Hindgut and Midgut Neuroendocrine Tumors - Therapeutic Approach
Neuroendocrine tumors of the gastro-entero-pancreatic system have a variety of components, clinical manifestations and prognostic indices according to their anatomical site. Therefore, their diagnostic and management strategies differ a great deal. Prognosis concerning NETs can be poor due to the de...
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| Veröffentlicht in: | Chirurgia (Bucharest, Romania : 1990) Romania : 1990), 2019-03, Vol.114 (2), p.243-250 |
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| container_title | Chirurgia (Bucharest, Romania : 1990) |
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| creator | Gavrilescu, Mihaela Mădălina Huţanu, Ionuţ Filip, Bogdan Anitei, Maria Gabriela Buna-Arvinte, Mihaela Muşină, Ana-Maria Panuta, Adrian Moraru, Vanda Radu, Iulian Scripcariu, Dragoş Viorel Scripcariu, Viorel |
| description | Neuroendocrine tumors of the gastro-entero-pancreatic system have a variety of components, clinical manifestations and prognostic indices according to their anatomical site. Therefore, their diagnostic and management strategies differ a great deal. Prognosis concerning NETs can be poor due to the degree of differentiation, early metastasizing and the high degree of invasiveness. Material and
For the present study, the patient files were evaluated and the parameters of interest were followed.
Over the course of 6 years there were 37 patients diagnosed with and treated for NETs, regardless of primary tumor site. There were 9 patients with NETs of the primite mid- and hindgut thusly: 5 cases with colorectal NETs and 4 cases of small bowel NETs. 6 patients benefited from radical surgical treatment, 2 cases with palliative procedures and only one patient with tumor biopsy. The tumors were evaluated according to the 2010 WHO classification based on the number of mitoses and the Ki67 proliferation index. Adjuvant treatment was adapted according to staging and histopathological parameters.
Despite recent progress in managing NETs, there are still many controversial aspects regarding the management of these cases, mainly about timing the right sequence of therapy. |
| doi_str_mv | 10.21614/chirurgia.114.2.243 |
| format | Article |
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For the present study, the patient files were evaluated and the parameters of interest were followed.
Over the course of 6 years there were 37 patients diagnosed with and treated for NETs, regardless of primary tumor site. There were 9 patients with NETs of the primite mid- and hindgut thusly: 5 cases with colorectal NETs and 4 cases of small bowel NETs. 6 patients benefited from radical surgical treatment, 2 cases with palliative procedures and only one patient with tumor biopsy. The tumors were evaluated according to the 2010 WHO classification based on the number of mitoses and the Ki67 proliferation index. Adjuvant treatment was adapted according to staging and histopathological parameters.
Despite recent progress in managing NETs, there are still many controversial aspects regarding the management of these cases, mainly about timing the right sequence of therapy.</description><identifier>ISSN: 1221-9118</identifier><identifier>DOI: 10.21614/chirurgia.114.2.243</identifier><identifier>PMID: 31060657</identifier><language>eng</language><publisher>Romania</publisher><subject>Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Breast Neoplasms - diagnosis ; Breast Neoplasms - therapy ; Chemotherapy, Adjuvant ; Digestive System Neoplasms - diagnosis ; Digestive System Neoplasms - drug therapy ; Digestive System Neoplasms - surgery ; Digestive System Neoplasms - therapy ; Disease Management ; Female ; Humans ; Male ; Middle Aged ; Neuroendocrine Tumors - diagnosis ; Neuroendocrine Tumors - drug therapy ; Neuroendocrine Tumors - surgery ; Neuroendocrine Tumors - therapy ; Prognosis ; Retroperitoneal Neoplasms - diagnosis ; Retroperitoneal Neoplasms - therapy ; Treatment Outcome ; Uterine Neoplasms - diagnosis ; Uterine Neoplasms - therapy</subject><ispartof>Chirurgia (Bucharest, Romania : 1990), 2019-03, Vol.114 (2), p.243-250</ispartof><rights>Celsius.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31060657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gavrilescu, Mihaela Mădălina</creatorcontrib><creatorcontrib>Huţanu, Ionuţ</creatorcontrib><creatorcontrib>Filip, Bogdan</creatorcontrib><creatorcontrib>Anitei, Maria Gabriela</creatorcontrib><creatorcontrib>Buna-Arvinte, Mihaela</creatorcontrib><creatorcontrib>Muşină, Ana-Maria</creatorcontrib><creatorcontrib>Panuta, Adrian</creatorcontrib><creatorcontrib>Moraru, Vanda</creatorcontrib><creatorcontrib>Radu, Iulian</creatorcontrib><creatorcontrib>Scripcariu, Dragoş Viorel</creatorcontrib><creatorcontrib>Scripcariu, Viorel</creatorcontrib><title>Hindgut and Midgut Neuroendocrine Tumors - Therapeutic Approach</title><title>Chirurgia (Bucharest, Romania : 1990)</title><addtitle>Chirurgia (Bucur)</addtitle><description>Neuroendocrine tumors of the gastro-entero-pancreatic system have a variety of components, clinical manifestations and prognostic indices according to their anatomical site. Therefore, their diagnostic and management strategies differ a great deal. Prognosis concerning NETs can be poor due to the degree of differentiation, early metastasizing and the high degree of invasiveness. Material and
For the present study, the patient files were evaluated and the parameters of interest were followed.
