The clinical spectrum of reversible cerebral vasoconstriction syndrome: The Italian Project on Stroke at Young Age (IPSYS)
Introduction To describe clinical, neuroimaging, and laboratory features of a large cohort of Italian patients with reversible cerebral vasoconstriction syndrome. Methods In the setting of the multicenter Italian Project on Stroke at Young Age (IPSYS), we retrospectively enrolled patients with a dia...
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| Veröffentlicht in: | Cephalalgia 2019-09, Vol.39 (10), p.1267-1276 |
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| creator | Caria, Filomena Zedde, Marialuisa Gamba, Massimo Bersano, Anna Rasura, Maurizia Adami, Alessandro Piantadosi, Carlo Quartuccio, Luca Azzini, Cristiano Melis, Maurizio Luisa Delodovici, Maria Dallocchio, Carlo Gandolfo, Carlo Cerrato, Paolo Motto, Cristina Melis, Fabio Chiti, Alberto Gentile, Mauro Bignamini, Valeria Morotti, Andrea Maria Lotti, Enrico Toriello, Antonella Costa, Paolo Silvestrelli, Giorgio Zini, Andrea De Giuli, Valeria Poli, Loris Paciaroni, Maurizio Lodigiani, Corrado Marcheselli, Simona Sanguigni, Sandro Del Sette, Massimo Monaco, Serena Lochner, Piergiorgio Zanferrari, Carla Anticoli, Sabrina Padovani, Alessandro Pezzini, Alessandro |
| description | Introduction
To describe clinical, neuroimaging, and laboratory features of a large cohort of Italian patients with reversible cerebral vasoconstriction syndrome.
Methods
In the setting of the multicenter Italian Project on Stroke at Young Age (IPSYS), we retrospectively enrolled patients with a diagnosis of definite reversible cerebral vasoconstriction syndrome according to the International Classification of Headache Disorders (ICHD)-3 beta criteria (6.7.3 Headache attributed to reversible cerebral vasoconstriction syndrome, imaging-proven). Clinical manifestations, neuroimaging, treatment, and clinical outcomes were evaluated in all patients. Characteristics of reversible cerebral vasoconstriction syndrome without typical causes (“idiopathic reversible cerebral vasoconstriction syndrome”) were compared with those of reversible cerebral vasoconstriction syndrome related to putative causative factors (“secondary reversible cerebral vasoconstriction syndrome”).
Results
A total of 102 patients (mean age, 47.2 ± 13.9 years; females, 85 [83.3%]) qualified for the analysis. Thunderclap headache at presentation was reported in 69 (67.6%) patients, and it typically recurred in 42 (60.9%). Compared to reversible cerebral vasoconstriction syndrome cases related to putative etiologic conditions (n = 21 [20.6%]), patients with idiopathic reversible cerebral vasoconstriction syndrome (n = 81 [79.4%]) were significantly older (49.2 ± 13.9 vs. 39.5 ± 11.4 years), had more frequently typical thunderclap headache (77.8% vs. 28.6%) and less frequently neurological complications (epileptic seizures, 11.1% vs. 38.1%; cerebral infarction, 6.1% vs. 33.3%), as well as concomitant reversible brain edema (25.9% vs. 47.6%).
