontrib>Mori, Toshiko</creatorcontrib><creatorcontrib>Togane, Michiko</creatorcontrib><title>Changes in medication adherence and unused drugs after switching from daily dipeptidyl peptidase-4 inhibitors to once-weekly trelagliptin in patients with type 2 diabetes</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>The changes in patients’ satisfaction with the treatment, medication adherence and unused drugs before and after switching from daily DPP-4 inhibitors to once-weekly trelagliptin administration were prospectively investigated in patients with type 2 diabetes.
After excluding 46 patients who declined to switch from daily DPP-4 inhibitors, 79 subjects were included in the present study. The clinical parameters and results of questionnaire surveys regarding satisfaction with treatment as well as impressions of the amount of medicine/number of doses, medication adherence, and unused drug were examined at the baseline and 3 months after switching from daily DPP-4 inhibitors to trelagliptin in 75 patients with type 2 diabetes.
Although the value of HbA1c did not change (7.0% ± 0.5% to 7.0% ± 0.6%), the scores representing satisfaction with the treatment (25.2 ± 6.4 to 26.4 ± 6.0), impression of the amount of medicine (−0.3 ± 1.0 to 0.3 ± 1.0) and number of doses (0.3 ± 1.0 to 0.8 ± 0.6), and medication adherence (0.8 ± 0.4 to 0.9 ± 0.3) as assessed by the questionnaire surveys were significantly improved after switching from DPP-4 inhibitors. The self-reported amount of unused drugs was significantly reduced after switching.
Switching from daily DPP-4 inhibitors to once-weekly trelagliptin improved the satisfaction with the treatment, impression of the prescribed medicine and medication adherence in the type 2 diabetic patients who expresses a desire to reduce their prescription medicines. In such patients, improvements in the glycemic control and long-term prognosis might be expected through the reduction of unused drugs.</description><subject>Adherence</subject><subject>DPP-4 inhibitor</subject><subject>Once-weekly</subject><subject>Treatment satisfaction</subject><subject>Trelagliptin</subject><subject>Unused drug</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAUhS0EotPCI4C8ZJPgnzjxrBAa0VKpUjewthz7euIh4wTboZpX6lPiMANbVr6L75zjew9C7yipKaHtx0Ntve4jpJoRuq2JqAkTL9CGyo5VkrHuJdoUTv6Zr9B1SgdCSMsb8RpdcUoF6VizQc-7QYc9JOwDPoL1Rmc_BaztABGCAayDxUtYElhs47JPWLsMEacnn83gwx67OB2x1X48YetnmLO3pxGfB52gaor14Hufp5hwnvBUXKsngB9FkCOMej_6wob1B3NJh5ATLu4DzqcZMMPrnpAhvUGvnB4TvL28N-j77Zdvu6_Vw-Pd_e7zQ2V4K3JlNRVWc0165lpNdbfteyob3kujt5Jb0fbEUif6lrSycbRprQPHmq41wKnr-A36cPad4_RzgZTV0ScD46gDTEtSjHEuBZONLKg4oyZOKUVwao7-qONJUaLWmtRBXWpSa02KCFVqKrr3l4ilL1f_p_rbSwE-nQEoi_7yEFUyfu3D-ggmKzv5_0T8BhSZqug</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Ito, Hiroyuki</creator><creator>Ando, Shigenori</creator><creator>Tsugami, Emiko</creator><creator>Araki, Rie</creator><creator>Kusano, Eiji</creator><creator>Matsumoto, Suzuko</creator><creator>Uemura, Kosuke</creator><creator>Nishio, Shinya</creator><creator>Antoku, Shinichi</creator><creator>Yamasaki, Tomoko</creator><creator>Mori, Toshiko</creator><creator>Togane, Michiko</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190701</creationdate><title>Changes in medication adherence and unused drugs after switching from daily dipeptidyl peptidase-4 inhibitors to once-weekly trelagliptin in patients with type 2 diabetes</title><author>Ito, Hiroyuki ; Ando, Shigenori ; Tsugami, Emiko ; Araki, Rie ; Kusano, Eiji ; Matsumoto, Suzuko ; Uemura, Kosuke ; Nishio, Shinya ; Antoku, Shinichi ; Yamasaki, Tomoko ; Mori, Toshiko ; Togane, Michiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-da15da3a0b2f6a1a79bb1843b8ca983d56b0d1f5b60684f146dfef2476ce31f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adherence</topic><topic>DPP-4 inhibitor</topic><topic>Once-weekly</topic><topic>Treatment satisfaction</topic><topic>Trelagliptin</topic><topic>Unused drug</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Hiroyuki</creatorcontrib><creatorcontrib>Ando, Shigenori</creatorcontrib><creatorcontrib>Tsugami, Emiko</creatorcontrib><creatorcontrib>Araki, Rie</creatorcontrib><creatorcontrib>Kusano, Eiji</creatorcontrib><creatorcontrib>Matsumoto, Suzuko</creatorcontrib><creatorcontrib>Uemura, Kosuke</creatorcontrib><creatorcontrib>Nishio, Shinya</creatorcontrib><creatorcontrib>Antoku, Shinichi</creatorcontrib><creatorcontrib>Yamasaki, Tomoko</creatorcontrib><creatorcontrib>Mori, Toshiko</creatorcontrib><creatorcontrib>Togane, Michiko</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Hiroyuki</au><au>Ando, Shigenori</au><au>Tsugami, Emiko</au><au>Araki, Rie</au><au>Kusano, Eiji</au><au>Matsumoto, Suzuko</au><au>Uemura, Kosuke</au><au>Nishio, Shinya</au><au>Antoku, Shinichi</au><au>Yamasaki, Tomoko</au><au>Mori, Toshiko</au><au>Togane, Michiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in medication adherence and unused drugs after switching from daily dipeptidyl peptidase-4 inhibitors to once-weekly trelagliptin in patients with type 2 diabetes</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>153</volume><spage>41</spage><epage>48</epage><pages>41-48</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>The changes in patients’ satisfaction with the treatment, medication adherence and unused drugs before and after switching from daily DPP-4 inhibitors to once-weekly trelagliptin administration were prospectively investigated in patients with type 2 diabetes.
After excluding 46 patients who declined to switch from daily DPP-4 inhibitors, 79 subjects were included in the present study. The clinical parameters and results of questionnaire surveys regarding satisfaction with treatment as well as impressions of the amount of medicine/number of doses, medication adherence, and unused drug were examined at the baseline and 3 months after switching from daily DPP-4 inhibitors to trelagliptin in 75 patients with type 2 diabetes.
Although the value of HbA1c did not change (7.0% ± 0.5% to 7.0% ± 0.6%), the scores representing satisfaction with the treatment (25.2 ± 6.4 to 26.4 ± 6.0), impression of the amount of medicine (−0.3 ± 1.0 to 0.3 ± 1.0) and number of doses (0.3 ± 1.0 to 0.8 ± 0.6), and medication adherence (0.8 ± 0.4 to 0.9 ± 0.3) as assessed by the questionnaire surveys were significantly improved after switching from DPP-4 inhibitors. The self-reported amount of unused drugs was significantly reduced after switching.
Switching from daily DPP-4 inhibitors to once-weekly trelagliptin improved the satisfaction with the treatment, impression of the prescribed medicine and medication adherence in the type 2 diabetic patients who expresses a desire to reduce their prescription medicines. In such patients, improvements in the glycemic control and long-term prognosis might be expected through the reduction of unused drugs.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>31150724</pmid><doi>10.1016/j.diabres.2019.05.025</doi><tpages>8</tpages></addata></record> |
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| subjects | Adherence DPP-4 inhibitor Once-weekly Treatment satisfaction Trelagliptin Unused drug |
| title | Changes in medication adherence and unused drugs after switching from daily dipeptidyl peptidase-4 inhibitors to once-weekly trelagliptin in patients with type 2 diabetes |
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