A Rare Case of a Testicular Teratoma Associated with a Neuroendocrine Tumour
We report a rare case of testicular teratoma combined with a neuroendocrine tumour, emphasizing the difficulty of the following aspects: the clinical and laboratory diagnosis, the treatment options and the evolution of patients suffering from this disease. Case presentation: The patients with testic...
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Veröffentlicht in: | Chirurgia (Bucharest, Romania : 1990) Romania : 1990), 2019-03, Vol.114 (2), p.300-306 |
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creator | Prunoiu, Virgiliu Mihail Marincaş, Augustin Marian Alexandru, Aurelia Radu, Mădălina Proca, Tudor Marian Răvaş, Maria Manuela Brătucu, Eugen Ionescu, Sinziana |
description | We report a rare case of testicular teratoma combined with a neuroendocrine tumour, emphasizing the difficulty of the following aspects: the clinical and laboratory diagnosis, the treatment options and the evolution of patients suffering from this disease. Case presentation: The patients with testicular neuroendocrine tumours represent a rarity, considering that as of 2017, only 22 cases had been reported in the literature. The case operated on in our clinic presents an association between a testicular teratoma and a neuroendocrine tumour. A 39-year-old patient was admitted in our Department for a non-painful abdominal tumour and concomitant testicular tumour. The serum tumour markers (-human chorionic gonadotropin, -phetoprotein and lactate dehydrogenase) were within normal limits. Lung and bone metastases were diagnosed CT scan. The histopathological diagnosis consisted of immunohistochemical study of the orchidectomy specimen as well as of the bioptic material from bone marrow puncture.
The diagnosis of testicular carcinoids is based on immunohistochemistry study. Radical orchidectomy is the only potentially curative treatment for this type of malignancy. Adjuvant chemotherapy determined size reduction of the lung and bone metastases and the disappearance of the lymph node metastases. |
doi_str_mv | 10.21614/chirurgia.114.2.300 |
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The diagnosis of testicular carcinoids is based on immunohistochemistry study. Radical orchidectomy is the only potentially curative treatment for this type of malignancy. Adjuvant chemotherapy determined size reduction of the lung and bone metastases and the disappearance of the lymph node metastases.</description><identifier>ISSN: 1221-9118</identifier><identifier>DOI: 10.21614/chirurgia.114.2.300</identifier><identifier>PMID: 31060665</identifier><language>eng</language><publisher>Romania</publisher><subject>Adult ; Antineoplastic Agents - administration & dosage ; Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - secondary ; Bone Neoplasms - therapy ; Chemotherapy, Adjuvant ; Humans ; Immunohistochemistry ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - secondary ; Lung Neoplasms - therapy ; Lymphatic Metastasis ; Male ; Neuroendocrine Tumors - diagnostic imaging ; Neuroendocrine Tumors - secondary ; Neuroendocrine Tumors - therapy ; Orchiectomy ; Radiotherapy ; Retroperitoneal Neoplasms - diagnostic imaging ; Retroperitoneal Neoplasms - secondary ; Retroperitoneal Neoplasms - therapy ; Teratoma - diagnostic imaging ; Teratoma - secondary ; Teratoma - therapy ; Testicular Neoplasms - diagnostic imaging ; Testicular Neoplasms - pathology ; Testicular Neoplasms - therapy ; Treatment Outcome</subject><ispartof>Chirurgia (Bucharest, Romania : 1990), 2019-03, Vol.114 (2), p.300-306</ispartof><rights>Celsius.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c283t-18a30077d8fa07017cba86e51f21d606321ed4fb21708afefa605205082fdaa53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31060665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prunoiu, Virgiliu Mihail</creatorcontrib><creatorcontrib>Marincaş, Augustin Marian</creatorcontrib><creatorcontrib>Alexandru, Aurelia</creatorcontrib><creatorcontrib>Radu, Mădălina</creatorcontrib><creatorcontrib>Proca, Tudor Marian</creatorcontrib><creatorcontrib>Răvaş, Maria Manuela</creatorcontrib><creatorcontrib>Brătucu, Eugen</creatorcontrib><creatorcontrib>Ionescu, Sinziana</creatorcontrib><title>A Rare Case of a Testicular Teratoma Associated with a Neuroendocrine Tumour</title><title>Chirurgia (Bucharest, Romania : 1990)</title><addtitle>Chirurgia (Bucur)</addtitle><description>We report a rare case of testicular teratoma combined with a neuroendocrine tumour, emphasizing the difficulty of the following aspects: the clinical and laboratory diagnosis, the treatment options and the evolution of patients suffering from this disease. Case presentation: The patients with testicular neuroendocrine tumours represent a rarity, considering that as of 2017, only 22 cases had been reported in the literature. The case operated on in our clinic presents an association between a testicular teratoma and a neuroendocrine tumour. A 39-year-old patient was admitted in our Department for a non-painful abdominal tumour and concomitant testicular tumour. The serum tumour markers (-human chorionic gonadotropin, -phetoprotein and lactate dehydrogenase) were within normal limits. Lung and bone metastases were diagnosed CT scan. The histopathological diagnosis consisted of immunohistochemical study of the orchidectomy specimen as well as of the bioptic material from bone marrow puncture.
