Regional Variations in Quality of Survival Among Men with Prostate Cancer Across the United Kingdom
Prostate cancer incidence, treatment, and survival rates vary throughout the UK, but little is known about regional differences in quality of survival. To investigate variations in patient-reported outcomes between UK countries and English Cancer Alliances. A cross-sectional postal survey of prostat...
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| Veröffentlicht in: | European urology 2019-08, Vol.76 (2), p.228-237 |
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| creator | Donnelly, David W. Gavin, Anna Downing, Amy Hounsome, Luke Kearney, Therese McNair, Emma Allan, Dawn Huws, Dyfed W. Wright, Penny Selby, Peter J. Kind, Paul Watson, Eila Wagland, Richard Wilding, Sarah Butcher, Hugh Mottram, Rebecca Allen, Majorie McSorley, Oonagh Sharp, Linda Mason, Malcolm D. Cross, William R. Catto, James W.F. Glaser, Adam W. |
| description | Prostate cancer incidence, treatment, and survival rates vary throughout the UK, but little is known about regional differences in quality of survival.
To investigate variations in patient-reported outcomes between UK countries and English Cancer Alliances.
A cross-sectional postal survey of prostate cancer survivors diagnosed 18–42mo previously.
Urinary, bowel, and sexual problems and vitality were patient reported using the Expanded Prostate Cancer Index Composite (EPIC-26) questionnaire. General health was also self-assessed. Regional variations were identified using multivariable log-linear regression.
A total of 35823 men responded, 60.8% of those invited. Self-assessed health was significantly lower than the UK average in Wales and Scotland. Respondents reported more urinary incontinence in Scotland, more urinary irritation/obstruction in Scotland and Northern Ireland (NI), poorer bowel function in Scotland and NI, worse sexual function in Scotland, and reduced vitality/hormonal function in Scotland, Wales, and NI. Self-assessed health was poorer than the English average in South Yorkshire and North-East and Cumbria, with more urinary incontinence in North-East and Cumbria and Peninsula, greater sexual problems in West Midlands, and poorer vitality in North-East and Cumbria and West Midlands. Limitations include difficulty identifying clinically significant differences and limited information on pretreatment conditions.
Despite adjustment for treatment, and clinical and sociodemographic factors, quality of survival among prostate cancer survivors varied by area of residence. Adoption of best practice from areas performing well could support enhanced survival quality in poorer performing areas, particularly with regard to bowel problems and vitality, where clinically relevant differences were reported.
We conducted a UK-wide survey of patient's quality of life after treatment for prostate cancer. Outcomes were found to vary depending upon where patients live. Different service providers need to ensure that all prostate cancer patients receive the same follow-up care.
Prostate cancer survivors from England report better quality of survival than those from Scotland, Wales, and Northern Ireland, with differences unrelated to treatment type, and patient and disease characteristics. Within England, regional variations in general health and functional outcome also exist. |
| doi_str_mv | 10.1016/j.eururo.2019.04.018 |
| format | Article |
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To investigate variations in patient-reported outcomes between UK countries and English Cancer Alliances.
A cross-sectional postal survey of prostate cancer survivors diagnosed 18–42mo previously.
Urinary, bowel, and sexual problems and vitality were patient reported using the Expanded Prostate Cancer Index Composite (EPIC-26) questionnaire. General health was also self-assessed. Regional variations were identified using multivariable log-linear regression.
A total of 35823 men responded, 60.8% of those invited. Self-assessed health was significantly lower than the UK average in Wales and Scotland. Respondents reported more urinary incontinence in Scotland, more urinary irritation/obstruction in Scotland and Northern Ireland (NI), poorer bowel function in Scotland and NI, worse sexual function in Scotland, and reduced vitality/hormonal function in Scotland, Wales, and NI. Self-assessed health was poorer than the English average in South Yorkshire and North-East and Cumbria, with more urinary incontinence in North-East and Cumbria and Peninsula, greater sexual problems in West Midlands, and poorer vitality in North-East and Cumbria and West Midlands. Limitations include difficulty identifying clinically significant differences and limited information on pretreatment conditions.
Despite adjustment for treatment, and clinical and sociodemographic factors, quality of survival among prostate cancer survivors varied by area of residence. Adoption of best practice from areas performing well could support enhanced survival quality in poorer performing areas, particularly with regard to bowel problems and vitality, where clinically relevant differences were reported.
We conducted a UK-wide survey of patient's quality of life after treatment for prostate cancer. Outcomes were found to vary depending upon where patients live. Different service providers need to ensure that all prostate cancer patients receive the same follow-up care.
