Changes in the diet composition of fatty acids and fiber affect the lower gastrointestinal motility but have no impact on cardiovascular parameters: In vivo and in vitro studies
Background Food and diet are central issues for proper functioning of the cardiovascular (CV) system and gastrointestinal (GI) tract. We hypothesize that different types of dietary FAs affect CV parameters as well as GI motor function and visceral sensitivity. Methods Male Wistar rats were fed with...
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| Veröffentlicht in: | Neurogastroenterology and motility 2019-09, Vol.31 (9), p.e13651-n/a |
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| creator | Mosińska, Paula Martín‐Ruiz, Marta González, Antonio López‐Miranda, Visitación Herradón, Esperanza Uranga, José A. Vera, Gema Sánchez‐Yáñez, Adrián Martín‐Fontelles, Mª Isabel Fichna, Jakub Abalo, Raquel |
| description | Background
Food and diet are central issues for proper functioning of the cardiovascular (CV) system and gastrointestinal (GI) tract. We hypothesize that different types of dietary FAs affect CV parameters as well as GI motor function and visceral sensitivity.
Methods
Male Wistar rats were fed with control diet (CTRL), diet supplemented with 7% soybean oil (SOY), SOY + 3.5% virgin coconut oil (COCO), and SOY + 3.5% evening primrose oil (EP) for 4 weeks. The content of insoluble fiber in CTRL was higher than in SOY, COCO, or EP. Body weight gain and food/water intake were measured. At day 28, biometric, biochemical, CV parameters, GI motor function (X‐ray and colon bead expulsion test), and visceral sensitivity were evaluated. Changes in propulsive colonic activity were determined in vitro. The colon and adipose tissue were histologically studied; the number of mast cells (MCs) in the colon was calculated.
Results
SOY, COCO, and EP had increased body weight gain but decreased food intake vs CTRL. Water consumption, biometric, biochemical, and CV parameters were comparable between groups. SOY increased the sensitivity to colonic distention. All groups maintained regular propulsive neurogenic contractions; EP delayed colonic motility (P |
| doi_str_mv | 10.1111/nmo.13651 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2232478280</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2272646330</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3531-20d3490cfa4a4b70319e31d72916f40ec8a6a69996db2820c3d72dc133c0d96d3</originalsourceid><addsrcrecordid>eNp1kctu1DAUhi0EohdY8ALoSGxgkdaXJJOwq0ZQKpV2U9bRiS8dV4kdbGeqeSzeEGemsKhUb87R8ff_vvyEfGD0jOV17kZ_xkRdsVfkeKkFbxv-eukrWrCWV0fkJMYHSmnNy_otORKMlVUlmmPyZ71Bd68jWAdpo0FZnUD6cfLRJusdeAMGU9oBSqsioFNgbK8DoDFapr1o8I95cI8xBW9d0jFZhwOMPtnBZmk_J9jgVoPzYMcJsyw7SwzK-i1GOQ8YYMKAo046xK9w5WBrt35_ml36bAwxzfl28R15Y3CI-v1TPSW_vn-7W_8orm8vr9YX14UUlWAFp0qULZUGSyz7FRWs1YKpFW9ZbUqqZYM11m3b1qrnDadS5D0lmRCSqjwUp-TzwXcK_vec39SNNko9DOi0n2PHueDlquENzeinZ-iDn0P-goVa8bqshVioLwdKBh9j0Kabgh0x7DpGuyXHLufY7XPM7Mcnx7kftfpP_gsuA-cH4NEOeveyU3fz8_Zg-ReMcamV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2272646330</pqid></control><display><type>article</type><title>Changes in the diet composition of fatty acids and fiber affect the lower gastrointestinal motility but have no impact on cardiovascular parameters: In vivo and in vitro studies</title><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><creator>Mosińska, Paula ; Martín‐Ruiz, Marta ; González, Antonio ; López‐Miranda, Visitación ; Herradón, Esperanza ; Uranga, José A. ; Vera, Gema ; Sánchez‐Yáñez, Adrián ; Martín‐Fontelles, Mª Isabel ; Fichna, Jakub ; Abalo, Raquel</creator><creatorcontrib>Mosińska, Paula ; Martín‐Ruiz, Marta ; González, Antonio ; López‐Miranda, Visitación ; Herradón, Esperanza ; Uranga, José A. ; Vera, Gema ; Sánchez‐Yáñez, Adrián ; Martín‐Fontelles, Mª Isabel ; Fichna, Jakub ; Abalo, Raquel</creatorcontrib><description>Background
Food and diet are central issues for proper functioning of the cardiovascular (CV) system and gastrointestinal (GI) tract. We hypothesize that different types of dietary FAs affect CV parameters as well as GI motor function and visceral sensitivity.