The diagnosis of testicular carcinoids is based on immunohistochemistry study. Radical orchidectomy is the only potentially curative treatment for this type of malignancy. Adjuvant chemotherapy determined size reduction of the lung and bone metastases and the disappearance of the lymph node metastases.</description><subject>Adult</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - secondary</subject><subject>Bone Neoplasms - therapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - secondary</subject><subject>Lung Neoplasms - therapy</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Neuroendocrine Tumors - diagnostic imaging</subject><subject>Neuroendocrine Tumors - secondary</subject><subject>Neuroendocrine Tumors - therapy</subject><subject>Orchiectomy</subject><subject>Radiotherapy</subject><subject>Retroperitoneal Neoplasms - diagnostic imaging</subject><subject>Retroperitoneal Neoplasms - secondary</subject><subject>Retroperitoneal Neoplasms - therapy</subject><subject>Teratoma - diagnostic imaging</subject><subject>Teratoma - secondary</subject><subject>Teratoma - therapy</subject><subject>Testicular Neoplasms - diagnostic imaging</subject><subject>Testicular Neoplasms - pathology</subject><subject>Testicular Neoplasms - therapy</subject><subject>Treatment Outcome</subject><issn>1221-9118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LAzEQxXNQbNH-ByI5etk1k-xHeizFLygKUs9hmk1sZLepyQbxvzfY2rnMHN578-MRcg2s5NBAdae3LqTw4bAEqEpeCsbOyBQ4h2IOICdkFuMny9Mwzpi4IBMB-W6aekpWC_qGwdAlRkO9pUjXJo5Opx5DPgOOfkC6iNFrh6Pp6Lcbt1n1YlLwZtd5HdzO0HUafApX5NxiH83suC_J-8P9evlUrF4fn5eLVaG5FGMBEjNi23bSImsZtHqDsjE1WA5d5hIcTFfZDYeWSbTGYsNqzmomue0Qa3FJbg-5--C_UuZVg4va9D3ujE9RcZ4jhJzXkKXVQaqDjzEYq_bBDRh-FDD1V5861adyfYqrzJZtN8cPaTOY7mT6L078Ap67bqc</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Prunoiu, Virgiliu Mihail</creator><creator>Marincaş, Augustin Marian</creator><creator>Alexandru, Aurelia</creator><creator>Radu, Mădălina</creator><creator>Proca, Tudor Marian</creator><creator>Răvaş, Maria Manuela</creator><creator>Brătucu, Eugen</creator><creator>Ionescu, Sinziana</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190301</creationdate><title>A Rare Case of a Testicular Teratoma Associated with a Neuroendocrine Tumour</title><author>Prunoiu, Virgiliu Mihail ; Marincaş, Augustin Marian ; Alexandru, Aurelia ; Radu, Mădălina ; Proca, Tudor Marian ; Răvaş, Maria Manuela ; Brătucu, Eugen ; Ionescu, Sinziana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c283t-18a30077d8fa07017cba86e51f21d606321ed4fb21708afefa605205082fdaa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - secondary</topic><topic>Bone Neoplasms - therapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - secondary</topic><topic>Lung Neoplasms - therapy</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Neuroendocrine Tumors - diagnostic imaging</topic><topic>Neuroendocrine Tumors - secondary</topic><topic>Neuroendocrine Tumors - therapy</topic><topic>Orchiectomy</topic><topic>Radiotherapy</topic><topic>Retroperitoneal Neoplasms - diagnostic imaging</topic><topic>Retroperitoneal Neoplasms - secondary</topic><topic>Retroperitoneal Neoplasms - therapy</topic><topic>Teratoma - diagnostic imaging</topic><topic>Teratoma - secondary</topic><topic>Teratoma - therapy</topic><topic>Testicular Neoplasms - diagnostic imaging</topic><topic>Testicular Neoplasms - pathology</topic><topic>Testicular Neoplasms - therapy</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Prunoiu, Virgiliu