A I131V Substitution in the Fusion Glycoprotein of Human Parainfluenza Virus Type 1 Enhances Syncytium Formation and Virus Growth

Human parainfluenza virus type 1 (hPIV1) has two spike glycoproteins, the hemagglutinin-neuraminidase (HN) glycoprotein as a receptor-binding protein and the fusion (F) glycoprotein as a membrane-fusion protein. The F glycoprotein mediates both membrane fusion between the virus and cell and membrane...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2019/05/01, Vol.42(5), pp.827-832
Hauptverfasser:	Fukushima, Keijo, Takahashi, Tadanobu, Takaguchi, Masahiro, Ito, Seigo, Suzuki, Chihiro, Agarikuchi, Takashi, Kurebayashi, Yuuki, Minami, Akira, Suzuki, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid substitution Cell fusion cell-to-cell direct transmission Exo-a-sialidase fusion glycoprotein Fusion protein Glycoproteins Hemagglutinins human parainfluenza virus type 1 Membrane fusion Membrane proteins Parainfluenza Spike glycoprotein syncytium formation virus growth Viruses
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