Conclusions
Clinical manifestations and putative etiologies of reversible cerebral vasoconstriction syndrome in our series are slightly different from those observed in previous cohorts. This variability might be partly related to the coexistence of precipitating conditions with a putative etiologic role on disease occurrence. |
| doi_str_mv | 10.1177/0333102419849013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_AFRWT</sourceid><recordid>TN_cdi_proquest_miscellaneous_2232136131</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0333102419849013</sage_id><sourcerecordid>2232136131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-42b399318c56a607aa53f5afc25b8ac8f6932d6ac660fd8034189ffc5267fa3c3</originalsourceid><addsrcrecordid>eNp1kDtPwzAUhS0EoqWwMyGPZQj4kbgOW1XxqFSJSi1Dp8hx7OKSxMVOKpVfj6MWBiSmO5zvfNI9AFxjdIfxaHSPKKUYkRinPE4Rpiegj2PGI5Jycgr6XRx1eQ9ceL9BCCUMsXPQCyWGKON98LV8V1CWpjZSlNBvlWxcW0GroVM75bzJy5Arp3IX8p3wVtraN87Ixtga-n1dOFupB9h5po0ojajh3NlNEMEALBpnPxQUDVzZtl7D8VrB4XS-WC1uL8GZFqVXV8c7AG9Pj8vJSzR7fZ5OxrNIxog2UUxymqYUc5kwwdBIiITqRGhJkpwLyTVLKSmYkIwhXXBEY8xTrWVC2EgLKukADA_erbOfrfJNVhkvVVmKWtnWZ4RQginDFAcUHVDprPdO6WzrTCXcPsMo6xbP_i4eKjdHe5tXqvgt_EwcgOgAeLFW2ca2rg7f_i_8BlN5iGs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2232136131</pqid></control><display><type>article</type><title>The clinical spectrum of reversible cerebral vasoconstriction syndrome: The Italian Project on Stroke at Young Age (IPSYS)</title><source>Sage Journals GOLD Open Access 2024</source><creator>Caria, Filomena ; Zedde, Marialuisa ; Gamba, Massimo ; Bersano, Anna ; Rasura, Maurizia ; Adami, Alessandro ; Piantadosi, Carlo ; Quartuccio, Luca ; Azzini, Cristiano ; Melis, Maurizio ; Luisa Delodovici, Maria ; Dallocchio, Carlo ; Gandolfo, Carlo ; Cerrato, Paolo ; Motto, Cristina ; Melis, Fabio ; Chiti, Alberto ; Gentile, Mauro ; Bignamini, Valeria ; Morotti, Andrea ; Maria Lotti, Enrico ; Toriello, Antonella ; Costa, Paolo ; Silvestrelli, Giorgio ; Zini, Andrea ; De Giuli, Valeria ; Poli, Loris ; Paciaroni, Maurizio ; Lodigiani, Corrado ; Marcheselli, Simona ; Sanguigni, Sandro ; Del Sette, Massimo ; Monaco, Serena ; Lochner, Piergiorgio ; Zanferrari, Carla ; Anticoli, Sabrina ; Padovani, Alessandro ; Pezzini, Alessandro</creator><creatorcontrib>Caria, Filomena ; Zedde, Marialuisa ; Gamba, Massimo ; Bersano, Anna ; Rasura, Maurizia ; Adami, Alessandro ; Piantadosi, Carlo ; Quartuccio, Luca ; Azzini, Cristiano ; Melis, Maurizio ; Luisa Delodovici, Maria ; Dallocchio, Carlo ; Gandolfo, Carlo ; Cerrato, Paolo ; Motto, Cristina ; Melis, Fabio ; Chiti, Alberto ; Gentile, Mauro ; Bignamini, Valeria ; Morotti, Andrea ; Maria Lotti, Enrico ; Toriello, Antonella ; Costa, Paolo ; Silvestrelli, Giorgio ; Zini, Andrea ; De Giuli, Valeria ; Poli, Loris ; Paciaroni, Maurizio ; Lodigiani, Corrado ; Marcheselli, Simona ; Sanguigni, Sandro ; Del Sette, Massimo ; Monaco, Serena ; Lochner, Piergiorgio ; Zanferrari, Carla ; Anticoli, Sabrina ; Padovani, Alessandro ; Pezzini, Alessandro ; Italian Project on Stroke at Young Age (IPSYS) Investigators ; on behalf of the Italian Project on Stroke at Young Age (IPSYS) Investigators</creatorcontrib><description>Introduction
To describe clinical, neuroimaging, and laboratory features of a large cohort of Italian patients with reversible cerebral vasoconstriction syndrome.
