Histone Deacetylase Inhibition with Panobinostat Combined with Intensive Induction Chemotherapy in Older Patients with Acute Myeloid Leukemia: Phase I Study Results

The histone deacetylase (HDAC) inhibitor panobinostat potentiates anthracycline and cytarabine cytotoxicity in acute myeloid leukemia (AML) cells. We hypothesized that panobinostat prior to and during induction chemotherapy would be tolerable and augment response in patients showing increased histon...

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Veröffentlicht in:	Clinical cancer research 2019-08, Vol.25 (16), p.4917-4923
Hauptverfasser:	Wieduwilt, Matthew J, Pawlowska, Nela, Thomas, Scott, Olin, Rebecca, Logan, Aaron C, Damon, Lloyd E, Martin, Thomas, Kang, McNancy, Sayre, Peter H, Boyer, Wanda, Gaensler, Karin M L, Anderson, Kirsten, Munster, Pamela N, Andreadis, Charalambos
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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