Mihail</creatorcontrib><creatorcontrib>Marincaş, Augustin Marian</creatorcontrib><creatorcontrib>Alexandru, Aurelia</creatorcontrib><creatorcontrib>Radu, Mădălina</creatorcontrib><creatorcontrib>Proca, Tudor Marian</creatorcontrib><creatorcontrib>Răvaş, Maria Manuela</creatorcontrib><creatorcontrib>Brătucu, Eugen</creatorcontrib><creatorcontrib>Ionescu, Sinziana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chirurgia (Bucharest, Romania : 1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prunoiu, Virgiliu Mihail</au><au>Marincaş, Augustin Marian</au><au>Alexandru, Aurelia</au><au>Radu, Mădălina</au><au>Proca, Tudor Marian</au><au>Răvaş, Maria Manuela</au><au>Brătucu, Eugen</au><au>Ionescu, Sinziana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Rare Case of a Testicular Teratoma Associated with a Neuroendocrine Tumour</atitle><jtitle>Chirurgia (Bucharest, Romania : 1990)</jtitle><addtitle>Chirurgia (Bucur)</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>114</volume><issue>2</issue><spage>300</spage><epage>306</epage><pages>300-306</pages><issn>1221-9118</issn><abstract>We report a rare case of testicular teratoma combined with a neuroendocrine tumour, emphasizing the difficulty of the following aspects: the clinical and laboratory diagnosis, the treatment options and the evolution of patients suffering from this disease. Case presentation: The patients with testicular neuroendocrine tumours represent a rarity, considering that as of 2017, only 22 cases had been reported in the literature. The case operated on in our clinic presents an association between a testicular teratoma and a neuroendocrine tumour. A 39-year-old patient was admitted in our Department for a non-painful abdominal tumour and concomitant testicular tumour. The serum tumour markers (-human chorionic gonadotropin, -phetoprotein and lactate dehydrogenase) were within normal limits. Lung and bone metastases were diagnosed CT scan. The histopathological diagnosis consisted of immunohistochemical study of the orchidectomy specimen as well as of the bioptic material from bone marrow puncture.
The diagnosis of testicular carcinoids is based on immunohistochemistry study. Radical orchidectomy is the only potentially curative treatment for this type of malignancy. Adjuvant chemotherapy determined size reduction of the lung and bone metastases and the disappearance of the lymph node metastases.</abstract><cop>Romania</cop><pmid>31060665</pmid><doi>10.21614/chirurgia.114.2.300</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Antineoplastic Agents - administration & dosage Bone Neoplasms - diagnostic imaging Bone Neoplasms - secondary Bone Neoplasms - therapy Chemotherapy, Adjuvant Humans Immunohistochemistry Lung Neoplasms - diagnostic imaging Lung Neoplasms - secondary Lung Neoplasms - therapy Lymphatic Metastasis Male Neuroendocrine Tumors - diagnostic imaging Neuroendocrine Tumors - secondary Neuroendocrine Tumors - therapy Orchiectomy Radiotherapy Retroperitoneal Neoplasms - diagnostic imaging Retroperitoneal Neoplasms - secondary Retroperitoneal Neoplasms - therapy Teratoma - diagnostic imaging Teratoma - secondary Teratoma - therapy Testicular Neoplasms - diagnostic imaging Testicular Neoplasms - pathology Testicular Neoplasms - therapy Treatment Outcome |
title | A Rare Case of a Testicular Teratoma Associated with a Neuroendocrine Tumour |
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