Methods
In the setting of the multicenter Italian Project on Stroke at Young Age (IPSYS), we retrospectively enrolled patients with a diagnosis of definite reversible cerebral vasoconstriction syndrome according to the International Classification of Headache Disorders (ICHD)-3 beta criteria (6.7.3 Headache attributed to reversible cerebral vasoconstriction syndrome, imaging-proven). Clinical manifestations, neuroimaging, treatment, and clinical outcomes were evaluated in all patients. Characteristics of reversible cerebral vasoconstriction syndrome without typical causes (“idiopathic reversible cerebral vasoconstriction syndrome”) were compared with those of reversible cerebral vasoconstriction syndrome related to putative causative factors (“secondary reversible cerebral vasoconstriction syndrome”).
Results
A total of 102 patients (mean age, 47.2 ± 13.9 years; females, 85 [83.3%]) qualified for the analysis. Thunderclap headache at presentation was reported in 69 (67.6%) patients, and it typically recurred in 42 (60.9%). Compared to reversible cerebral vasoconstriction syndrome cases related to putative etiologic conditions (n = 21 [20.6%]), patients with idiopathic reversible cerebral vasoconstriction syndrome (n = 81 [79.4%]) were significantly older (49.2 ± 13.9 vs. 39.5 ± 11.4 years), had more frequently typical thunderclap headache (77.8% vs. 28.6%) and less frequently neurological complications (epileptic seizures, 11.1% vs. 38.1%; cerebral infarction, 6.1% vs. 33.3%), as well as concomitant reversible brain edema (25.9% vs. 47.6%).
Conclusions
Clinical manifestations and putative etiologies of reversible cerebral vasoconstriction syndrome in our series are slightly different from those observed in previous cohorts. This variability might be partly related to the coexistence of precipitating conditions with a putative etiologic role on disease occurrence.</description><identifier>ISSN: 0333-1024</identifier><identifier>EISSN: 1468-2982</identifier><identifier>DOI: 10.1177/0333102419849013</identifier><identifier>PMID: 31060368</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><ispartof>Cephalalgia, 2019-09, Vol.39 (10), p.1267-1276</ispartof><rights>International Headache Society 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-42b399318c56a607aa53f5afc25b8ac8f6932d6ac660fd8034189ffc5267fa3c3</citedby><cites>FETCH-LOGICAL-c403t-42b399318c56a607aa53f5afc25b8ac8f6932d6ac660fd8034189ffc5267fa3c3</cites><orcidid>0000-0001-8629-3315</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0333102419849013$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0333102419849013$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0333102419849013?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31060368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caria, Filomena</creatorcontrib><creatorcontrib>Zedde, Marialuisa</creatorcontrib><creatorcontrib>Gamba, Massimo</creatorcontrib><creatorcontrib>Bersano, Anna</creatorcontrib><creatorcontrib>Rasura, Maurizia</creatorcontrib><creatorcontrib>Adami, Alessandro</creatorcontrib><creatorcontrib>Piantadosi, Carlo</creatorcontrib><creatorcontrib>Quartuccio, Luca</creatorcontrib><creatorcontrib>Azzini, Cristiano</creatorcontrib><creatorcontrib>Melis, Maurizio</creatorcontrib><creatorcontrib>Luisa