Prostate cancer survivors from England report better quality of survival than those from Scotland, Wales, and Northern Ireland, with differences unrelated to treatment type, and patient and disease characteristics. Within England, regional variations in general health and functional outcome also exist.</description><identifier>ISSN: 0302-2838</identifier><identifier>EISSN: 1873-7560</identifier><identifier>DOI: 10.1016/j.eururo.2019.04.018</identifier><identifier>PMID: 31060822</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>Cancer Alliances ; Patient-reported outcomes ; Prostate cancer ; Quality of survival ; Regional variation ; Treatment</subject><ispartof>European urology, 2019-08, Vol.76 (2), p.228-237</ispartof><rights>2019 The Author(s)</rights><rights>Copyright © 2019 The Author(s). Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-a6e461118dff68b90be56aabc505fa34a7a5e6b19d33606b4461725436db68783</citedby><cites>FETCH-LOGICAL-c408t-a6e461118dff68b90be56aabc505fa34a7a5e6b19d33606b4461725436db68783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030228381930329X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31060822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donnelly, David W.</creatorcontrib><creatorcontrib>Gavin, Anna</creatorcontrib><creatorcontrib>Downing, Amy</creatorcontrib><creatorcontrib>Hounsome, Luke</creatorcontrib><creatorcontrib>Kearney, Therese</creatorcontrib><creatorcontrib>McNair, Emma</creatorcontrib><creatorcontrib>Allan, Dawn</creatorcontrib><creatorcontrib>Huws, Dyfed W.</creatorcontrib><creatorcontrib>Wright, Penny</creatorcontrib><creatorcontrib>Selby, Peter J.</creatorcontrib><creatorcontrib>Kind, Paul</creatorcontrib><creatorcontrib>Watson, Eila</creatorcontrib><creatorcontrib>Wagland, Richard</creatorcontrib><creatorcontrib>Wilding, Sarah</creatorcontrib><creatorcontrib>Butcher, Hugh</creatorcontrib><creatorcontrib>Mottram, Rebecca</creatorcontrib><creatorcontrib>Allen, Majorie</creatorcontrib><creatorcontrib>McSorley, Oonagh</creatorcontrib><creatorcontrib>Sharp, Linda</creatorcontrib><creatorcontrib>Mason, Malcolm D.</creatorcontrib><creatorcontrib>Cross, William R.</creatorcontrib><creatorcontrib>Catto, James W.F.</creatorcontrib><creatorcontrib>Glaser, Adam W.</creatorcontrib><title>Regional Variations in Quality of Survival Among Men with Prostate Cancer Across the United Kingdom</title><title>European urology</title><addtitle>Eur Urol</addtitle><description>Prostate cancer incidence, treatment, and survival rates vary throughout the UK, but little is known about regional differences in quality of survival.
To investigate variations in patient-reported outcomes between UK countries and English Cancer Alliances.
A cross-sectional postal survey of prostate cancer survivors diagnosed 18–42mo previously.
Urinary, bowel, and sexual problems and vitality were patient reported using the Expanded Prostate Cancer Index Composite (EPIC-26) questionnaire. General health was also self-assessed. Regional variations were identified using multivariable log-linear regression.
A total of 35823 men responded, 60.8% of those invited. Self-assessed health was significantly lower than the UK average in Wales and Scotland. Respondents reported more urinary incontinence in Scotland, more urinary irritation/obstruction in Scotland and Northern Ireland (NI), poorer bowel function in Scotland and NI, worse sexual function in Scotland, and reduced vitality/hormonal function in Scotland, Wales, and NI. Self-assessed health was poorer than the English average in South Yorkshire and North-East and Cumbria, with more urinary incontinence in North-East and Cumbria and Peninsula, greater sexual problems in West Midlands, and poorer vitality in North-East and Cumbria and West Midlands. Limitations include difficulty identifying clinically significant differences and limited information on pretreatment conditions.
Despite adjustment for treatment, and clinical and sociodemographic factors, quality of survival among prostate cancer survivors varied by area of residence. Adoption of best practice from areas performing well could support enhanced survival quality in poorer performing areas, particularly with regard to bowel problems and vitality, where clinically relevant differences were reported.
We conducted a UK-wide survey of patient's quality of life after treatment for prostate cancer. Outcomes were found to vary depending upon where patients live. Different service providers need to ensure that all prostate cancer patients receive the same follow-up care.