Over the course of 6 years there were 37 patients diagnosed with and treated for NETs, regardless of primary tumor site. There were 9 patients with NETs of the primite mid- and hindgut thusly: 5 cases with colorectal NETs and 4 cases of small bowel NETs. 6 patients benefited from radical surgical treatment, 2 cases with palliative procedures and only one patient with tumor biopsy. The tumors were evaluated according to the 2010 WHO classification based on the number of mitoses and the Ki67 proliferation index. Adjuvant treatment was adapted according to staging and histopathological parameters.
Despite recent progress in managing NETs, there are still many controversial aspects regarding the management of these cases, mainly about timing the right sequence of therapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - therapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Digestive System Neoplasms - diagnosis</subject><subject>Digestive System Neoplasms - drug therapy</subject><subject>Digestive System Neoplasms - surgery</subject><subject>Digestive System Neoplasms - therapy</subject><subject>Disease Management</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuroendocrine Tumors - diagnosis</subject><subject>Neuroendocrine Tumors - drug therapy</subject><subject>Neuroendocrine Tumors - surgery</subject><subject>Neuroendocrine Tumors - therapy</subject><subject>Prognosis</subject><subject>Retroperitoneal Neoplasms - diagnosis</subject><subject>Retroperitoneal Neoplasms - therapy</subject><subject>Treatment Outcome</subject><subject>Uterine Neoplasms - diagnosis</subject><subject>Uterine Neoplasms - therapy</subject><issn>1221-9118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPAzEQhF2ASBTyDxC6kuYOe_24XIWiCAhSgCbUls_2JUa5B_a54N9jJSHb7BQzO9oPoTuCCyCCsEe9dz76nVMFIayAAhi9QlMCQPKKkMUEzUP4xmkEBozpDZpQkrTg5RQ9rV1ndnHMVGeyd3eUHzb63nam1951NtvGtvchy7Pt3no12Dg6nS2HwfdK72_RdaMOwc7Pe4a-Xp63q3W--Xx9Wy03uQYKYw5GYaFwxZumAVVzXjFTLziUJcOiYoILrq0gzYKWBoBi3djaMCqqpsTcMExn6OF0N9X-RBtG2bqg7eGgOtvHIFMICE1P0WRlJ6v2fQjeNnLwrlX-VxIsj8TkhZhMxCTIRCzF7s8NsW6tuYT-WdE_2cRqOA</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Gavrilescu, Mihaela Mădălina</creator><creator>Huţanu, Ionuţ</creator><creator>Filip, Bogdan</creator><creator>Anitei, Maria Gabriela</creator><creator>Buna-Arvinte, Mihaela</creator><creator>Muşină, Ana-Maria</creator><creator>Panuta, Adrian</creator><creator>Moraru, Vanda</creator><creator>Radu, Iulian</creator><creator>Scripcariu, Dragoş Viorel</creator><creator>Scripcariu, Viorel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190301</creationdate><title>Hindgut and Midgut Neuroendocrine Tumors - Therapeutic Approach</title><author>Gavrilescu, Mihaela Mădălina ; 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Therefore, their diagnostic and management strategies differ a great deal. Prognosis concerning NETs can be poor due to the degree of differentiation, early metastasizing and the high degree of invasiveness. Material and
For the present study, the patient files were evaluated and the parameters of interest were followed.
Over the course of 6 years there were 37 patients diagnosed with and treated for NETs, regardless of primary tumor site. There were 9 patients with NETs of the primite mid- and hindgut thusly: 5 cases with colorectal NETs and 4 cases of small bowel NETs. 6 patients benefited from radical surgical treatment, 2 cases with palliative procedures and only one patient with tumor biopsy. The tumors were evaluated according to the 2010 WHO classification based on the number of mitoses and the Ki67 proliferation index. Adjuvant treatment was adapted according to staging and histopathological parameters.
Despite recent progress in managing NETs, there are still many controversial aspects regarding the management of these cases, mainly about timing the right sequence of therapy.</abstract><cop>Romania</cop><pmid>31060657</pmid><doi>10.21614/chirurgia.114.2.243</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Breast Neoplasms - diagnosis Breast Neoplasms - therapy Chemotherapy, Adjuvant Digestive System Neoplasms - diagnosis Digestive System Neoplasms - drug therapy Digestive System Neoplasms - surgery Digestive System Neoplasms - therapy Disease Management Female Humans Male Middle Aged Neuroendocrine Tumors - diagnosis Neuroendocrine Tumors - drug therapy Neuroendocrine Tumors - surgery Neuroendocrine Tumors - therapy Prognosis Retroperitoneal Neoplasms - diagnosis Retroperitoneal Neoplasms - therapy Treatment Outcome Uterine Neoplasms - diagnosis Uterine Neoplasms - therapy |
| title | Hindgut and Midgut Neuroendocrine Tumors - Therapeutic Approach |
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