Delodovici, Maria</creatorcontrib><creatorcontrib>Dallocchio, Carlo</creatorcontrib><creatorcontrib>Gandolfo, Carlo</creatorcontrib><creatorcontrib>Cerrato, Paolo</creatorcontrib><creatorcontrib>Motto, Cristina</creatorcontrib><creatorcontrib>Melis, Fabio</creatorcontrib><creatorcontrib>Chiti, Alberto</creatorcontrib><creatorcontrib>Gentile, Mauro</creatorcontrib><creatorcontrib>Bignamini, Valeria</creatorcontrib><creatorcontrib>Morotti, Andrea</creatorcontrib><creatorcontrib>Maria Lotti, Enrico</creatorcontrib><creatorcontrib>Toriello, Antonella</creatorcontrib><creatorcontrib>Costa, Paolo</creatorcontrib><creatorcontrib>Silvestrelli, Giorgio</creatorcontrib><creatorcontrib>Zini, Andrea</creatorcontrib><creatorcontrib>De Giuli, Valeria</creatorcontrib><creatorcontrib>Poli, Loris</creatorcontrib><creatorcontrib>Paciaroni, Maurizio</creatorcontrib><creatorcontrib>Lodigiani, Corrado</creatorcontrib><creatorcontrib>Marcheselli, Simona</creatorcontrib><creatorcontrib>Sanguigni, Sandro</creatorcontrib><creatorcontrib>Del Sette, Massimo</creatorcontrib><creatorcontrib>Monaco, Serena</creatorcontrib><creatorcontrib>Lochner, Piergiorgio</creatorcontrib><creatorcontrib>Zanferrari, Carla</creatorcontrib><creatorcontrib>Anticoli, Sabrina</creatorcontrib><creatorcontrib>Padovani, Alessandro</creatorcontrib><creatorcontrib>Pezzini, Alessandro</creatorcontrib><creatorcontrib>Italian Project on Stroke at Young Age (IPSYS) Investigators</creatorcontrib><creatorcontrib>on behalf of the Italian Project on Stroke at Young Age (IPSYS) Investigators</creatorcontrib><title>The clinical spectrum of reversible cerebral vasoconstriction syndrome: The Italian Project on Stroke at Young Age (IPSYS)</title><title>Cephalalgia</title><addtitle>Cephalalgia</addtitle><description>Introduction
To describe clinical, neuroimaging, and laboratory features of a large cohort of Italian patients with reversible cerebral vasoconstriction syndrome.
Methods
In the setting of the multicenter Italian Project on Stroke at Young Age (IPSYS), we retrospectively enrolled patients with a diagnosis of definite reversible cerebral vasoconstriction syndrome according to the International Classification of Headache Disorders (ICHD)-3 beta criteria (6.7.3 Headache attributed to reversible cerebral vasoconstriction syndrome, imaging-proven). Clinical manifestations, neuroimaging, treatment, and clinical outcomes were evaluated in all patients. Characteristics of reversible cerebral vasoconstriction syndrome without typical causes (“idiopathic reversible cerebral vasoconstriction syndrome”) were compared with those of reversible cerebral vasoconstriction syndrome related to putative causative factors (“secondary reversible cerebral vasoconstriction syndrome”).
Results
A total of 102 patients (mean age, 47.2 ± 13.9 years; females, 85 [83.3%]) qualified for the analysis. Thunderclap headache at presentation was reported in 69 (67.6%) patients, and it typically recurred in 42 (60.9%). Compared to reversible cerebral vasoconstriction syndrome cases related to putative etiologic conditions (n = 21 [20.6%]), patients with idiopathic reversible cerebral vasoconstriction syndrome (n = 81 [79.4%]) were significantly older (49.2 ± 13.9 vs. 39.5 ± 11.4 years), had more frequently typical thunderclap headache (77.8% vs. 28.6%) and less frequently neurological complications (epileptic seizures, 11.1% vs. 38.1%; cerebral infarction, 6.1% vs. 33.3%), as well as concomitant reversible brain edema (25.9% vs. 47.6%).