Methods
Male Wistar rats were fed with control diet (CTRL), diet supplemented with 7% soybean oil (SOY), SOY + 3.5% virgin coconut oil (COCO), and SOY + 3.5% evening primrose oil (EP) for 4 weeks. The content of insoluble fiber in CTRL was higher than in SOY, COCO, or EP. Body weight gain and food/water intake were measured. At day 28, biometric, biochemical, CV parameters, GI motor function (X‐ray and colon bead expulsion test), and visceral sensitivity were evaluated. Changes in propulsive colonic activity were determined in vitro. The colon and adipose tissue were histologically studied; the number of mast cells (MCs) in the colon was calculated.
Results
SOY, COCO, and EP had increased body weight gain but decreased food intake vs CTRL. Water consumption, biometric, biochemical, and CV parameters were comparable between groups. SOY increased the sensitivity to colonic distention. All groups maintained regular propulsive neurogenic contractions; EP delayed colonic motility (P < 0.01). SOY, COCO, and EP displayed decreased size of the cecum, lower number and size of fecal pellets, and higher infiltration of MCs to the colon (P < 0.001).
Conclusions and Inferences
Dietary FAs supplementation and lower intake of insoluble fiber can induce changes in the motility of the lower GI tract, in vivo and in vitro, but CV function and visceral sensitivity are not generally affected.
In this manuscript, we show that short‐term changes in dietary fatty acids and fiber content modify colonic motor function and, to a lesser extent, pain perception without much affecting upper gastrointestinal transit or CV parameters. Some of the effects depend on fiber content, and some others depend on the chain length and type of FAs consumed.</description><identifier>ISSN: 1350-1925</identifier><identifier>EISSN: 1365-2982</identifier><identifier>DOI: 10.1111/nmo.13651</identifier><identifier>PMID: 31145538</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adipose tissue ; Biometrics ; Body weight gain ; cardiovascular parameters ; Cecum ; Coconut oil ; Colon ; Diet ; Dietary fiber ; Dietary intake ; Dietary supplements ; Fatty acids ; Food intake ; Gastric motility ; gastrointestinal motility ; Gastrointestinal tract ; long‐chain fatty acids ; Mast cells ; medium‐chain fatty acids ; Motility ; nutrition ; Soybeans ; Vegetable oils ; Water intake</subject><ispartof>Neurogastroenterology and motility, 2019-09, Vol.31 (9), p.e13651-n/a</ispartof><rights>2019 John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-20d3490cfa4a4b70319e31d72916f40ec8a6a69996db2820c3d72dc133c0d96d3</citedby><cites>FETCH-LOGICAL-c3531-20d3490cfa4a4b70319e31d72916f40ec8a6a69996db2820c3d72dc133c0d96d3</cites><orcidid>0000-0002-8443-4417 ; 0000-0003-0711-8979 ; 0000-0002-6726-8795 ; 0000-0002-1838-0975 ; 0000-0003-4656-8569 ; 0000-0001-8831-3754</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnmo.13651$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnmo.13651$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31145538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mosińska, Paula</creatorcontrib><creatorcontrib>Martín‐Ruiz, Marta</creatorcontrib><creatorcontrib>González, Antonio</creatorcontrib><creatorcontrib>López‐Miranda, Visitación</creatorcontrib><creatorcontrib>Herradón, Esperanza</creatorcontrib><creatorcontrib>Uranga, José A.</creatorcontrib><creatorcontrib>Vera, Gema</creatorcontrib><creatorcontrib>Sánchez‐Yáñez, Adrián</creatorcontrib><creatorcontrib>Martín‐Fontelles, Mª Isabel</creatorcontrib><creatorcontrib>Fichna, Jakub</creatorcontrib><creatorcontrib>Abalo, Raquel</creatorcontrib><title>Changes in the diet composition of fatty acids and fiber affect the lower gastrointestinal motility but have no impact on cardiovascular parameters: In vivo and in vitro studies</title><title>Neurogastroenterology and motility</title><addtitle>Neurogastroenterol Motil</addtitle><description>Background
Food and diet are central issues for proper functioning of the cardiovascular (CV) system and gastrointestinal (GI) tract. We hypothesize that different types of dietary FAs affect CV parameters as well as GI motor function and visceral sensitivity.