Prostate cancer survivors from England report better quality of survival than those from Scotland, Wales, and Northern Ireland, with differences unrelated to treatment type, and patient and disease characteristics. Within England, regional variations in general health and functional outcome also exist.</description><subject>Cancer Alliances</subject><subject>Patient-reported outcomes</subject><subject>Prostate cancer</subject><subject>Quality of survival</subject><subject>Regional variation</subject><subject>Treatment</subject><issn>0302-2838</issn><issn>1873-7560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kEtP3DAQgK2qqCyPf1BVPvaSMLYTx3uptFq1pSoIWh5Xy0kmi1dJDLazFf8eL7tw7GlGo29eHyGfGeQMmDxb5zj5ybucA5vnUOTA1AcyY6oSWVVK-EhmIIBnXAl1SI5CWAOAKOfiEzkUDCQozmek-Ysr60bT03vjrYkpD9SO9M9kehufqevozeQ3dpOIxeDGFb3Ekf6z8YFeexeiiUiXZmzQ00WTCoHGB6R3o43Y0t92XLVuOCEHnekDnu7jMbn78f12eZ5dXP38tVxcZE0BKmZGYiEZY6rtOqnqOdRYSmPqpoSyM6IwlSlR1mzeCiFB1kWiK14WQra1VJUSx-Trbu6jd08ThqgHGxrsezOim4LmXHAmFC8hocUOfb3ZY6cfvR2Mf9YM9FavXuudXr3Vq6HQSW9q-7LfMNUDtu9Nbz4T8G0HYPpzY9Hr0FhMelrrsYm6dfb_G14ASf-NjA</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Donnelly, David W.</creator><creator>Gavin, Anna</creator><creator>Downing, Amy</creator><creator>Hounsome, Luke</creator><creator>Kearney, Therese</creator><creator>McNair, Emma</creator><creator>Allan, Dawn</creator><creator>Huws, Dyfed W.</creator><creator>Wright, Penny</creator><creator>Selby, Peter J.</creator><creator>Kind, Paul</creator><creator>Watson, Eila</creator><creator>Wagland, Richard</creator><creator>Wilding, Sarah</creator><creator>Butcher, Hugh</creator><creator>Mottram, Rebecca</creator><creator>Allen, Majorie</creator><creator>McSorley, Oonagh</creator><creator>Sharp, Linda</creator><creator>Mason, Malcolm D.</creator><creator>Cross, William R.</creator><creator>Catto, James W.F.</creator><creator>Glaser, Adam W.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201908</creationdate><title>Regional Variations in Quality of Survival Among Men with Prostate Cancer Across the United Kingdom</title><author>Donnelly, David W. ; 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To investigate variations in patient-reported outcomes between UK countries and English Cancer Alliances.
A cross-sectional postal survey of prostate cancer survivors diagnosed 18–42mo previously.
Urinary, bowel, and sexual problems and vitality were patient reported using the Expanded Prostate Cancer Index Composite (EPIC-26) questionnaire. General health was also self-assessed. Regional variations were identified using multivariable log-linear regression.
A total of 35823 men responded, 60.8% of those invited. Self-assessed health was significantly lower than the UK average in Wales and Scotland. Respondents reported more urinary incontinence in Scotland, more urinary irritation/obstruction in Scotland and Northern Ireland (NI), poorer bowel function in Scotland and NI, worse sexual function in Scotland, and reduced vitality/hormonal function in Scotland, Wales, and NI. Self-assessed health was poorer than the English average in South Yorkshire and North-East and Cumbria, with more urinary incontinence in North-East and Cumbria and Peninsula, greater sexual problems in West Midlands, and poorer vitality in North-East and Cumbria and West Midlands. Limitations include difficulty identifying clinically significant differences and limited information on pretreatment conditions.
Despite adjustment for treatment, and clinical and sociodemographic factors, quality of survival among prostate cancer survivors varied by area of residence. Adoption of best practice from areas performing well could support enhanced survival quality in poorer performing areas, particularly with regard to bowel problems and vitality, where clinically relevant differences were reported.
We conducted a UK-wide survey of patient's quality of life after treatment for prostate cancer. Outcomes were found to vary depending upon where patients live. Different service providers need to ensure that all prostate cancer patients receive the same follow-up care.
Prostate cancer survivors from England report better quality of survival than those from Scotland, Wales, and Northern Ireland, with differences unrelated to treatment type, and patient and disease characteristics. Within England, regional variations in general health and functional outcome also exist.</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>31060822</pmid><doi>10.1016/j.eururo.2019.04.018</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Cancer Alliances Patient-reported outcomes Prostate cancer Quality of survival Regional variation Treatment |
| title | Regional Variations in Quality of Survival Among Men with Prostate Cancer Across the United Kingdom |
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