Conclusions
Clinical manifestations and putative etiologies of reversible cerebral vasoconstriction syndrome in our series are slightly different from those observed in previous cohorts. This variability might be partly related to the coexistence of precipitating conditions with a putative etiologic role on disease occurrence.</description><issn>0333-1024</issn><issn>1468-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kDtPwzAUhS0EoqWwMyGPZQj4kbgOW1XxqFSJSi1Dp8hx7OKSxMVOKpVfj6MWBiSmO5zvfNI9AFxjdIfxaHSPKKUYkRinPE4Rpiegj2PGI5Jycgr6XRx1eQ9ceL9BCCUMsXPQCyWGKON98LV8V1CWpjZSlNBvlWxcW0GroVM75bzJy5Arp3IX8p3wVtraN87Ixtga-n1dOFupB9h5po0ojajh3NlNEMEALBpnPxQUDVzZtl7D8VrB4XS-WC1uL8GZFqVXV8c7AG9Pj8vJSzR7fZ5OxrNIxog2UUxymqYUc5kwwdBIiITqRGhJkpwLyTVLKSmYkIwhXXBEY8xTrWVC2EgLKukADA_erbOfrfJNVhkvVVmKWtnWZ4RQginDFAcUHVDprPdO6WzrTCXcPsMo6xbP_i4eKjdHe5tXqvgt_EwcgOgAeLFW2ca2rg7f_i_8BlN5iGs</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Caria, Filomena</creator><creator>Zedde, Marialuisa</creator><creator>Gamba, Massimo</creator><creator>Bersano, Anna</creator><creator>Rasura, Maurizia</creator><creator>Adami, Alessandro</creator><creator>Piantadosi, Carlo</creator><creator>Quartuccio, Luca</creator><creator>Azzini, Cristiano</creator><creator>Melis, Maurizio</creator><creator>Luisa Delodovici, Maria</creator><creator>Dallocchio, Carlo</creator><creator>Gandolfo, Carlo</creator><creator>Cerrato, Paolo</creator><creator>Motto, Cristina</creator><creator>Melis, Fabio</creator><creator>Chiti, Alberto</creator><creator>Gentile, Mauro</creator><creator>Bignamini, Valeria</creator><creator>Morotti, Andrea</creator><creator>Maria Lotti, Enrico</creator><creator>Toriello, Antonella</creator><creator>Costa, Paolo</creator><creator>Silvestrelli, Giorgio</creator><creator>Zini, Andrea</creator><creator>De Giuli, Valeria</creator><creator>Poli, Loris</creator><creator>Paciaroni, Maurizio</creator><creator>Lodigiani, Corrado</creator><creator>Marcheselli, Simona</creator><creator>Sanguigni, Sandro</creator><creator>Del Sette, Massimo</creator><creator>Monaco, Serena</creator><creator>Lochner, Piergiorgio</creator><creator>Zanferrari, Carla</creator><creator>Anticoli, Sabrina</creator><creator>Padovani, Alessandro</creator><creator>Pezzini, Alessandro</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8629-3315</orcidid></search><sort><creationdate>20190901</creationdate><title>The clinical spectrum of reversible cerebral vasoconstriction syndrome: The Italian Project on Stroke at Young Age (IPSYS)</title><author>Caria, Filomena ; Zedde, Marialuisa ; Gamba, Massimo ; Bersano, Anna ; Rasura, Maurizia ; Adami, Alessandro ; Piantadosi, Carlo ; Quartuccio, Luca ; Azzini, Cristiano ; Melis, Maurizio ; Luisa Delodovici, Maria ; Dallocchio, Carlo ; Gandolfo, Carlo ; Cerrato, Paolo ; Motto, Cristina ; Melis, Fabio ; Chiti, Alberto ; Gentile, Mauro ; Bignamini, Valeria ; Morotti, Andrea ; Maria Lotti, Enrico ; Toriello, Antonella ; Costa, Paolo ; Silvestrelli, Giorgio ; Zini, Andrea ; De Giuli, Valeria ; Poli, Loris ; Paciaroni, Maurizio ; Lodigiani, Corrado ; Marcheselli, Simona ; Sanguigni, Sandro ; Del Sette, Massimo ; Monaco, Serena ; Lochner, Piergiorgio ; Zanferrari, Carla ; Anticoli, Sabrina ; Padovani, Alessandro ; Pezzini, Alessandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-42b399318c56a607aa53f5afc25b8ac8f6932d6ac660fd8034189ffc5267fa3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caria, Filomena</creatorcontrib><creatorcontrib>Zedde, Marialuisa</creatorcontrib><creatorcontrib>Gamba, Massimo</creatorcontrib><creatorcontrib>Bersano, Anna</creatorcontrib><creatorcontrib>Rasura, Maurizia</creatorcontrib><creatorcontrib>Adami, Alessandro</creatorcontrib><creatorcontrib>Piantadosi, Carlo</creatorcontrib><creatorcontrib>Quartuccio, Luca</creatorcontrib><creatorcontrib>Azzini, Cristiano</creatorcontrib><creatorcontrib>Melis, Maurizio</creatorcontrib><creatorcontrib>Luisa