Methods
Male Wistar rats were fed with control diet (CTRL), diet supplemented with 7% soybean oil (SOY), SOY + 3.5% virgin coconut oil (COCO), and SOY + 3.5% evening primrose oil (EP) for 4 weeks. The content of insoluble fiber in CTRL was higher than in SOY, COCO, or EP. Body weight gain and food/water intake were measured. At day 28, biometric, biochemical, CV parameters, GI motor function (X‐ray and colon bead expulsion test), and visceral sensitivity were evaluated. Changes in propulsive colonic activity were determined in vitro. The colon and adipose tissue were histologically studied; the number of mast cells (MCs) in the colon was calculated.
Results
SOY, COCO, and EP had increased body weight gain but decreased food intake vs CTRL. Water consumption, biometric, biochemical, and CV parameters were comparable between groups. SOY increased the sensitivity to colonic distention. All groups maintained regular propulsive neurogenic contractions; EP delayed colonic motility (P < 0.01). SOY, COCO, and EP displayed decreased size of the cecum, lower number and size of fecal pellets, and higher infiltration of MCs to the colon (P < 0.001).
Conclusions and Inferences
Dietary FAs supplementation and lower intake of insoluble fiber can induce changes in the motility of the lower GI tract, in vivo and in vitro, but CV function and visceral sensitivity are not generally affected.
In this manuscript, we show that short‐term changes in dietary fatty acids and fiber content modify colonic motor function and, to a lesser extent, pain perception without much affecting upper gastrointestinal transit or CV parameters. Some of the effects depend on fiber content, and some others depend on the chain length and type of FAs consumed.</description><subject>Adipose tissue</subject><subject>Biometrics</subject><subject>Body weight gain</subject><subject>cardiovascular parameters</subject><subject>Cecum</subject><subject>Coconut oil</subject><subject>Colon</subject><subject>Diet</subject><subject>Dietary fiber</subject><subject>Dietary intake</subject><subject>Dietary supplements</subject><subject>Fatty acids</subject><subject>Food intake</subject><subject>Gastric motility</subject><subject>gastrointestinal motility</subject><subject>Gastrointestinal tract</subject><subject>long‐chain fatty acids</subject><subject>Mast cells</subject><subject>medium‐chain fatty acids</subject><subject>Motility</subject><subject>nutrition</subject><subject>Soybeans</subject><subject>Vegetable oils</subject><subject>Water intake</subject><issn>1350-1925</issn><issn>1365-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kctu1DAUhi0EohdY8ALoSGxgkdaXJJOwq0ZQKpV2U9bRiS8dV4kdbGeqeSzeEGemsKhUb87R8ff_vvyEfGD0jOV17kZ_xkRdsVfkeKkFbxv-eukrWrCWV0fkJMYHSmnNy_otORKMlVUlmmPyZ71Bd68jWAdpo0FZnUD6cfLRJusdeAMGU9oBSqsioFNgbK8DoDFapr1o8I95cI8xBW9d0jFZhwOMPtnBZmk_J9jgVoPzYMcJsyw7SwzK-i1GOQ8YYMKAo046xK9w5WBrt35_ml36bAwxzfl28R15Y3CI-v1TPSW_vn-7W_8orm8vr9YX14UUlWAFp0qULZUGSyz7FRWs1YKpFW9ZbUqqZYM11m3b1qrnDadS5D0lmRCSqjwUp-TzwXcK_vec39SNNko9DOi0n2PHueDlquENzeinZ-iDn0P-goVa8bqshVioLwdKBh9j0Kabgh0x7DpGuyXHLufY7XPM7Mcnx7kftfpP_gsuA-cH4NEOeveyU3fz8_Zg-ReMcamV</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Mosińska, Paula</creator><creator>Martín‐Ruiz, Marta</creator><creator>González, Antonio</creator><creator>López‐Miranda, Visitación</creator><creator>Herradón, Esperanza</creator><creator>Uranga, José A.</creator><creator>Vera, Gema</creator><creator>Sánchez‐Yáñez, Adrián</creator><creator>Martín‐Fontelles, Mª Isabel</creator><creator>Fichna, Jakub</creator><creator>Abalo, Raquel</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8443-4417</orcidid><orcidid>https://orcid.org/0000-0003-0711-8979</orcidid><orcidid>https://orcid.org/0000-0002-6726-8795</orcidid><orcidid>https://orcid.org/0000-0002-1838-0975</orcidid><orcidid>https://orcid.org/0000-0003-4656-8569</orcidid><orcidid>https://orcid.org/0000-0001-8831-3754</orcidid></search><sort><creationdate>201909</creationdate><title>Changes in the diet composition of fatty acids and fiber affect the lower gastrointestinal motility but have no impact on cardiovascular parameters: In vivo and in vitro studies</title><author>Mosińska, Paula ; Martín‐Ruiz, Marta ; González, Antonio ; López‐Miranda, Visitación ; Herradón, Esperanza ; Uranga, José A. ; Vera, Gema ; Sánchez‐Yáñez, Adrián ; Martín‐Fontelles, Mª Isabel ; Fichna, Jakub ; Abalo, Raquel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-20d3490cfa4a4b70319e31d72916f40ec8a6a69996db2820c3d72dc133c0d96d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adipose tissue</topic><topic>Biometrics</topic><topic>Body weight gain</topic><topic>cardiovascular parameters</topic><topic>Cecum</topic><topic>Coconut oil</topic><topic>Colon</topic><topic>Diet</topic><topic>Dietary fiber</topic><topic>Dietary intake</topic><topic>Dietary supplements</topic><topic>Fatty acids</topic><topic>Food intake</topic><topic>Gastric motility</topic><topic>gastrointestinal motility</topic><topic>Gastrointestinal tract</topic><topic>long‐chain fatty acids</topic><topic>Mast cells</topic><topic>medium‐chain fatty acids</topic><topic>Motility</topic><topic>nutrition</topic><topic>Soybeans</topic><topic>Vegetable oils</topic><topic>Water intake</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mosińska, Paula</creatorcontrib><creatorcontrib>Martín‐Ruiz, Marta</creatorcontrib><creatorcontrib>González, Antonio</creatorcontrib><creatorcontrib>López‐Miranda, Visitación</creatorcontrib><creatorcontrib>Herradón, Esperanza</creatorcontrib><creatorcontrib>Uranga, José A.</creatorcontrib><creatorcontrib>Vera, Gema</creatorcontrib><creatorcontrib>Sánchez‐Yáñez, Adrián</creatorcontrib><creatorcontrib>Martín‐Fontelles, Mª Isabel</creatorcontrib><creatorcontrib>Fichna, Jakub</creatorcontrib><creatorcontrib>Abalo, Raquel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neurogastroenterology and motility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mosińska, Paula</au><au>Martín‐Ruiz, Marta</au><au>González, Antonio</au><au>López‐Miranda, Visitación</au><au>Herradón, Esperanza</au><au>Uranga, José A.</au><au>Vera, Gema</au><au>Sánchez‐Yáñez, Adrián</au><au>Martín‐Fontelles, Mª Isabel</au><au>Fichna, Jakub</au><au>Abalo, Raquel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in the diet composition of fatty acids and fiber affect the lower gastrointestinal motility but have no impact on cardiovascular parameters: In vivo and in vitro studies</atitle><jtitle>Neurogastroenterology and motility</jtitle><addtitle>Neurogastroenterol Motil</addtitle><date>2019-09</date><risdate>2019</risdate><volume>31</volume><issue>9</issue><spage>e13651</spage><epage>n/a</epage><pages>e13651-n/a</pages><issn>1350-1925</issn><eissn>1365-2982</eissn><abstract>Background