Delodovici, Maria</creatorcontrib><creatorcontrib>Dallocchio, Carlo</creatorcontrib><creatorcontrib>Gandolfo, Carlo</creatorcontrib><creatorcontrib>Cerrato, Paolo</creatorcontrib><creatorcontrib>Motto, Cristina</creatorcontrib><creatorcontrib>Melis, Fabio</creatorcontrib><creatorcontrib>Chiti, Alberto</creatorcontrib><creatorcontrib>Gentile, Mauro</creatorcontrib><creatorcontrib>Bignamini, Valeria</creatorcontrib><creatorcontrib>Morotti, Andrea</creatorcontrib><creatorcontrib>Maria Lotti, Enrico</creatorcontrib><creatorcontrib>Toriello, Antonella</creatorcontrib><creatorcontrib>Costa, Paolo</creatorcontrib><creatorcontrib>Silvestrelli, Giorgio</creatorcontrib><creatorcontrib>Zini, Andrea</creatorcontrib><creatorcontrib>De Giuli, Valeria</creatorcontrib><creatorcontrib>Poli, Loris</creatorcontrib><creatorcontrib>Paciaroni, Maurizio</creatorcontrib><creatorcontrib>Lodigiani, Corrado</creatorcontrib><creatorcontrib>Marcheselli, Simona</creatorcontrib><creatorcontrib>Sanguigni, Sandro</creatorcontrib><creatorcontrib>Del Sette, Massimo</creatorcontrib><creatorcontrib>Monaco, Serena</creatorcontrib><creatorcontrib>Lochner, Piergiorgio</creatorcontrib><creatorcontrib>Zanferrari, Carla</creatorcontrib><creatorcontrib>Anticoli, Sabrina</creatorcontrib><creatorcontrib>Padovani, Alessandro</creatorcontrib><creatorcontrib>Pezzini, Alessandro</creatorcontrib><creatorcontrib>Italian Project on Stroke at Young Age (IPSYS) Investigators</creatorcontrib><creatorcontrib>on behalf of the Italian Project on Stroke at Young Age (IPSYS) Investigators</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cephalalgia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Caria, Filomena</au><au>Zedde, Marialuisa</au><au>Gamba, Massimo</au><au>Bersano, Anna</au><au>Rasura, Maurizia</au><au>Adami, Alessandro</au><au>Piantadosi, Carlo</au><au>Quartuccio, Luca</au><au>Azzini, Cristiano</au><au>Melis, Maurizio</au><au>Luisa Delodovici, Maria</au><au>Dallocchio, Carlo</au><au>Gandolfo, Carlo</au><au>Cerrato, Paolo</au><au>Motto, Cristina</au><au>Melis, Fabio</au><au>Chiti, Alberto</au><au>Gentile, Mauro</au><au>Bignamini, Valeria</au><au>Morotti, Andrea</au><au>Maria Lotti, Enrico</au><au>Toriello, Antonella</au><au>Costa, Paolo</au><au>Silvestrelli, Giorgio</au><au>Zini, Andrea</au><au>De Giuli, Valeria</au><au>Poli, Loris</au><au>Paciaroni, Maurizio</au><au>Lodigiani, Corrado</au><au>Marcheselli, Simona</au><au>Sanguigni, Sandro</au><au>Del Sette, Massimo</au><au>Monaco, Serena</au><au>Lochner, Piergiorgio</au><au>Zanferrari, Carla</au><au>Anticoli, Sabrina</au><au>Padovani, Alessandro</au><au>Pezzini, Alessandro</au><aucorp>Italian Project on Stroke at Young Age (IPSYS) Investigators</aucorp><aucorp>on behalf of the Italian Project on Stroke at Young Age (IPSYS) Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical spectrum of reversible cerebral vasoconstriction syndrome: The Italian Project on Stroke at Young Age (IPSYS)</atitle><jtitle>Cephalalgia</jtitle><addtitle>Cephalalgia</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>39</volume><issue>10</issue><spage>1267</spage><epage>1276</epage><pages>1267-1276</pages><issn>0333-1024</issn><eissn>1468-2982</eissn><abstract>Introduction
To describe clinical, neuroimaging, and laboratory features of a large cohort of Italian patients with reversible cerebral vasoconstriction syndrome.