Food and diet are central issues for proper functioning of the cardiovascular (CV) system and gastrointestinal (GI) tract. We hypothesize that different types of dietary FAs affect CV parameters as well as GI motor function and visceral sensitivity.
Methods
Male Wistar rats were fed with control diet (CTRL), diet supplemented with 7% soybean oil (SOY), SOY + 3.5% virgin coconut oil (COCO), and SOY + 3.5% evening primrose oil (EP) for 4 weeks. The content of insoluble fiber in CTRL was higher than in SOY, COCO, or EP. Body weight gain and food/water intake were measured. At day 28, biometric, biochemical, CV parameters, GI motor function (X‐ray and colon bead expulsion test), and visceral sensitivity were evaluated. Changes in propulsive colonic activity were determined in vitro. The colon and adipose tissue were histologically studied; the number of mast cells (MCs) in the colon was calculated.
Results
SOY, COCO, and EP had increased body weight gain but decreased food intake vs CTRL. Water consumption, biometric, biochemical, and CV parameters were comparable between groups. SOY increased the sensitivity to colonic distention. All groups maintained regular propulsive neurogenic contractions; EP delayed colonic motility (P < 0.01). SOY, COCO, and EP displayed decreased size of the cecum, lower number and size of fecal pellets, and higher infiltration of MCs to the colon (P < 0.001).
Conclusions and Inferences
Dietary FAs supplementation and lower intake of insoluble fiber can induce changes in the motility of the lower GI tract, in vivo and in vitro, but CV function and visceral sensitivity are not generally affected.
In this manuscript, we show that short‐term changes in dietary fatty acids and fiber content modify colonic motor function and, to a lesser extent, pain perception without much affecting upper gastrointestinal transit or CV parameters. Some of the effects depend on fiber content, and some others depend on the chain length and type of FAs consumed.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31145538</pmid><doi>10.1111/nmo.13651</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-8443-4417</orcidid><orcidid>https://orcid.org/0000-0003-0711-8979</orcidid><orcidid>https://orcid.org/0000-0002-6726-8795</orcidid><orcidid>https://orcid.org/0000-0002-1838-0975</orcidid><orcidid>https://orcid.org/0000-0003-4656-8569</orcidid><orcidid>https://orcid.org/0000-0001-8831-3754</orcidid></addata></record> |
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| subjects | Adipose tissue Biometrics Body weight gain cardiovascular parameters Cecum Coconut oil Colon Diet Dietary fiber Dietary intake Dietary supplements Fatty acids Food intake Gastric motility gastrointestinal motility Gastrointestinal tract long‐chain fatty acids Mast cells medium‐chain fatty acids Motility nutrition Soybeans Vegetable oils Water intake |
| title | Changes in the diet composition of fatty acids and fiber affect the lower gastrointestinal motility but have no impact on cardiovascular parameters: In vivo and in vitro studies |
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