Methods
In the setting of the multicenter Italian Project on Stroke at Young Age (IPSYS), we retrospectively enrolled patients with a diagnosis of definite reversible cerebral vasoconstriction syndrome according to the International Classification of Headache Disorders (ICHD)-3 beta criteria (6.7.3 Headache attributed to reversible cerebral vasoconstriction syndrome, imaging-proven). Clinical manifestations, neuroimaging, treatment, and clinical outcomes were evaluated in all patients. Characteristics of reversible cerebral vasoconstriction syndrome without typical causes (“idiopathic reversible cerebral vasoconstriction syndrome”) were compared with those of reversible cerebral vasoconstriction syndrome related to putative causative factors (“secondary reversible cerebral vasoconstriction syndrome”).
Results
A total of 102 patients (mean age, 47.2 ± 13.9 years; females, 85 [83.3%]) qualified for the analysis. Thunderclap headache at presentation was reported in 69 (67.6%) patients, and it typically recurred in 42 (60.9%). Compared to reversible cerebral vasoconstriction syndrome cases related to putative etiologic conditions (n = 21 [20.6%]), patients with idiopathic reversible cerebral vasoconstriction syndrome (n = 81 [79.4%]) were significantly older (49.2 ± 13.9 vs. 39.5 ± 11.4 years), had more frequently typical thunderclap headache (77.8% vs. 28.6%) and less frequently neurological complications (epileptic seizures, 11.1% vs. 38.1%; cerebral infarction, 6.1% vs. 33.3%), as well as concomitant reversible brain edema (25.9% vs. 47.6%).
Conclusions
Clinical manifestations and putative etiologies of reversible cerebral vasoconstriction syndrome in our series are slightly different from those observed in previous cohorts. This variability might be partly related to the coexistence of precipitating conditions with a putative etiologic role on disease occurrence.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>31060368</pmid><doi>10.1177/0333102419849013</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8629-3315</orcidid></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 0333-1024 |
| ispartof | Cephalalgia, 2019-09, Vol.39 (10), p.1267-1276 |
| issn | 0333-1024 1468-2982 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2232136131 |
| source | Sage Journals GOLD Open Access 2024 |
| title | The clinical spectrum of reversible cerebral vasoconstriction syndrome: The Italian Project on Stroke at Young Age (IPSYS) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T21%3A53%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_AFRWT&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20clinical%20spectrum%20of%20reversible%20cerebral%20vasoconstriction%20syndrome:%20The%20Italian%20Project%20on%20Stroke%20at%20Young%20Age%20(IPSYS)&rft.jtitle=Cephalalgia&rft.au=Caria,%20Filomena&rft.aucorp=Italian%20Project%20on%20Stroke%20at%20Young%20Age%20(IPSYS)%20Investigators&rft.date=2019-09-01&rft.volume=39&rft.issue=10&rft.spage=1267&rft.epage=1276&rft.pages=1267-1276&rft.issn=0333-1024&rft.eissn=1468-2982&rft_id=info:doi/10.1177/0333102419849013&rft_dat=%3Cproquest_AFRWT%3E2232136131%3C/proquest_AFRWT%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2232136131&rft_id=info:pmid/31060368&rft_sage_id=10.1177_0333102419849013&rfr_iscdi=true |